BS6029

antibody from Bioworld Technology, Inc
Targeting: SMNDC1 SMNR, SPF30, TDRD16C
Provider product page for BS6029
Western blot
Immunohistochemistry

Antibody data

Product number
BS6029 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SMNDC1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human SMNDC1.
Description
SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SMNDC1 protein structure - BS6029 shown in red.