GTX110807

Losko M, Lichawska-Cieslar A, Kulecka M, Paziewska A, Rumienczyk I, Mikula M, Jura J
Biochimica et biophysica acta. Molecular cell research 2018 Jan;1865(1):186-195

MCPIP1 inhibits coxsackievirus B3 replication by targeting viral RNA and negatively regulates virus-induced inflammation.

Li M, Yan K, Wei L, Yang Y, Qian Q, Xu W
Medical microbiology and immunology 2018 Feb;207(1):27-38

Spheroid-cultured human umbilical cord-derived mesenchymal stem cells attenuate hepatic ischemia-reperfusion injury in rats.

Sun Y, Wang Y, Zhou L, Zou Y, Huang G, Gao G, Ting S, Lei X, Ding X
Scientific reports 2018 Feb 6;8(1):2518

Central role of myeloid MCPIP1 in protecting against LPS-induced inflammation and lung injury.

Li Y, Huang X, Huang S, He H, Lei T, Saaoud F, Yu XQ, Melnick A, Kumar A, Papasian CJ, Fan D, Fu M
Signal transduction and targeted therapy 2017;2:17066

Modulation of influenza A virus replication by microRNA-9 through targeting MCPIP1.

Dong C, Sun X, Guan Z, Zhang M, Duan M
Journal of medical virology 2017 Jan;89(1):41-48

Histone deacetylase inhibitor vorinostat (SAHA, MK0683) perturb miR-9-MCPIP1 axis to block IL-1β-induced IL-6 expression in human OA chondrocytes.

Makki MS, Haqqi TM
Connective tissue research 2017 Jan;58(1):64-75

MG132 Induces Expression of Monocyte Chemotactic Protein-Induced Protein 1 in Vascular Smooth Muscle Cells.

Tan X, Gao J, Shi Z, Tai S, Chan LL, Yang Y, Peng DQ, Liao DF, Jiang ZS, Chang YZ, Gui Y, Zheng XL
Journal of cellular physiology 2017 Jan;232(1):122-8

MCPIP1 contributes to clear cell renal cell carcinomas development.

Ligeza J, Marona P, Gach N, Lipert B, Miekus K, Wilk W, Jaszczynski J, Stelmach A, Loboda A, Dulak J, Branicki W, Rys J, Jura J
Angiogenesis 2017 Aug;20(3):325-340

MCPIP-1, Alias Regnase-1, Controls Epithelial Inflammation by Posttranscriptional Regulation of IL-8 Production.

Dobosz E, Wilamowski M, Lech M, Bugara B, Jura J, Potempa J, Koziel J
Journal of innate immunity 2016;8(6):564-578

MCPIP1 RNase Is Aberrantly Distributed in Psoriatic Epidermis and Rapidly Induced by IL-17A.

Ruiz-Romeu E, Ferran M, Giménez-Arnau A, Bugara B, Lipert B, Jura J, Florencia EF, Prens EP, Celada A, Pujol RM, Santamaria-Babí LF
The Journal of investigative dermatology 2016 Aug;136(8):1599-1607

MicroRNA-9 promotion of interleukin-6 expression by inhibiting monocyte chemoattractant protein-induced protein 1 expression in interleukin-1β-stimulated human chondrocytes.

Makki MS, Haseeb A, Haqqi TM
Arthritis & rheumatology (Hoboken, N.J.) 2015 May;67(8):2117-28

Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation.

Huang S, Liu S, Fu JJ, Tony Wang T, Yao X, Kumar A, Liu G, Fu M
The Journal of biological chemistry 2015 Aug 21;290(34):20782-92

MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB.

Skalniak L, Dziendziel M, Jura J
Molecular and cellular biochemistry 2014 Oct;395(1-2):253-63

MCPIP1 suppresses hepatitis C virus replication and negatively regulates virus-induced proinflammatory cytokine responses.

Lin RJ, Chu JS, Chien HL, Tseng CH, Ko PC, Mei YY, Tang WC, Kao YT, Cheng HY, Liang YC, Lin SY
Journal of immunology (Baltimore, Md. : 1950) 2014 Oct 15;193(8):4159-68

MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells.

Liu S, Qiu C, Miao R, Zhou J, Lee A, Liu B, Lester SN, Fu W, Zhu L, Zhang L, Xu J, Fan D, Li K, Fu M, Wang T
Proceedings of the National Academy of Sciences of the United States of America 2013 Nov 19;110(47):19083-8

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation.

Lin RJ, Chien HL, Lin SY, Chang BL, Yu HP, Tang WC, Lin YL
Nucleic acids research 2013 Mar 1;41(5):3314-26

Proteasome inhibitor MG-132 induces MCPIP1 expression.

Skalniak L, Koj A, Jura J
The FEBS journal 2013 Jun;280(11):2665-74

MCP-induced protein 1 suppresses TNFalpha-induced VCAM-1 expression in human endothelial cells.

Qi Y, Liang J, She ZG, Cai Y, Wang J, Lei T, Stallcup WB, Fu M
FEBS letters 2010 Jul 16;584(14):3065-72

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Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: ZC3H12A antibody [N3C3] detects ZC3H12A protein by western blot analysis.A. 30 ?g 293T whole cell extract B. 30 ?g A431 whole cell extract C. 30 ?g HeLa whole cell extract D. 30 ?g HepG2 whole cell extract7.5 % SDS-PAGEZC3H12A antibody [N3C3] (GTX110807) dilution: 1:1000
Validation comment: WB

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: ZC3H12A antibody detects ZC3H12A protein by western blot analysis. Various whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with ZC3H12A antibody (GTX110807) diluted at a dilution of 1:1000.
Validation comment: WB

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Various whole cell extracts (30 ?g) were separated by 7.5% SDS-PAGE, and the membrane was blotted with ZC3H12A antibody [N3C3] (GTX110807) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using ZC3H12A(GTX110807) antibody at 1:200 dilution.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: ZC3H12A antibody [N3C3] detects ZC3H12A protein at cytoplasm and nucleus in mouse kidney by immunohistochemical analysis. Sample: Paraffin-embedded mouse kidney. ZC3H12A antibody [N3C3] (GTX110807) diluted at 1:250.