BS3533

antibody from Bioworld Technology, Inc

Targeting: GRIN2D EB11, GluN2D, NMDAR2D, NR2D

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS3533

Provider

Bioworld Technology, Inc

Product name

NMDAš÷4 (L693) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic peptide, corresponding to amino acids 661-710 of Human NMDAš÷4.

Description

Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to -7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate, whereas the NMDA receptors exhibit slow kinetsis of Ca2+ ions and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: š÷ 1, 2, 3, 4 and one šø subunit. The šø subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.