CA11

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]

Description

Carbonic anhydrase 11

Tissue specificity

Group enriched (brain, choroid plexus)

Subcell location

Vesicles, Microtubules

Predicted location

Intracellular, Secreted in brain

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

19 (48637946 - 48646187)

Ensembl ID

ENSG00000063180  (ver. 103.38)

Orthologs

Mouse Car11: ENSMUSG00000003273

UniProt

O75493

neXtProt

NX_O75493

Human splice variants
Mouse splice variants

Protein structure