21277-1-AP

antibody from Proteintech Group

Targeting: SCARB1 CD36L1, CLA-1, CLA1, SR-BI, SRB1

Provider product page for 21277-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [28]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 21277-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21277-1-AP, RRID:AB_10858921
Product name: SR-BI antibody
Antibody type: Polyclonal
Description: SR-BI antibody (Cat. #21277-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SCARB1 protein structure - 21277-1-AP shown in red.

Submitted references S-nitrosylation of HINT1 in macrophages aggravates foam cell formation and atherosclerosis.

Tang K, Zheng T, Zhu H, Xu F, Ma C, Qi Z, Cao S, Da Q, Yan K, Wu W, Han Y, Xie L, Zhang Y, Ji Y
Redox biology 2026 Mar;90:104063

Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway.

Zhang Z, Chen X, Hu X, Liang J, Huang H, Lu W, Zhu M, Fang M, Yin L, Li W, Zhang S
Journal of nanobiotechnology 2026 Feb 27;24(1)

Dual improvement effects of ω-3 on bone loss and liver injury in rats with liver-bone axis damage.

Huang J, Chen L, Yu H, Zhou S, Guan J, Xu C
Food & function 2026 Apr 14;17(7):3229-3247

Trps1 targets Scarb1 to regulate cholesterol acquisition in mouse Leydig cells.

Lian X, Lin Z, Hu W, Chen Z, Luo S, Liao S, Liu Y, Wang S, Sun J
Reproductive biology 2025 Sep;25(3):101046

MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype.

Xing L, Bu Y, Shi J, Liu J, Hu F, Zhang M, Fan J
Lipids in health and disease 2025 Oct 2;24(1):307

Syncytin-1 deficiency impairs placental nutrient transport via PI3K/Akt/mTOR signaling.

Chen XL, Gong XX, Xiong ZL, Zhou D, Yang J, Zhang HF, Xue YS, Wang YN, Chen HB
The Journal of nutritional biochemistry 2025 Dec;146:110060

α-GalCer regulates acute stress-induced steroidogenesis by modulating lipid metabolism in female BALB/c mice.

Gao Y, Liu P, Peng L, Li M, Ni B
Psychoneuroendocrinology 2025 Aug;178:107481

Age-Independent Hypocholesterolemic Effects of Rice Protein via FXR-Mediated Stimulation of Cholesterol Elimination.

Liu B, Wang Z, Liang M, Yang L
Food science & nutrition 2025 Aug;13(8):e70687

Inhibition of ferroptosis alleviates atherosclerosis and foam cell formation by regulating lipid metabolism via AMPK activation.

Yang Y, Chen Z, Song D, Wu J, Wang J, YouyouYan
International immunopharmacology 2025 Apr 24;153:114553

Flagellar hook protein FlgE promotes macrophage activation and atherosclerosis by targeting ATP5B.

Li Y, Zhang M, Li Y, Shen Y, Wang X, Li X, Wang Y, Yu T, Lv J, Qin Y
Atherosclerosis 2024 Mar;390:117429

Sirtuin 1-mediated autophagy regulates testosterone synthesis in Leydig cells of piglets.

Zhang Y, Yu L, He Y, Liu C, Abouelfetouh MM, Ju S, Zhou Z, Li Q
Theriogenology 2024 Dec;230:130-141

Dengue virus NS1 leads to downregulation of HNF4 alpha in liver cells resulting in a decrease in coagulation factors I, V, X, and XIII, contributing to coagulopathy.

Das S, Mallik MH, Chattopadyay P, Mallick S, Karmakar D, Ghora S, Begum F, Chatterjee B, Thagriki DS, Srivastava AK, Ray U
Journal of virology 2024 Dec 17;98(12):e0141824

Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.

Jin Q, Zhang C, Chen R, Jiang L, Li H, Wu P, Li L
Journal of translational medicine 2024 Apr 15;22(1):352

Inflammatory Cell-Derived MYDGF Attenuates Endothelial LDL Transcytosis to Protect Against Atherogenesis.

Xu J, Ma H, Shi L, Zhou H, Cheng Y, Tong J, Meng B, Xu X, He K, Ding S, Zhang J, Yue L, Xiang G
Arteriosclerosis, thrombosis, and vascular biology 2023 Nov;43(11):e443-e467

Resveratrol attenuates efavirenz-induced hepatic steatosis and hypercholesterolemia in mice by inhibiting pregnane X receptor activation and decreasing inflammation.

Miao X, Ye H, Cui X, Guo X, Su F
Nutrition research (New York, N.Y.) 2023 Nov;119:119-131

The NR_109/FUBP1/c-Myc axis regulates TAM polarization and remodels the tumor microenvironment to promote cancer development.

Zhang C, Wei S, Dai S, Li X, Wang H, Zhang H, Sun G, Shan B, Zhao L
Journal for immunotherapy of cancer 2023 May;11(5)

Engineered Microparticles for Treatment of Murine Brain Metastasis by Reprograming Tumor Microenvironment and Inhibiting MAPK Pathway.

Lu L, Zi H, Zhou J, Huang J, Deng Z, Tang Z, Li L, Shi X, Lo PC, Lovell JF, Deng D, Wan C, Jin H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Mar;10(8):e2206212

L-Theanine regulates lipid metabolism by modulating gut microbiota and bile acid metabolism.

Xu W, Kong Y, Zhang T, Gong Z, Xiao W
Journal of the science of food and agriculture 2023 Feb;103(3):1283-1293

Urolithin A protects severe acute pancreatitis-associated acute cardiac injury by regulating mitochondrial fatty acid oxidative metabolism in cardiomyocytes.

Yang Y, Hu Q, Kang H, Li J, Zhao X, Zhu L, Tang W, Wan M
MedComm 2023 Dec;4(6):e459

Inclisiran inhibits oxidized low-density lipoprotein-induced foam cell formation in Raw264.7 macrophages via activating the PPARγ pathway.

Wang Z, Chen X, Liu J, Wang Y, Zhang S
Autoimmunity 2022 Jun;55(4):223-232

Effects of Bushen Yiyuan recipe on testosterone synthesis in Leydig cells of rats with exercise-induced low serum testosterone levels.

Wang Y, Peng X, Zhou Z, Tang C, Liu W
Pharmaceutical biology 2022 Dec;60(1):1670-1678

Opuntia dillenii Haw. Polysaccharide Promotes Cholesterol Efflux in THP-1-Derived Foam Cells via the PPARγ-LXRα Signaling Pathway.

Li H, Huang Z, Zeng F
Molecules (Basel, Switzerland) 2022 Dec 7;27(24)

Photobiomodulation therapy promotes the ATP-binding cassette transporter A1-dependent cholesterol efflux in macrophage to ameliorate atherosclerosis.

Yin Q, Chang H, Shen Q, Xing D
Journal of cellular and molecular medicine 2021 Jun;25(11):5238-5249

Targeted immunomodulation of inflammatory monocytes across the blood-brain barrier by curcumin-loaded nanoparticles delays the progression of experimental autoimmune encephalomyelitis.

Lu L, Qi S, Chen Y, Luo H, Huang S, Yu X, Luo Q, Zhang Z
Biomaterials 2020 Jul;245:119987

Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction.

Li J, Xia K, Xiong M, Wang X, Yan N
Experimental and therapeutic medicine 2017 Dec;14(6):5635-5640

Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection.

Yang Z, Wang X, Chi X, Zhao F, Guo J, Ma P, Zhong J, Niu J, Pan X, Long G
Journal of virology 2016 Nov 1;90(21):9632-9643

TSH increases synthesis of hepatic ATP-binding cassette subfamily A member 1 in hypercholesterolemia.

Zhang T, Zhou L, Li CC, Shi H, Zhou X
Biochemical and biophysical research communications 2016 Jul 22;476(2):75-81

ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner.

Liu X, Ren K, Suo R, Xiong SL, Zhang QH, Mo ZC, Tang ZL, Jiang Y, Peng XS, Yi GH
Journal of physiology and biochemistry 2016 Dec;72(4):657-667

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 21277-1-AP(SCARB1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using SCARB1 antibody 21277-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line