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- Antibody Data
- Antigen structure
- References [85]
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- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
- Immunohistochemistry [2]
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- Product number
- 10179-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10179-1-AP, RRID:AB_2127193
- Product name
- Mitofilin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Mitofilin antibody (Cat. #10179-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Neurotransmitter accumulation and Parkinson's disease-like phenotype caused by anion channelrhodopsin opto-controlled astrocytic mitochondrial depolarization in substantia nigra pars compacta.
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism.
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease.
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III.
OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools.
Drosophila MIC10b can polymerize into cristae-shaping filaments.
MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy.
TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions.
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer.
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression.
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization.
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration.
Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE.
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.
Acute resistance exercise training does not augment mitochondrial remodelling in master athletes or untrained older adults.
DNA-PAINT MINFLUX nanoscopy.
ORP5/8 and MIB/MICOS link ER-mitochondria and intra-mitochondrial contacts for non-vesicular transport of phosphatidylserine.
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.
Resolution doubling in light-sheet microscopy via oblique plane structured illumination.
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
Optimal precision and accuracy in 4Pi-STORM using dynamic spline PSF models.
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation.
RIP3 Translocation into Mitochondria Promotes Mitofilin Degradation to Increase Inflammation and Kidney Injury after Renal Ischemia-Reperfusion.
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.
No effect of five days of bed rest or short-term resistance exercise prehabilitation on markers of skeletal muscle mitochondrial content and dynamics in older adults.
Proteomic Identification of the SLC25A46 Interactome in Transgenic Mice Expressing SLC25A46-FLAG.
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle.
The fasting-feeding metabolic transition regulates mitochondrial dynamics.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC.
Proximity Interactome Map of the Vac14-Fig4 Complex Using BioID.
The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels.
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Colocalization for super-resolution microscopy via optimal transport.
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes.
TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis.
Low abundance of Mfn2 protein correlates with reduced mitochondria-SR juxtaposition and mitochondrial cristae density in human men skeletal muscle: Examining organelle measurements from TEM images.
High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy.
Parkin interacts with Mitofilin to increase dopaminergic neuron death in response to Parkinson's disease-related stressors.
ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation.
Cardiac ischemia/reperfusion stress reduces inner mitochondrial membrane protein (mitofilin) levels during early reperfusion.
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle.
MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation.
Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.
Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.
Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent.
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.
Toxoplasma gondii MAF1b Binds the Host Cell MIB Complex To Mediate Mitochondrial Association.
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.
Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.
Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.
Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Suppression of Drug Resistance in Dengue Virus.
Megakaryocytic differentiation of K562 cells induced by PMA reduced the activity of respiratory chain complex IV.
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.
CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
Age-associated changes in synaptic lipid raft proteins revealed by two-dimensional fluorescence difference gel electrophoresis.
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Neurotransmitter accumulation and Parkinson's disease-like phenotype caused by anion channelrhodopsin opto-controlled astrocytic mitochondrial depolarization in substantia nigra pars compacta.
Li SM, Wang DD, Liu DH, Meng XY, Wang Z, Guo X, Liu Q, Liu PP, Li SA, Wang S, Yang RZ, Xu Y, Wang L, Kang JS
MedComm 2024 Jun;5(6):e568
MedComm 2024 Jun;5(6):e568
MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J
Cell 2024 Jul 11;187(14):3619-3637.e27
Cell 2024 Jul 11;187(14):3619-3637.e27
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Sun Y, Cao Y, Wan H, Memetimin A, Cao Y, Li L, Wu C, Wang M, Chen S, Li Q, Ma Y, Dong M, Jiang H
Molecular cell 2024 Jan 18;84(2):327-344.e9
Molecular cell 2024 Jan 18;84(2):327-344.e9
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism.
Maio G, Smith M, Bhawal R, Zhang S, Baskin JM, Li J, Lin H
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100709
Molecular & cellular proteomics : MCP 2024 Feb;23(2):100709
New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson's disease.
Romero-Zerbo SY, Valverde N, Claros S, Zamorano-Gonzalez P, Boraldi F, Lofaro FD, Lara E, Pavia J, Garcia-Fernandez M, Gago B, Martin-Montañez E
Journal of advanced research 2024 Feb 8;
Journal of advanced research 2024 Feb 8;
BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III.
Chen B, Lynn-Nguyen TM, Jadhav P, Halligan BS, Rossiter NJ, Guerra RM, Koshkin S, Koo I, Morlacchi P, Hanna DA, Lin J, Banerjee R, Pagliarini DJ, Patterson AD, Mosalaganti S, Sexton JZ, Calì T, Lyssiotis CA, Shah YM
bioRxiv : the preprint server for biology 2024 Feb 4;
bioRxiv : the preprint server for biology 2024 Feb 4;
OrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools.
Lee A, Sung G, Shin S, Lee SY, Sim J, Nhung TTM, Nghi TD, Park SK, Sathieshkumar PP, Kang I, Mun JY, Kim JS, Rhee HW, Park KM, Kim K
Nature communications 2024 Feb 29;15(1):1851
Nature communications 2024 Feb 29;15(1):1851
Drosophila MIC10b can polymerize into cristae-shaping filaments.
Stephan T, Stoldt S, Barbot M, Carney TD, Lange F, Bates M, Bou Dib P, Inamdar K, Shcherbata HR, Meinecke M, Riedel D, Dennerlein S, Rehling P, Jakobs S
Life science alliance 2024 Apr;7(4)
Life science alliance 2024 Apr;7(4)
MDM2 upregulation induces mitophagy deficiency via Mic60 ubiquitination in fetal microglial inflammation and consequently neuronal DNA damage caused by exposure to ZnO-NPs during pregnancy.
Zhang Y, Zhang Y, Lei Y, Wu J, Kang Y, Zheng S, Shao L
Journal of hazardous materials 2023 Sep 5;457:131750
Journal of hazardous materials 2023 Sep 5;457:131750
TRAP1 inhibits MARCH5-mediated MIC60 degradation to alleviate mitochondrial dysfunction and apoptosis of cardiomyocytes under diabetic conditions.
Zhang L, Luo Y, Lv L, Chen S, Liu G, Zhao T
Cell death and differentiation 2023 Oct;30(10):2336-2350
Cell death and differentiation 2023 Oct;30(10):2336-2350
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer.
Wang H, Liang Y, Zhang T, Yu X, Song X, Chen Y, Mao Q, Xia W, Chen B, Xu L, Dong G, Jiang F
Cell death and differentiation 2023 Nov;30(11):2365-2381
Cell death and differentiation 2023 Nov;30(11):2365-2381
SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation.
Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S
Basic research in cardiology 2023 May 22;118(1):20
Basic research in cardiology 2023 May 22;118(1):20
Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression.
Sun Y, Xiao W, Yu Y, Jiang Y, Xiao Z, Huang D, Zhong T, Li J, Xiang X, He Y, Li Z
Experimental cell research 2023 May 15;426(2):113565
Experimental cell research 2023 May 15;426(2):113565
A mitochondrial SCF-FBXL4 ubiquitin E3 ligase complex degrades BNIP3 and NIX to restrain mitophagy and prevent mitochondrial disease.
Cao Y, Zheng J, Wan H, Sun Y, Fu S, Liu S, He B, Cai G, Cao Y, Huang H, Li Q, Ma Y, Chen S, Wang F, Jiang H
The EMBO journal 2023 Jul 3;42(13):e113033
The EMBO journal 2023 Jul 3;42(13):e113033
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization.
Zheng Z, Han L, Li Y, Chen Z, Yang W, Liu C, Tao M, Jiang Y, Ke X, Liu Y, Guo X
Biochimica et biophysica acta. Molecular cell research 2023 Aug;1870(6):119487
Biochimica et biophysica acta. Molecular cell research 2023 Aug;1870(6):119487
Liver mitochondrial cristae organizing protein MIC19 promotes energy expenditure and pedestrian locomotion by altering nucleotide metabolism.
Sohn JH, Mutlu B, Latorre-Muro P, Liang J, Bennett CF, Sharabi K, Kantorovich N, Jedrychowski M, Gygi SP, Banks AS, Puigserver P
Cell metabolism 2023 Aug 8;35(8):1356-1372.e5
Cell metabolism 2023 Aug 8;35(8):1356-1372.e5
Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration.
Wang Z, Wei D, Bin E, Li J, Jiang K, Lv T, Mao X, Wang F, Dai H, Tang N
Cell stem cell 2023 Aug 3;30(8):1028-1042.e7
Cell stem cell 2023 Aug 3;30(8):1028-1042.e7
Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE.
Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative*
Molecular psychiatry 2023 Apr;28(4):1813-1826
Molecular psychiatry 2023 Apr;28(4):1813-1826
The outer mitochondrial membrane protein TMEM11 demarcates spatially restricted BNIP3/BNIP3L-mediated mitophagy.
Gok MO, Connor OM, Wang X, Menezes CJ, Llamas CB, Mishra P, Friedman JR
The Journal of cell biology 2023 Apr 3;222(4)
The Journal of cell biology 2023 Apr 3;222(4)
Inner mitochondrial membrane structure and fusion dynamics are altered in senescent human iPSC-derived and primary rat cardiomyocytes.
Morris S, Molina-Riquelme I, Barrientos G, Bravo F, Aedo G, Gómez W, Lagos D, Verdejo H, Peischard S, Seebohm G, Psathaki OE, Eisner V, Busch KB
Biochimica et biophysica acta. Bioenergetics 2023 Apr 1;1864(2):148949
Biochimica et biophysica acta. Bioenergetics 2023 Apr 1;1864(2):148949
Acute resistance exercise training does not augment mitochondrial remodelling in master athletes or untrained older adults.
Marshall RN, McKendry J, Smeuninx B, Seabright AP, Morgan PT, Greig C, Breen L
Frontiers in physiology 2022;13:1097988
Frontiers in physiology 2022;13:1097988
DNA-PAINT MINFLUX nanoscopy.
Ostersehlt LM, Jans DC, Wittek A, Keller-Findeisen J, Inamdar K, Sahl SJ, Hell SW, Jakobs S
Nature methods 2022 Sep;19(9):1072-1075
Nature methods 2022 Sep;19(9):1072-1075
ORP5/8 and MIB/MICOS link ER-mitochondria and intra-mitochondrial contacts for non-vesicular transport of phosphatidylserine.
Monteiro-Cardoso VF, Rochin L, Arora A, Houcine A, Jääskeläinen E, Kivelä AM, Sauvanet C, Le Bars R, Marien E, Dehairs J, Neveu J, El Khallouki N, Santonico E, Swinnen JV, Tareste D, Olkkonen VM, Giordano F
Cell reports 2022 Sep 20;40(12):111364
Cell reports 2022 Sep 20;40(12):111364
Loss of Sam50 in hepatocytes induces cardiolipin-dependent mitochondrial membrane remodeling to trigger mtDNA release and liver injury.
Chen L, Dong J, Liao S, Wang S, Wu Z, Zuo M, Liu B, Yan C, Chen Y, He H, Meng Q, Song Z
Hepatology (Baltimore, Md.) 2022 Nov;76(5):1389-1408
Hepatology (Baltimore, Md.) 2022 Nov;76(5):1389-1408
Resolution doubling in light-sheet microscopy via oblique plane structured illumination.
Chen B, Chang BJ, Roudot P, Zhou F, Sapoznik E, Marlar-Pavey M, Hayes JB, Brown PT, Zeng CW, Lambert T, Friedman JR, Zhang CL, Burnette DT, Shepherd DP, Dean KM, Fiolka RP
Nature methods 2022 Nov;19(11):1419-1426
Nature methods 2022 Nov;19(11):1419-1426
Mitochondrial membrane proteins and VPS35 orchestrate selective removal of mtDNA.
Sen A, Kallabis S, Gaedke F, Jüngst C, Boix J, Nüchel J, Maliphol K, Hofmann J, Schauss AC, Krüger M, Wiesner RJ, Pla-Martín D
Nature communications 2022 Nov 7;13(1):6704
Nature communications 2022 Nov 7;13(1):6704
Optimal precision and accuracy in 4Pi-STORM using dynamic spline PSF models.
Bates M, Keller-Findeisen J, Przybylski A, Hüper A, Stephan T, Ilgen P, Cereceda Delgado AR, D'Este E, Egner A, Jakobs S, Sahl SJ, Hell SW
Nature methods 2022 May;19(5):603-612
Nature methods 2022 May;19(5):603-612
The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation.
Cosentino K, Hertlein V, Jenner A, Dellmann T, Gojkovic M, Peña-Blanco A, Dadsena S, Wajngarten N, Danial JSH, Thevathasan JV, Mund M, Ries J, Garcia-Saez AJ
Molecular cell 2022 Mar 3;82(5):933-949.e9
Molecular cell 2022 Mar 3;82(5):933-949.e9
RIP3 Translocation into Mitochondria Promotes Mitofilin Degradation to Increase Inflammation and Kidney Injury after Renal Ischemia-Reperfusion.
Feng Y, Imam Aliagan A, Tombo N, Draeger D, Bopassa JC
Cells 2022 Jun 11;11(12)
Cells 2022 Jun 11;11(12)
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.
Ledahawsky LM, Terzenidou ME, Edwards R, Kline RA, Graham LC, Eaton SL, van der Hoorn D, Chaytow H, Huang YT, Groen EJN, Motyl AAL, Lamont DJ, Tokatlidis K, Wishart TM, Gillingwater TH
The FEBS journal 2022 Jul;289(13):3894-3914
The FEBS journal 2022 Jul;289(13):3894-3914
No effect of five days of bed rest or short-term resistance exercise prehabilitation on markers of skeletal muscle mitochondrial content and dynamics in older adults.
Marshall RN, Smeuninx B, Seabright AP, Morgan PT, Atherton PJ, Philp A, Breen L
Physiological reports 2022 Jul;10(13):e15345
Physiological reports 2022 Jul;10(13):e15345
Proteomic Identification of the SLC25A46 Interactome in Transgenic Mice Expressing SLC25A46-FLAG.
Perivolidi VI, Violitzi F, Ioannidou E, Rinotas V, Stamatakis G, Samiotaki M, Panayotou G, Douni E
Journal of proteome research 2022 Feb 4;21(2):375-394
Journal of proteome research 2022 Feb 4;21(2):375-394
Mitochondrial cristae architecture protects against mtDNA release and inflammation.
He B, Yu H, Liu S, Wan H, Fu S, Liu S, Yang J, Zhang Z, Huang H, Li Q, Wang F, Jiang Z, Liu Q, Jiang H
Cell reports 2022 Dec 6;41(10):111774
Cell reports 2022 Dec 6;41(10):111774
Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle.
Lu X, Gong Y, Hu W, Mao Y, Wang T, Sun Z, Su X, Fu G, Wang Y, Lai D
Cell death & disease 2022 Apr 2;13(4):296
Cell death & disease 2022 Apr 2;13(4):296
The fasting-feeding metabolic transition regulates mitochondrial dynamics.
Castro-Sepúlveda M, Morio B, Tuñón-Suárez M, Jannas-Vela S, Díaz-Castro F, Rieusset J, Zbinden-Foncea H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21891
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Oct;35(10):e21891
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC.
Liu YT, Sliter DA, Shammas MK, Huang X, Wang C, Calvelli H, Maric DS, Narendra DP
Autophagy 2021 Nov;17(11):3753-3762
Autophagy 2021 Nov;17(11):3753-3762
Proximity Interactome Map of the Vac14-Fig4 Complex Using BioID.
Qiu S, Lavallée-Adam M, Côté M
Journal of proteome research 2021 Nov 5;20(11):4959-4973
Journal of proteome research 2021 Nov 5;20(11):4959-4973
The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels.
Brüser C, Keller-Findeisen J, Jakobs S
Cell reports 2021 Nov 23;37(8):110000
Cell reports 2021 Nov 23;37(8):110000
Discovery of bactericides as an acute mitochondrial membrane damage inducer.
Houston R, Sekine Y, Larsen MB, Murakami K, Mullett SJ, Wendell SG, Narendra DP, Chen BB, Sekine S
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Molecular biology of the cell 2021 Nov 1;32(21):ar32
Colocalization for super-resolution microscopy via optimal transport.
Tameling C, Stoldt S, Stephan T, Naas J, Jakobs S, Munk A
Nature computational science 2021 Mar;1:199-211
Nature computational science 2021 Mar;1:199-211
A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Latorre-Muro P, O'Malley KE, Bennett CF, Perry EA, Balsa E, Tavares CDJ, Jedrychowski M, Gygi SP, Puigserver P
Cell metabolism 2021 Mar 2;33(3):598-614.e7
Cell metabolism 2021 Mar 2;33(3):598-614.e7
Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes.
Ma JY, Feng X, Xie FY, Li S, Chen LN, Luo SM, Yin S, Ou XH
Genetics 2021 Jun 24;218(2)
Genetics 2021 Jun 24;218(2)
TRAP1 inhibits MIC60 ubiquitination to mitigate the injury of cardiomyocytes and protect mitochondria in extracellular acidosis.
Zhang L, Su N, Luo Y, Chen S, Zhao T
Cell death discovery 2021 Dec 14;7(1):389
Cell death discovery 2021 Dec 14;7(1):389
Low abundance of Mfn2 protein correlates with reduced mitochondria-SR juxtaposition and mitochondrial cristae density in human men skeletal muscle: Examining organelle measurements from TEM images.
Castro-Sepulveda M, Fernández-Verdejo R, Tuñón-Suárez M, Morales-Zúñiga J, Troncoso M, Jannas-Vela S, Zbinden-Foncea H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21553
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21553
High-Resolution Imaging of Tumor Spheroids and Organoids Enabled by Expansion Microscopy.
Edwards SJ, Carannante V, Kuhnigk K, Ring H, Tararuk T, Hallböök F, Blom H, Önfelt B, Brismar H
Frontiers in molecular biosciences 2020;7:208
Frontiers in molecular biosciences 2020;7:208
Parkin interacts with Mitofilin to increase dopaminergic neuron death in response to Parkinson's disease-related stressors.
Imam Aliagan AD, Ahwazi MD, Tombo N, Feng Y, Bopassa JC
American journal of translational research 2020;12(11):7542-7564
American journal of translational research 2020;12(11):7542-7564
ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation.
Qin J, Guo Y, Xue B, Shi P, Chen Y, Su QP, Hao H, Zhao S, Wu C, Yu L, Li D, Sun Y
Nature communications 2020 Sep 8;11(1):4471
Nature communications 2020 Sep 8;11(1):4471
Cardiac ischemia/reperfusion stress reduces inner mitochondrial membrane protein (mitofilin) levels during early reperfusion.
Tombo N, Imam Aliagan AD, Feng Y, Singh H, Bopassa JC
Free radical biology & medicine 2020 Oct;158:181-194
Free radical biology & medicine 2020 Oct;158:181-194
OPA1 and MICOS Regulate mitochondrial crista dynamics and formation.
Hu C, Shu L, Huang X, Yu J, Li L, Gong L, Yang M, Wu Z, Gao Z, Zhao Y, Chen L, Song Z
Cell death & disease 2020 Oct 31;11(10):940
Cell death & disease 2020 Oct 31;11(10):940
Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Liu YT, Huang X, Nguyen D, Shammas MK, Wu BP, Dombi E, Springer DA, Poulton J, Sekine S, Narendra DP
Human molecular genetics 2020 Jun 3;29(9):1547-1567
Human molecular genetics 2020 Jun 3;29(9):1547-1567
β-Hydroxybutyrate Increases Exercise Capacity Associated with Changes in Mitochondrial Function in Skeletal Muscle.
Monsalves-Alvarez M, Morales PE, Castro-Sepulveda M, Sepulveda C, Rodriguez JM, Chiong M, Eisner V, Lavandero S, Troncoso R
Nutrients 2020 Jun 29;12(7)
Nutrients 2020 Jun 29;12(7)
MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation.
Stephan T, Brüser C, Deckers M, Steyer AM, Balzarotti F, Barbot M, Behr TS, Heim G, Hübner W, Ilgen P, Lange F, Pacheu-Grau D, Pape JK, Stoldt S, Huser T, Hell SW, Möbius W, Rehling P, Riedel D, Jakobs S
The EMBO journal 2020 Jul 15;39(14):e104105
The EMBO journal 2020 Jul 15;39(14):e104105
Sam50-Mic19-Mic60 axis determines mitochondrial cristae architecture by mediating mitochondrial outer and inner membrane contact.
Tang J, Zhang K, Dong J, Yan C, Hu C, Ji H, Chen L, Chen S, Zhao H, Song Z
Cell death and differentiation 2020 Jan;27(1):146-160
Cell death and differentiation 2020 Jan;27(1):146-160
Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression.
Ayanlaja AA, Ji G, Wang J, Gao Y, Cheng B, Kanwore K, Zhang L, Xiong Y, Kambey PA, Gao D
Cell communication and signaling : CCS 2020 Feb 12;18(1):24
Cell communication and signaling : CCS 2020 Feb 12;18(1):24
Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Murata D, Yamada T, Tokuyama T, Arai K, Quirós PM, López-Otín C, Iijima M, Sesaki H
The EMBO journal 2020 Dec 15;39(24):e105074
The EMBO journal 2020 Dec 15;39(24):e105074
Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis.
Choi UY, Lee JJ, Park A, Zhu W, Lee HR, Choi YJ, Yoo JS, Yu C, Feng P, Gao SJ, Chen S, Eoh H, Jung JU
Proceedings of the National Academy of Sciences of the United States of America 2020 Apr 7;117(14):8083-8093
Proceedings of the National Academy of Sciences of the United States of America 2020 Apr 7;117(14):8083-8093
Individual cristae within the same mitochondrion display different membrane potentials and are functionally independent.
Wolf DM, Segawa M, Kondadi AK, Anand R, Bailey ST, Reichert AS, van der Bliek AM, Shackelford DB, Liesa M, Shirihai OS
The EMBO journal 2019 Nov 15;38(22):e101056
The EMBO journal 2019 Nov 15;38(22):e101056
Mapping Interactome Networks of DNAJC11, a Novel Mitochondrial Protein Causing Neuromuscular Pathology in Mice.
Violitzi F, Perivolidi VI, Thireou T, Grivas I, Haralambous S, Samiotaki M, Panayotou G, Douni E
Journal of proteome research 2019 Nov 1;18(11):3896-3912
Journal of proteome research 2019 Nov 1;18(11):3896-3912
TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
Wang P, Deng J, Dong J, Liu J, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AY, McGee WA, Chen X, Fushimi K, Zhu L, Wu JY
PLoS genetics 2019 May;15(5):e1007947
PLoS genetics 2019 May;15(5):e1007947
ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2α Axis.
Balsa E, Soustek MS, Thomas A, Cogliati S, García-Poyatos C, Martín-García E, Jedrychowski M, Gygi SP, Enriquez JA, Puigserver P
Molecular cell 2019 Jun 6;74(5):877-890.e6
Molecular cell 2019 Jun 6;74(5):877-890.e6
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis.
Dovey CM, Diep J, Clarke BP, Hale AT, McNamara DE, Guo H, Brown NW Jr, Cao JY, Grace CR, Gough PJ, Bertin J, Dixon SJ, Fiedler D, Mocarski ES, Kaiser WJ, Moldoveanu T, York JD, Carette JE
Molecular cell 2018 Jun 7;70(5):936-948.e7
Molecular cell 2018 Jun 7;70(5):936-948.e7
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
Jian F, Chen D, Chen L, Yan C, Lu B, Zhu Y, Chen S, Shi A, Chan DC, Song Z
Cell reports 2018 Jun 5;23(10):2989-3005
Cell reports 2018 Jun 5;23(10):2989-3005
Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS.
Straub IR, Janer A, Weraarpachai W, Zinman L, Robertson J, Rogaeva E, Shoubridge EA
Human molecular genetics 2018 Jan 1;27(1):178-189
Human molecular genetics 2018 Jan 1;27(1):178-189
Toxoplasma gondii MAF1b Binds the Host Cell MIB Complex To Mediate Mitochondrial Association.
Kelly FD, Wei BM, Cygan AM, Parker ML, Boulanger MJ, Boothroyd JC
mSphere 2017 May-Jun;2(3)
mSphere 2017 May-Jun;2(3)
Rapid degradation of mutant SLC25A46 by the ubiquitin-proteasome system results in MFN1/2-mediated hyperfusion of mitochondria.
Steffen J, Vashisht AA, Wan J, Jen JC, Claypool SM, Wohlschlegel JA, Koehler CM
Molecular biology of the cell 2017 Mar 1;28(5):600-612
Molecular biology of the cell 2017 Mar 1;28(5):600-612
Novel insights into SLC25A46-related pathologies in a genetic mouse model.
Terzenidou ME, Segklia A, Kano T, Papastefanaki F, Karakostas A, Charalambous M, Ioakeimidis F, Papadaki M, Kloukina I, Chrysanthou-Piterou M, Samiotaki M, Panayotou G, Matsas R, Douni E
PLoS genetics 2017 Apr;13(4):e1006656
PLoS genetics 2017 Apr;13(4):e1006656
Mic60/Mitofilin determines MICOS assembly essential for mitochondrial dynamics and mtDNA nucleoid organization.
Li H, Ruan Y, Zhang K, Jian F, Hu C, Miao L, Gong L, Sun L, Zhang X, Chen S, Chen H, Liu D, Song Z
Cell death and differentiation 2016 Mar;23(3):380-92
Cell death and differentiation 2016 Mar;23(3):380-92
CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.
Genin EC, Plutino M, Bannwarth S, Villa E, Cisneros-Barroso E, Roy M, Ortega-Vila B, Fragaki K, Lespinasse F, Pinero-Martos E, Augé G, Moore D, Burté F, Lacas-Gervais S, Kageyama Y, Itoh K, Yu-Wai-Man P, Sesaki H, Ricci JE, Vives-Bauza C, Paquis-Flucklinger V
EMBO molecular medicine 2016 Jan 1;8(1):58-72
EMBO molecular medicine 2016 Jan 1;8(1):58-72
Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology.
Wang Y, Wu F, Pan H, Zheng W, Feng C, Wang Y, Deng Z, Wang L, Luo J, Chen S
Scientific reports 2016 Feb 29;6:22244
Scientific reports 2016 Feb 29;6:22244
Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.
Zeharia A, Friedman JR, Tobar A, Saada A, Konen O, Fellig Y, Shaag A, Nunnari J, Elpeleg O
European journal of human genetics : EJHG 2016 Dec;24(12):1778-1782
European journal of human genetics : EJHG 2016 Dec;24(12):1778-1782
Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control.
Glytsou C, Calvo E, Cogliati S, Mehrotra A, Anastasia I, Rigoni G, Raimondi A, Shintani N, Loureiro M, Vazquez J, Pellegrini L, Enriquez JA, Scorrano L, Soriano ME
Cell reports 2016 Dec 13;17(11):3024-3034
Cell reports 2016 Dec 13;17(11):3024-3034
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.
Petrungaro C, Zimmermann KM, Küttner V, Fischer M, Dengjel J, Bogeski I, Riemer J
Cell metabolism 2015 Oct 6;22(4):721-33
Cell metabolism 2015 Oct 6;22(4):721-33
Mitofilin and CHCHD6 physically interact with Sam50 to sustain cristae structure.
Ding C, Wu Z, Huang L, Wang Y, Xue J, Chen S, Deng Z, Wang L, Song Z, Chen S
Scientific reports 2015 Nov 4;5:16064
Scientific reports 2015 Nov 4;5:16064
Suppression of Drug Resistance in Dengue Virus.
Mateo R, Nagamine CM, Kirkegaard K
mBio 2015 Dec 15;6(6):e01960-15
mBio 2015 Dec 15;6(6):e01960-15
Megakaryocytic differentiation of K562 cells induced by PMA reduced the activity of respiratory chain complex IV.
Huang R, Zhao L, Chen H, Yin RH, Li CY, Zhan YQ, Zhang JH, Ge CH, Yu M, Yang XM
PloS one 2014;9(5):e96246
PloS one 2014;9(5):e96246
The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.
Anand R, Wai T, Baker MJ, Kladt N, Schauss AC, Rugarli E, Langer T
The Journal of cell biology 2014 Mar 17;204(6):919-29
The Journal of cell biology 2014 Mar 17;204(6):919-29
A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.
Bannwarth S, Ait-El-Mkadem S, Chaussenot A, Genin EC, Lacas-Gervais S, Fragaki K, Berg-Alonso L, Kageyama Y, Serre V, Moore DG, Verschueren A, Rouzier C, Le Ber I, Augé G, Cochaud C, Lespinasse F, N'Guyen K, de Septenville A, Brice A, Yu-Wai-Man P, Sesaki H, Pouget J, Paquis-Flucklinger V
Brain : a journal of neurology 2014 Aug;137(Pt 8):2329-45
Brain : a journal of neurology 2014 Aug;137(Pt 8):2329-45
CHCM1/CHCHD6, novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology.
An J, Shi J, He Q, Lui K, Liu Y, Huang Y, Sheikh MS
The Journal of biological chemistry 2012 Mar 2;287(10):7411-26
The Journal of biological chemistry 2012 Mar 2;287(10):7411-26
Age-associated changes in synaptic lipid raft proteins revealed by two-dimensional fluorescence difference gel electrophoresis.
Jiang L, Fang J, Moore DS, Gogichaeva NV, Galeva NA, Michaelis ML, Zaidi A
Neurobiology of aging 2010 Dec;31(12):2146-59
Neurobiology of aging 2010 Dec;31(12):2146-59
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ
Biochemistry 2009 Mar 10;48(9):2045-52
Biochemistry 2009 Mar 10;48(9):2045-52
Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells.
Yin X, Mayr M, Xiao Q, Wang W, Xu Q
Proteomics 2006 Dec;6(24):6437-46
Proteomics 2006 Dec;6(24):6437-46
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Mitofilin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Mitofilin. This antibody recognizes human, mouse antigen. The Mitofilin antibody has been validated for the following applications: ELISA, IHC, IF, WB, IP analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using IMMT antibody 10179-1-AP at 1:50 dilution and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IMMT (IP:10179-1-AP, 3ug; Detection:10179-1-AP 1:1000) with Raji cells lysate 3800ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 10179-1-AP(IMMT antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human gliomas using 10179-1-AP(IMMT antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
