BS6001

antibody from Bioworld Technology, Inc
Targeting: CDCA8 BOR, DasraB, FLJ12042, MESRGP
Provider product page for BS6001
Western blot
Immunohistochemistry

Antibody data

Product number
BS6001 - Provider product page
Provider
Bioworld Technology, Inc
Product name
CDCA8 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human CDCA8.
Description
Borealin is a 280-amino acid protein that stabilizes the bipolar mitotic spindle. Borealin is part of a complex called Aurora B kinase that has essential regulatory roles at centromeres and the central spindle in cells undergoing mitosis. This complex makes up the enzymatic core of the chromosomal passenger complex (CPC). It is possible that the Borealin subunit directs the CPC to centromeric DNA. Deletion of Borealin delays mitotic progression and causes kinetochore-spindle to mis-attach. Deletion also causes an increase in bipolar spindles associated with ectopic asters. These extra poles, which form after chromosomes acquire their bipolar orientation, seriously disrupt chromosome allotment during anaphase.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
CDCA8 protein structure - BS6001 shown in red.