BMP8B

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

Description

Bone morphogenetic protein 8b

Tissue specificity

Tissue enhanced (brain)

Subcell location

Vesicles

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

1 (39757182 - 39788865)

Ensembl ID

ENSG00000116985  (ver. 103.38)

Orthologs

-

UniProt

P34820

neXtProt

NX_P34820

Human splice variants

Protein structure