CABT-L1631

antibody from Creative Diagnostics
Targeting: TCF7L2 TCF-4, TCF4
Provider product page for CABT-L1631
Western blot
Immunoprecipitation
Chromatin Immunoprecipitation

Antibody data

Product number
CABT-L1631 - Provider product page
Provider
Creative Diagnostics
Product name
Rabbit Anti-Human TCF7L2 monoclonal antibody, clone F.009.3
Antibody type
Monoclonal
Description
TCF7L2, or TCF4, is a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. TCF7L2 has been implicated in glucose homeostasis through the regulation of pro-glucagon gene expression, which encodes glucagon-like peptide 1 (GLP-1). Genetic variants of TCF7L2 have been linked to type 2 diabetes, and it has specifically been shown to have an important role in the regulation of both beta-cell survival and function. Several splicing isoforms for TCF7L2 have been shown to be differentially expressed in tissues during cancer progression, and gene targeting studies indicate that TCF7L2 is required to maintain the crypt stem cells of the small intestine.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
F.009.3
Storage
-20°C
TCF7L2 protein structure - CABT-L1631 shown in red.