H00001406-M02

Gagliardi G, Ben M'Barek K, Chaffiol A, Slembrouck-Brec A, Conart JB, Nanteau C, Rabesandratana O, Sahel JA, Duebel J, Orieux G, Reichman S, Goureau O
Stem cell reports 2018 Sep 11;11(3):665-680

Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

Felemban M, Dorgau B, Hunt NC, Hallam D, Zerti D, Bauer R, Ding Y, Collin J, Steel D, Krasnogor N, Al-Aama J, Lindsay S, Mellough C, Lako M
Acta biomaterialia 2018 Jul 1;74:207-221

Notch Suppression Collaborates with Ascl1 and Lin28 to Unleash a Regenerative Response in Fish Retina, But Not in Mice.

Elsaeidi F, Macpherson P, Mills EA, Jui J, Flannery JG, Goldman D
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 Feb 28;38(9):2246-2261

Generation of Photoreceptor Precursors from Mouse Embryonic Stem Cells.

Lu AQ, Barnstable CJ
Stem cell reviews and reports 2018 Apr;14(2):247-261

Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular.

Izuogu OG, Alhasan AA, Mellough C, Collin J, Gallon R, Hyslop J, Mastrorosa FK, Ehrmann I, Lako M, Elliott DJ, Santibanez-Koref M, Jackson MS
BMC genomics 2018 Apr 20;19(1):276

Production of Retinal Cells from Confluent Human iPS Cells.

Reichman S, Goureau O
Methods in molecular biology (Clifton, N.J.) 2016;1357:339-51

Characterization and pharmacologic targeting of EZH2, a fetal retinal protein and epigenetic regulator, in human retinoblastoma.

Khan M, Walters LL, Li Q, Thomas DG, Miller JM, Zhang Q, Sciallis AP, Liu Y, Dlouhy BJ, Fort PE, Archer SM, Demirci H, Dou Y, Rao RC
Laboratory investigation; a journal of technical methods and pathology 2015 Nov;95(11):1278-90

Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line.

Sluch VM, Davis CH, Ranganathan V, Kerr JM, Krick K, Martin R, Berlinicke CA, Marsh-Armstrong N, Diamond JS, Mao HQ, Zack DJ
Scientific reports 2015 Nov 13;5:16595

Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells.

Ohlemacher SK, Iglesias CL, Sridhar A, Gamm DM, Meyer JS
Current protocols in stem cell biology 2015 Feb 2;32:1H.8.1-1H.8.20

Differentiation of retinal ganglion cells and photoreceptor precursors from mouse induced pluripotent stem cells carrying an Atoh7/Math5 lineage reporter.

Xie BB, Zhang XM, Hashimoto T, Tien AH, Chen A, Ge J, Yang XJ
PloS one 2014;9(11):e112175

The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina.

Masuda T, Zhang X, Berlinicke C, Wan J, Yerrabelli A, Conner EA, Kjellstrom S, Bush R, Thorgeirsson SS, Swaroop A, Chen S, Zack DJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 Nov 12;34(46):15356-68

Transplantation of photoreceptors derived from human Muller glia restore rod function in the P23H rat.

Jayaram H, Jones MF, Eastlake K, Cottrill PB, Becker S, Wiseman J, Khaw PT, Limb GA
Stem cells translational medicine 2014 Mar;3(3):323-33

From confluent human iPS cells to self-forming neural retina and retinal pigmented epithelium.

Reichman S, Terray A, Slembrouck A, Nanteau C, Orieux G, Habeler W, Nandrot EF, Sahel JA, Monville C, Goureau O
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 10;111(23):8518-23

Mechanistically distinct mouse models for CRX-associated retinopathy.

Tran NM, Zhang A, Zhang X, Huecker JB, Hennig AK, Chen S
PLoS genetics 2014 Feb;10(2):e1004111

The expression of retinal cell markers in human retinal pigment epithelial cells and their augmentation by the synthetic retinoid fenretinide.

Carr AJ, Vugler AA, Yu L, Semo M, Coffey P, Moss SE, Greenwood J
Molecular vision 2011;17:1701-15

Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina.

Sakagami K, Gan L, Yang XJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009 May 27;29(21):6932-44

BEST1 expression in the retinal pigment epithelium is modulated by OTX family members.

Esumi N, Kachi S, Hackler L Jr, Masuda T, Yang Z, Campochiaro PA, Zack DJ
Human molecular genetics 2009 Jan 1;18(1):128-41

Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation.

Peng GH, Chen S
Human molecular genetics 2007 Oct 15;16(20):2433-52

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: CRX/CORD2 Antibody (4G11) [H00001406-M02] - Analysis of CRX expression in transfected 293T cell line by CRX monoclonal antibody (M02), clone 4G11.Lane 1: CRX transfected lysate(32 KDa).Lane 2: Non-transfected lysate.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Western Blot: CRX/CORD2 Antibody (4G11) [H00001406-M02] - CRX monoclonal antibody (M02), clone 4G11 Analysis of CRX expression in IMR-32.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: ELISA: CRX/CORD2 Antibody (4G11) [H00001406-M02] - Detection limit for recombinant GST tagged CRX is approximately 0.03ng/ml as a capture antibody.