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Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Blocking/Neutralizing [1]
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- Product number
- MAB1159-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human PDGF-D Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human PDGF-D in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) PDGF, rhPDGF-AA, rhPDGF-AB, rhPDGF-BB, rhPDGF-C, or recombinant rat PDGF-AB is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
Q9GZP0.1- Isotype
- IgG
- Antibody clone number
- 680018
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Phenotypic plasticity in normal breast derived epithelial cells.
Sauder CA, Koziel JE, Choi M, Fox MJ, Grimes BR, Badve S, Blosser RJ, Radovich M, Lam CC, Vaughan MB, Herbert BS, Clare SE
BMC cell biology 2014 Jun 10;15:20
BMC cell biology 2014 Jun 10;15:20
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by PDGF-DD and Neutralization by Human PDGF-D Antibody. Recombinant Human PDGF-DD (Catalog # 1159-SB) stimulates proliferation in the NR6R-3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human PDGF-DD (0.75 ug/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human PDGF-D Monoclonal Antibody (Catalog # MAB1159). The ND50 is typically 1.5-7.5 µg/mL.
