AGO3

This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

Argonaute RISC catalytic component 3

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol, Cytoplasmic bodies

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (35930718 - 36072500)

Ensembl ID

ENSG00000126070  (ver. 103.38)

Orthologs

Mouse Ago3: ENSMUSG00000028842

UniProt

Q9H9G7

neXtProt

NX_Q9H9G7

Human splice variants
Mouse splice variants

Protein structure