ALX-804-355-C100

antibody from Enzo Life Sciences

Targeting: CASP2 ICH1, MGC2181, NEDD2, PPP1R57

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

ALX-804-355-C100

Provider

Enzo Life Sciences

Proper citation

Enzo Life Sciences Cat#ALX-804-355-C100, RRID:AB_2050934

Product name

Caspase-2 monoclonal antibody (10C6)

Antibody type

Monoclonal

Antigen

Recombinant full length protein

Description

Protein G-affinity purified.

Reactivity

Human, Mouse, Rat, Canine, Simian

Host

Rat

Isotype

IgG

Antibody clone number

10C6

Vial size

100 μg

Storage

-20°C

Handling

Avoid freeze/thaw cycles.

References

Submitted references

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death.

Marsden VS, Kaufmann T, O'reilly LA, Adams JM, Strasser A
Blood 2006 Mar 1;107(5):1872-7

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Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation.

Scott CL, Schuler M, Marsden VS, Egle A, Pellegrini M, Nesic D, Gerondakis S, Nutt SL, Green DR, Strasser A
The Journal of cell biology 2004 Jan 5;164(1):89-96

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Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9.

O'Reilly LA, Ekert P, Harvey N, Marsden V, Cullen L, Vaux DL, Hacker G, Magnusson C, Pakusch M, Cecconi F, Kuida K, Strasser A, Huang DC, Kumar S
Cell death and differentiation 2002 Aug;9(8):832-41