DNAH6

This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Description

Dynein axonemal heavy chain 6

Tissue specificity

Tissue enhanced (brain, choroid plexus, fallopian tube)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

2 (84516455 - 84819589)

Ensembl ID

ENSG00000115423  (ver. 103.38)

Orthologs

Mouse Dnah6: ENSMUSG00000052861

UniProt

Q9C0G6

neXtProt

NX_Q9C0G6

Human splice variants
Mouse splice variants

Protein structure