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- References [465]
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- Product number
- 17711-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17711-1-AP, RRID:AB_2060867
- Product name
- ARL13B antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ARL13B antibody (Cat. #17711-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies.
Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis.
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding.
Centriolar Protein C2cd3 Is Required for Craniofacial Development.
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Loss of Ciliary Gene Bbs8 Results in Physiological Defects in the Retinal Pigment Epithelium.
Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis.
Primary Cilia as a Biomarker in Mesenchymal Stem Cells Senescence: Influencing Osteoblastic Differentiation Potency Associated with Hedgehog Signaling Regulation.
Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.
Primary Cilia Mediate TSH-Regulated Thyroglobulin Endocytic Pathways.
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.
Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome in Experimental Endotoxemia.
Cilium induction triggers differentiation of glioma stem cells.
2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells.
A ciliopathy complex builds distal appendages to initiate ciliogenesis.
MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis.
Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles.
Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement.
Identification of disease-relevant modulators of the SHH pathway in the developing brain.
Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion.
DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.
Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.
Human brain organoids assemble functionally integrated bilateral optic vesicles.
Induction of inverted morphology in brain organoids by vertical-mixing bioreactors.
Ciliary Hedgehog signaling regulates cell survival to build the facial midline.
Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model.
Δ9-Tetrahydrocannabinol inhibits Hedgehog-dependent patterning during development.
Gene replacement therapy restores RCBTB1 expression and cilium length in patient-derived retinal pigment epithelium.
Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity.
Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy.
Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.
Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase.
Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function.
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Deletion of Sox9 in the liver leads to hepatic cystogenesis in mice by transcriptionally downregulating Sec63.
De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.
Time-resolved proteomics profiling of the ciliary Hedgehog response.
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.
Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis.
CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images.
Investigating Primary Cilia during Peripheral Nervous System Formation.
Identification of a potent antagonist of smoothened in hedgehog signaling.
Sub-toxic levels of cobalt ions impair chondrocyte mechanostranduction via HDAC6-dependent primary cilia shortening.
Exovesicular-Shh confers Imatinib resistance by upregulating Bcl2 expression in chronic myeloid leukemia with variant chromosomes.
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis.
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis.
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response.
Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons.
Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle.
Identification of Cilia in Different Mouse Tissues.
Modeling retinitis pigmentosa through patient-derived retinal organoids.
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.
Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells.
TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.
Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms.
CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.
Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
Rab34 is necessary for early stages of intracellular ciliogenesis.
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7.
TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection.
DAB2IP modulates primary cilia formation associated with renal tumorigenesis.
Nonredundant roles of DIAPHs in primary ciliogenesis.
BBS Proteins Affect Ciliogenesis and Are Essential for Hedgehog Signaling, but Not for Formation of iPSC-Derived RPE-65 Expressing RPE-Like Cells.
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.
Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
Application of green tea catechins, polysaccharides, and flavonol prevent fine dust induced bronchial damage by modulating inflammation and airway cilia.
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis.
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Functional inhibition of fatty acid binding protein 4 ameliorates impaired ciliogenesis in GCs.
Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer.
Expression of α-Tubulin Acetyltransferase 1 and Tubulin Acetylation as Selective Forces in Cell Competition.
CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development.
The 3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase EBP inhibits cholesterylation of Smoothened.
Cisplatin induces lung cell cilia disruption and lung damage via oxidative stress.
Exocyst complex mediates recycling of internal cilia.
Biallelic deep intronic variant c.5457+81T>A in TRIP11 causes loss of function and results in achondrogenesis 1A.
Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.
Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.
Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD.
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.
A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.
Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress.
Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.
Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.
A CRISPR and high-content imaging assay compliant with ACMG/AMP guidelines for clinical variant interpretation in ciliopathies.
A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities.
WDR35 is involved in subcellular localization of acetylated tubulin in 293T cells.
The N-terminal Leu-Pro-Gln sequence of Rab34 is required for ciliogenesis in hTERT-RPE1 cells.
Roles for ELMOD2 and Rootletin in ciliogenesis.
Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone.
A ZFYVE19 gene mutation associated with neonatal cholestasis and cilia dysfunction: case report with a novel pathogenic variant.
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
Characterization of primary cilia features reveal cell-type specific variability in in vitro models of osteogenic and chondrogenic differentiation.
FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly.
Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells.
CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells.
Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1.
Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa.
Analysis of Caveolin in Primary Cilia.
A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells.
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
Loss of Cilia Does Not Slow Liver Disease Progression in Mouse Models of Autosomal Recessive Polycystic Kidney Disease.
Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2.
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.
Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development.
Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.
Primary cilia mediate parathyroid hormone receptor type 1 osteogenic actions in osteocytes and osteoblasts via Gli activation.
Mutations in the exocyst component EXOC2 cause severe defects in human brain development.
A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia.
Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.
Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles.
Differentiation of ciliated human midbrain-derived LUHMES neurons.
Centrosome and ciliary abnormalities in fetal akinesia deformation sequence human fibroblasts.
Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.
LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus.
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.
Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease.
Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.
ECE2 regulates neurogenesis and neuronal migration during human cortical development.
TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.
Profilin1-Dependent F-Actin Assembly Controls Division of Apical Radial Glia and Neocortex Development.
Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.
ARL13B regulates Sonic hedgehog signaling from outside primary cilia.
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis.
Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy.
Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
A novel CDK-independent function of p27Kip1 in preciliary vesicle trafficking during ciliogenesis.
Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.
Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly.
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
Robust classification of cell cycle phase and biological feature extraction by image-based deep learning.
Intracellular calcium response of primary cilia of tubular cells to modulated shear stress under oxidative stress.
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.
Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.
Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.
Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control.
Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.
Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD.
Intraflagellar-transport A dysfunction causes hyperphagia-induced systemic insulin resistance in a pre-obese state.
ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
CENPV Is a CYLD-Interacting Molecule Regulating Ciliary Acetylated α-Tubulin.
hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning.
The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis.
MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress.
TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation.
Nubp2 is required for cranial neural crest survival in the mouse.
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
DIAPH1 regulates ciliogenesis and trafficking in primary cilia.
Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.
Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes.
Sonic hedgehog signalling as a potential endobronchial biomarker in COPD.
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling.
An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics.
Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome.
An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration.
A reduction of primary cilia but not hedgehog signaling disrupts morphogenesis in testicular organoids.
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
The HOPS complex subunit VPS39 controls ciliogenesis through autophagy.
The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts.
Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.
Ocular Ciliopathies: Genetic and Mechanistic Insights into Developing Therapies.
Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish.
Induction of Neural Crest Stem Cells From Bardet-Biedl Syndrome Patient Derived hiPSCs.
661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.
Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation.
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia.
Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.
Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.
Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.
Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
microRNAs Regulating Human and Mouse Naïve Pluripotency.
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma.
Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells.
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.
Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants.
Indian Hedgehog links obesity to development of hepatocellular carcinoma.
Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes.
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.
Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.
HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development.
Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.
The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling.
Elevated miR-200a and miR-141 inhibit endocrine gland-derived vascular endothelial growth factor expression and ciliogenesis in preeclampsia.
Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression.
Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis.
Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons.
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation.
Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued.
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.
Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.
Spastin Contributes to Neural Development through the Regulation of Microtubule Dynamics in the Primary Cilia of Neural Stem Cells.
Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs.
CCDC114 is mutated in patient with a complex phenotype combining primary ciliary dyskinesia, sensorineural deafness, and renal disease.
Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines.
Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation.
Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.
Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.
Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl-]i in mouse airway cilia.
Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland.
Recycling endosomal CD133 functions as an inhibitor of autophagy at the pericentrosomal region.
Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases.
Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse.
Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/- iPSC-Derived RPE Cells.
Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells - A novel source of urinary biomarkers of renal injury.
HDAC3 and HDAC8 are required for cilia assembly and elongation.
Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.
Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity.
A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.
Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion.
Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase.
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.
Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development.
Tubular flow activates magnesium transport in the distal convoluted tubule.
The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.
CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis.
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.
Adenylyl cyclases and TRPV4 mediate Ca2+/cAMP dynamics to enhance fluid flow-induced osteogenesis in osteocytes.
Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.
Dorsoventral differences in cAMP levels and correlated changes in the subcellular distribution of the PKA catalytic domain, provide further evidence that PKA signaling coordinates dorsoventral patterning of the otocyst.
A distal centriolar protein network controls organelle maturation and asymmetry.
LRRC45 contributes to early steps of axoneme extension.
A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy.
Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa.
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.
The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.
Membrane association and remodeling by intraflagellar transport protein IFT172.
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.
Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice.
Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain.
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.
Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.
Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.
Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.
Autophagy alteration prevents primary cilium disassembly in RPE1 cells.
Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.
Primary cilia-regulated transcriptome in the renal collecting duct.
CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.
EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.
Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.
Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development.
Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition.
DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
Reconstructing the Human Renal Vascular-Tubular Unit In Vitro.
Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.
Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size.
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.
Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.
Centrobin controls primary ciliogenesis in vertebrates.
Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.
Abnormal glycosylation in Joubert syndrome type 10.
Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.
Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.
Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.
The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.
CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.
GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.
Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome.
A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.
Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division.
Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.
An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations.
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.
Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.
Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.
SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.
Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.
Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
Guided self-organization and cortical plate formation in human brain organoids.
Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis.
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.
Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.
Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.
A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.
Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.
An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.
The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.
A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.
Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
A novel role for primary cilia in airway remodeling.
Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro.
Estrogen receptor α is required for oviductal transport of embryos.
Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency.
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
Cilia-dependent GLI processing in neural crest cells is required for tongue development.
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders.
Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system.
A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.
Measuring the primary cilium length: improved method for unbiased high-throughput analysis.
Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation.
Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy.
Methods for Visualization of Neuronal Cilia.
Targeting of ASH Domain-Containing Proteins to the Centrosome.
Immunofluorescent staining of septins in primary cilia.
Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model.
KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome.
Nestin Mediates Hedgehog Pathway Tumorigenesis.
RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.
IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome.
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.
Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.
Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.
Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.
Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.
MKS1 regulates ciliary INPP5E levels in Joubert syndrome.
TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.
Arl13b and the exocyst interact synergistically in ciliogenesis.
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling.
NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.
Endothelial primary cilia inhibit atherosclerosis.
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.
Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.
Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish.
Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.
CPAP promotes timely cilium disassembly to maintain neural progenitor pool.
Culture and detection of primary cilia in endothelial cell models.
Analysis of primary cilia in the developing mouse brain.
Imaging centrosomes and cilia in the mouse kidney.
A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.
Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome.
Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.
Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.
PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism.
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.
The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Loss of primary cilia in melanoma cells is likely independent of proliferation and cell cycle progression.
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.
Centrin2 regulates CP110 removal in primary cilium formation.
The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition.
Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis.
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.
Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes.
The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.
A role for Rab23 in the trafficking of Kif17 to the primary cilium.
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.
BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.
Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.
A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.
Primary cilia in the developing pig testis.
A homozygous missense mutation in the ciliary gene TTC21B causes familial FSGS.
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
RFX7 is required for the formation of cilia in the neural tube.
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.
SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.
Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion.
Basal body proteins regulate Notch signaling through endosomal trafficking.
Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division.
Arhgap36-dependent activation of Gli transcription factors.
Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.
Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy.
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.
The ciliary protein Ftm is required for ventricular wall and septal development.
Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.
Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division.
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.
Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.
Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys.
Visualizing renal primary cilia.
VDAC3 and Mps1 negatively regulate ciliogenesis.
Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis.
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.
Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.
CCDC41 is required for ciliary vesicle docking to the mother centriole.
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination.
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Rosa E Silva I, Binó L, Johnson CM, Rutherford TJ, Neuhaus D, Andreeva A, Čajánek L, van Breugel M
Structure (London, England : 1993) 2022 Jan 6;30(1):114-128.e9
Structure (London, England : 1993) 2022 Jan 6;30(1):114-128.e9
Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis.
Ungricht R, Guibbal L, Lasbennes MC, Orsini V, Beibel M, Waldt A, Cuttat R, Carbone W, Basler A, Roma G, Nigsch F, Tchorz JS, Hoepfner D, Hoppe PS
Cell stem cell 2022 Jan 6;29(1):160-175.e7
Cell stem cell 2022 Jan 6;29(1):160-175.e7
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Shen XL, Yuan JF, Qin XH, Song GP, Hu HB, Tu HQ, Song ZQ, Li PY, Xu YL, Li S, Jian XX, Li JN, He CY, Yu XP, Liang LY, Wu M, Han QY, Wang K, Li AL, Zhou T, Zhang YC, Wang N, Li HY
The Journal of cell biology 2022 Jan 3;221(1)
The Journal of cell biology 2022 Jan 3;221(1)
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding.
Yue Y, Engelke MF, Blasius TL, Verhey KJ
Molecular biology of the cell 2022 Jan 1;33(1):br1
Molecular biology of the cell 2022 Jan 1;33(1):br1
Centriolar Protein C2cd3 Is Required for Craniofacial Development.
Chang CF, Brown KM, Yang Y, Brugmann SA
Frontiers in cell and developmental biology 2021;9:647391
Frontiers in cell and developmental biology 2021;9:647391
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Bernatik O, Paclikova P, Kotrbova A, Bryja V, Cajanek L
Frontiers in cell and developmental biology 2021;9:623753
Frontiers in cell and developmental biology 2021;9:623753
Loss of Ciliary Gene Bbs8 Results in Physiological Defects in the Retinal Pigment Epithelium.
Schneider S, De Cegli R, Nagarajan J, Kretschmer V, Matthiessen PA, Intartaglia D, Hotaling N, Ueffing M, Boldt K, Conte I, May-Simera HL
Frontiers in cell and developmental biology 2021;9:607121
Frontiers in cell and developmental biology 2021;9:607121
Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis.
Tripathi P, Zhu Z, Qin H, Elsherbini A, Crivelli SM, Roush E, Wang G, Spassieva SD, Bieberich E
Journal of lipid research 2021;62:100021
Journal of lipid research 2021;62:100021
Primary Cilia as a Biomarker in Mesenchymal Stem Cells Senescence: Influencing Osteoblastic Differentiation Potency Associated with Hedgehog Signaling Regulation.
Fu S, Zhang C, Yan X, Li D, Wang Y, Dong C, Cao Z, Ning Y, Shao C, Yang T
Stem cells international 2021;2021:8850114
Stem cells international 2021;2021:8850114
Differential requirement of NPHP1 for compartmentalized protein localization during photoreceptor outer segment development and maintenance.
Datta P, Cribbs JT, Seo S
PloS one 2021;16(5):e0246358
PloS one 2021;16(5):e0246358
Primary Cilia Mediate TSH-Regulated Thyroglobulin Endocytic Pathways.
Lee J, Sul HJ, Kim KH, Chang JY, Shong M
Frontiers in endocrinology 2021;12:700083
Frontiers in endocrinology 2021;12:700083
Quantitative lineage analysis identifies a hepato-pancreato-biliary progenitor niche.
Willnow D, Benary U, Margineanu A, Vignola ML, Konrath F, Pongrac IM, Karimaddini Z, Vigilante A, Wolf J, Spagnoli FM
Nature 2021 Sep;597(7874):87-91
Nature 2021 Sep;597(7874):87-91
The type 3 adenylyl cyclase is crucial for intestinal mucosal neural network in the gut lamina propria.
Zhou K, Zhou Y, Yang D, Chen T, Liu X, Li S, Wang Z
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2021 Sep;33(9):e14140
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2021 Sep;33(9):e14140
Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome in Experimental Endotoxemia.
Okamoto H, Muraki I, Okada H, Tomita H, Suzuki K, Takada C, Wakayama Y, Kuroda A, Fukuda H, Kawasaki Y, Nishio A, Matsuo M, Tamaoki Y, Inagawa R, Takashima S, Taniguchi T, Suzuki A, Suzuki K, Miyazaki N, Kakino Y, Yasuda R, Fukuta T, Kitagawa Y, Miyake T, Doi T, Yoshida T, Yoshida S, Ogura S
The American journal of pathology 2021 Sep;191(9):1526-1536
The American journal of pathology 2021 Sep;191(9):1526-1536
Cilium induction triggers differentiation of glioma stem cells.
Goranci-Buzhala G, Mariappan A, Ricci-Vitiani L, Josipovic N, Pacioni S, Gottardo M, Ptok J, Schaal H, Callaini G, Rajalingam K, Dynlacht B, Hadian K, Papantonis A, Pallini R, Gopalakrishnan J
Cell reports 2021 Sep 7;36(10):109656
Cell reports 2021 Sep 7;36(10):109656
2-IPMA Ameliorates PM2.5-Induced Inflammation by Promoting Primary Ciliogenesis in RPE Cells.
Choi JY, Bae JE, Kim JB, Jo DS, Park NY, Kim YH, Lee HJ, Kim SH, Kim SH, Jeon HB, Na HW, Choi H, Ryu HY, Ryoo ZY, Lee HS, Cho DH
Molecules (Basel, Switzerland) 2021 Sep 6;26(17)
Molecules (Basel, Switzerland) 2021 Sep 6;26(17)
A ciliopathy complex builds distal appendages to initiate ciliogenesis.
Kumar D, Rains A, Herranz-Pérez V, Lu Q, Shi X, Swaney DL, Stevenson E, Krogan NJ, Huang B, Westlake C, Garcia-Verdugo JM, Yoder BK, Reiter JF
The Journal of cell biology 2021 Sep 6;220(9)
The Journal of cell biology 2021 Sep 6;220(9)
MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis.
Pietrobono S, Franci L, Imperatore F, Zanini C, Stecca B, Chiariello M
Cancers 2021 Sep 29;13(19)
Cancers 2021 Sep 29;13(19)
Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles.
Volz AK, Frei A, Kretschmer V, de Jesus Domingues AM, Ketting RF, Ueffing M, Boldt K, Krämer-Albers EM, May-Simera HL
Nature communications 2021 Sep 27;12(1):5671
Nature communications 2021 Sep 27;12(1):5671
Elucidation of Distinct Modular Assemblies of Smoothened Receptor by Bitopic Ligand Measurement.
Zhao F, Wu Y, Zhou F, Xue D, Zhao S, Lu W, Liu X, Hu T, Qiu Y, Li R, Gu T, Xu Y, Xu F, Zhong G, Jiang Z, Zhao S, Tao H
Journal of medicinal chemistry 2021 Sep 23;64(18):13830-13840
Journal of medicinal chemistry 2021 Sep 23;64(18):13830-13840
Identification of disease-relevant modulators of the SHH pathway in the developing brain.
Mecklenburg N, Kowalczyk I, Witte F, Görne J, Laier A, Mamo TM, Gonschior H, Lehmann M, Richter M, Sporbert A, Purfürst B, Hübner N, Hammes A
Development (Cambridge, England) 2021 Sep 1;148(17)
Development (Cambridge, England) 2021 Sep 1;148(17)
Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion.
Han YK, Kim JS, Lee GB, Lim JH, Park KM
Redox biology 2021 Oct;46:102077
Redox biology 2021 Oct;46:102077
DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.
Guo L, Beck T, Fulmer D, Ramos-Ortiz S, Glover J, Wang C, Moore K, Gensemer C, Morningstar J, Moore R, Schott JJ, Le Tourneau T, Koren N, Norris RA
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Oct;250(10):1432-1449
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Oct;250(10):1432-1449
Cep55 regulation of PI3K/Akt signaling is required for neocortical development and ciliogenesis.
Rashidieh B, Shohayeb B, Bain AL, Fortuna PRJ, Sinha D, Burgess A, Mills R, Adams RC, Lopez JA, Blumbergs P, Finnie J, Kalimutho M, Piper M, Hudson JE, Ng DCH, Khanna KK
PLoS genetics 2021 Oct;17(10):e1009334
PLoS genetics 2021 Oct;17(10):e1009334
Human brain organoids assemble functionally integrated bilateral optic vesicles.
Gabriel E, Albanna W, Pasquini G, Ramani A, Josipovic N, Mariappan A, Schinzel F, Karch CM, Bao G, Gottardo M, Suren AA, Hescheler J, Nagel-Wolfrum K, Persico V, Rizzoli SO, Altmüller J, Riparbelli MG, Callaini G, Goureau O, Papantonis A, Busskamp V, Schneider T, Gopalakrishnan J
Cell stem cell 2021 Oct 7;28(10):1740-1757.e8
Cell stem cell 2021 Oct 7;28(10):1740-1757.e8
Induction of inverted morphology in brain organoids by vertical-mixing bioreactors.
Suong DNA, Imamura K, Inoue I, Kabai R, Sakamoto S, Okumura T, Kato Y, Kondo T, Yada Y, Klein WL, Watanabe A, Inoue H
Communications biology 2021 Oct 22;4(1):1213
Communications biology 2021 Oct 22;4(1):1213
Ciliary Hedgehog signaling regulates cell survival to build the facial midline.
Abrams SR, Reiter JF
eLife 2021 Oct 21;10
eLife 2021 Oct 21;10
Primary Ciliogenesis by 2-Isopropylmalic Acid Prevents PM2.5-Induced Inflammatory Response and MMP-1 Activation in Human Dermal Fibroblasts and a 3-D-Skin Model.
Bae JE, Min D, Choi JY, Choi H, Kim JB, Park NY, Jo DS, Kim YH, Na HW, Kim YJ, Kim ES, Kim HJ, Cho DH
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
Δ9-Tetrahydrocannabinol inhibits Hedgehog-dependent patterning during development.
Lo HF, Hong M, Szutorisz H, Hurd YL, Krauss RS
Development (Cambridge, England) 2021 Oct 1;148(19)
Development (Cambridge, England) 2021 Oct 1;148(19)
Gene replacement therapy restores RCBTB1 expression and cilium length in patient-derived retinal pigment epithelium.
Huang Z, Zhang D, Chen SC, Jennings L, Carvalho LS, Fletcher S, Chen FK, McLenachan S
Journal of cellular and molecular medicine 2021 Nov;25(21):10020-10027
Journal of cellular and molecular medicine 2021 Nov;25(21):10020-10027
Vangl2 participates in the primary ciliary assembly under low fluid shear stress in hUVECs.
Sheng X, Gao S, Sheng Y, Xie X, Wang J, He Y
Cell and tissue research 2021 Nov 5;
Cell and tissue research 2021 Nov 5;
Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity.
Kyrousi C, O'Neill AC, Brazovskaja A, He Z, Kielkowski P, Coquand L, Di Giaimo R, D' Andrea P, Belka A, Forero Echeverry A, Mei D, Lenge M, Cruceanu C, Buchsbaum IY, Khattak S, Fabien G, Binder E, Elmslie F, Guerrini R, Baffet AD, Sieber SA, Treutlein B, Robertson SP, Cappello S
Nature communications 2021 Nov 2;12(1):6298
Nature communications 2021 Nov 2;12(1):6298
Ciliary Type III Adenylyl Cyclase in the VMH Is Crucial for High-Fat Diet-Induced Obesity Mediated by Autophagy.
Yang D, Wu X, Wang W, Zhou Y, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov 16;:e2102568
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov 16;:e2102568
Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly.
Wang L, Paudyal SC, Kang Y, Owa M, Liang FX, Spektor A, Knaut H, Sánchez I, Dynlacht BD
Cell research 2021 Nov 15;
Cell research 2021 Nov 15;
Hydrogen sulfide, a gaseous signaling molecule, elongates primary cilia on kidney tubular epithelial cells by activating extracellular signal-regulated kinase.
Han SJ, Kim JI, Lipschutz JH, Park KM
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Nov 1;25(6):593-601
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Nov 1;25(6):593-601
Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function.
Cullen CL, O'Rourke M, Beasley SJ, Auderset L, Zhen Y, Pepper RE, Gasperini R, Young KM
Glia 2021 May;69(5):1184-1203
Glia 2021 May;69(5):1184-1203
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Dhekne HS, Yanatori I, Vides EG, Sobu Y, Diez F, Tonelli F, Pfeffer SR
Life science alliance 2021 May;4(5)
Life science alliance 2021 May;4(5)
Deletion of Sox9 in the liver leads to hepatic cystogenesis in mice by transcriptionally downregulating Sec63.
Xu WP, Cui YL, Chen LL, Ding K, Ding CH, Chen F, Zhang X, Xie WF
The Journal of pathology 2021 May;254(1):57-69
The Journal of pathology 2021 May;254(1):57-69
De novo purine biosynthesis is a major driver of chemoresistance in glioblastoma.
Shireman JM, Atashi F, Lee G, Ali ES, Saathoff MR, Park CH, Savchuk S, Baisiwala S, Miska J, Lesniak MS, James CD, Stupp R, Kumthekar P, Horbinski CM, Ben-Sahra I, Ahmed AU
Brain : a journal of neurology 2021 May 7;144(4):1230-1246
Brain : a journal of neurology 2021 May 7;144(4):1230-1246
Time-resolved proteomics profiling of the ciliary Hedgehog response.
May EA, Kalocsay M, D'Auriac IG, Schuster PS, Gygi SP, Nachury MV, Mick DU
The Journal of cell biology 2021 May 3;220(5)
The Journal of cell biology 2021 May 3;220(5)
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.
Senatore E, Chiuso F, Rinaldi L, Intartaglia D, Delle Donne R, Pedone E, Catalanotti B, Pirone L, Fiorillo B, Moraca F, Giamundo G, Scala G, Raffeiner A, Torres-Quesada O, Stefan E, Kwiatkowski M, van Pijkeren A, Morleo M, Franco B, Garbi C, Conte I, Feliciello A
The EMBO journal 2021 May 17;40(10):e106503
The EMBO journal 2021 May 17;40(10):e106503
Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis.
Yamakawa D, Katoh D, Kasahara K, Shiromizu T, Matsuyama M, Matsuda C, Maeno Y, Watanabe M, Nishimura Y, Inagaki M
Cell reports 2021 Mar 9;34(10):108817
Cell reports 2021 Mar 9;34(10):108817
CiliaQ: a simple, open-source software for automated quantification of ciliary morphology and fluorescence in 2D, 3D, and 4D images.
Hansen JN, Rassmann S, Stüven B, Jurisch-Yaksi N, Wachten D
The European physical journal. E, Soft matter 2021 Mar 8;44(2):18
The European physical journal. E, Soft matter 2021 Mar 8;44(2):18
Investigating Primary Cilia during Peripheral Nervous System Formation.
Yusifov E, Dumoulin A, Stoeckli ET
International journal of molecular sciences 2021 Mar 20;22(6)
International journal of molecular sciences 2021 Mar 20;22(6)
Identification of a potent antagonist of smoothened in hedgehog signaling.
Fan J, Li H, Kuang L, Zhao Z, He W, Liu C, Wang Y, Cheng SY, Chen W
Cell & bioscience 2021 Mar 2;11(1):46
Cell & bioscience 2021 Mar 2;11(1):46
Sub-toxic levels of cobalt ions impair chondrocyte mechanostranduction via HDAC6-dependent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Liu S, Fu S
Biochemical and biophysical research communications 2021 Mar 12;544:38-43
Biochemical and biophysical research communications 2021 Mar 12;544:38-43
Exovesicular-Shh confers Imatinib resistance by upregulating Bcl2 expression in chronic myeloid leukemia with variant chromosomes.
Anusha, Dalal H, Subramanian S, V P S, Gowda DA, H K, Damodar S, Vyas N
Cell death & disease 2021 Mar 11;12(3):259
Cell death & disease 2021 Mar 11;12(3):259
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis.
Kwon OS, Mishra R, Safieddine A, Coleno E, Alasseur Q, Faucourt M, Barbosa I, Bertrand E, Spassky N, Le Hir H
Nature communications 2021 Mar 1;12(1):1351
Nature communications 2021 Mar 1;12(1):1351
Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ.
Chen C, Xu Q, Zhang Y, Davies BA, Huang Y, Katzmann DJ, Harris PC, Hu J, Ling K
Science advances 2021 Jun;7(26)
Science advances 2021 Jun;7(26)
Increase in primary cilia in the epidermis of patients with atopic dermatitis and psoriasis.
Rizaldy D, Toriyama M, Kato H, Fukui R, Fujita F, Nakamura M, Okada F, Morita A, Ishii KJ
Experimental dermatology 2021 Jun;30(6):792-803
Experimental dermatology 2021 Jun;30(6):792-803
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response.
Chen TY, Huang BM, Tang TK, Chao YY, Xiao XY, Lee PR, Yang LY, Wang CY
Cell death and differentiation 2021 Jun;28(6):1865-1879
Cell death and differentiation 2021 Jun;28(6):1865-1879
Ciliogenesis is Not Directly Regulated by LRRK2 Kinase Activity in Neurons.
Kim H, Sim H, Lee JE, Seo MK, Lim J, Bang Y, Nam D, Lee SY, Chung SK, Choi HJ, Park SW, Son I, Kim J, Seol W
Experimental neurobiology 2021 Jun 30;30(3):232-243
Experimental neurobiology 2021 Jun 30;30(3):232-243
Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle.
Waisman A, Norris AM, Elías Costa M, Kopinke D
Scientific reports 2021 Jun 3;11(1):11793
Scientific reports 2021 Jun 3;11(1):11793
Identification of Cilia in Different Mouse Tissues.
Li X, Yang S, Deepak V, Chinipardaz Z, Yang S
Cells 2021 Jun 29;10(7)
Cells 2021 Jun 29;10(7)
Modeling retinitis pigmentosa through patient-derived retinal organoids.
Li YP, Deng WL, Jin ZB
STAR protocols 2021 Jun 18;2(2):100438
STAR protocols 2021 Jun 18;2(2):100438
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.
Piette BL, Alerasool N, Lin ZY, Lacoste J, Lam MHY, Qian WW, Tran S, Larsen B, Campos E, Peng J, Gingras AC, Taipale M
Molecular cell 2021 Jun 17;81(12):2549-2565.e8
Molecular cell 2021 Jun 17;81(12):2549-2565.e8
Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells.
Qatato M, Venugopalan V, Al-Hashimi A, Rehders M, Valentine AD, Hein Z, Dallto U, Springer S, Brix K
Cells 2021 Jun 16;10(6)
Cells 2021 Jun 16;10(6)
TRIM37 prevents formation of condensate-organized ectopic spindle poles to ensure mitotic fidelity.
Meitinger F, Kong D, Ohta M, Desai A, Oegema K, Loncarek J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms.
Speight P, Rozycki M, Venugopal S, Szászi K, Kofler M, Kapus A
iScience 2021 Jul 23;24(7):102739
iScience 2021 Jul 23;24(7):102739
CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.
Gonçalves AB, Hasselbalch SK, Joensen BB, Patzke S, Martens P, Ohlsen SK, Quinodoz M, Nikopoulos K, Suleiman R, Damsø Jeppesen MP, Weiss C, Christensen ST, Rivolta C, Andersen JS, Farinelli P, Pedersen LB
eLife 2021 Jul 14;10
eLife 2021 Jul 14;10
Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK
Current biology : CB 2021 Jul 12;31(13):2895-2905.e7
Current biology : CB 2021 Jul 12;31(13):2895-2905.e7
Rab34 is necessary for early stages of intracellular ciliogenesis.
Stuck MW, Chong WM, Liao JC, Pazour GJ
Current biology : CB 2021 Jul 12;31(13):2887-2894.e4
Current biology : CB 2021 Jul 12;31(13):2887-2894.e4
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
Gopalan J, Omar MH, Roy A, Cruz NM, Falcone J, Jones KN, Forbush KA, Himmelfarb J, Freedman BS, Scott JD
eLife 2021 Jul 12;10
eLife 2021 Jul 12;10
Sequences in the stalk domain regulate auto-inhibition and ciliary tip localization of the immotile kinesin-4 KIF7.
Blasius TL, Yue Y, Prasad R, Liu X, Gennerich A, Verhey KJ
Journal of cell science 2021 Jul 1;134(13)
Journal of cell science 2021 Jul 1;134(13)
TMEM16A/ANO1 calcium-activated chloride channel as a novel target for the treatment of human respiratory syncytial virus infection.
Pearson H, Todd EJAA, Ahrends M, Hover SE, Whitehouse A, Stacey M, Lippiat JD, Wilkens L, Fieguth HG, Danov O, Hesse C, Barr JN, Mankouri J
Thorax 2021 Jan;76(1):64-72
Thorax 2021 Jan;76(1):64-72
DAB2IP modulates primary cilia formation associated with renal tumorigenesis.
Lin CJ, Dang A, Hernandez E, Hsieh JT
Neoplasia (New York, N.Y.) 2021 Jan;23(1):169-180
Neoplasia (New York, N.Y.) 2021 Jan;23(1):169-180
Nonredundant roles of DIAPHs in primary ciliogenesis.
Palander O, Lam A, Collins RF, Moraes TJ, Trimble WS
The Journal of biological chemistry 2021 Jan-Jun;296:100680
The Journal of biological chemistry 2021 Jan-Jun;296:100680
BBS Proteins Affect Ciliogenesis and Are Essential for Hedgehog Signaling, but Not for Formation of iPSC-Derived RPE-65 Expressing RPE-Like Cells.
Hey CAB, Larsen LJ, Tümer Z, Brøndum-Nielsen K, Grønskov K, Hjortshøj TD, Møller LB
International journal of molecular sciences 2021 Jan 29;22(3)
International journal of molecular sciences 2021 Jan 29;22(3)
LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis.
Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY
Nature communications 2021 Jan 28;12(1):662
Nature communications 2021 Jan 28;12(1):662
Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
Partscht P, Uddin B, Schiebel E
Journal of cell science 2021 Jan 27;134(2)
Journal of cell science 2021 Jan 27;134(2)
Application of green tea catechins, polysaccharides, and flavonol prevent fine dust induced bronchial damage by modulating inflammation and airway cilia.
Kim J, Choi H, Choi DH, Park K, Kim HJ, Park M
Scientific reports 2021 Jan 26;11(1):2232
Scientific reports 2021 Jan 26;11(1):2232
Interaction of INPP5E with ARL13B is essential for its ciliary membrane retention but dispensable for its ciliary entry.
Qiu H, Fujisawa S, Nozaki S, Katoh Y, Nakayama K
Biology open 2021 Jan 25;10(1)
Biology open 2021 Jan 25;10(1)
EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis.
Partisani M, Baron CL, Ghossoub R, Fayad R, Pagnotta S, Abélanet S, Macia E, Brau F, Lacas-Gervais S, Benmerah A, Luton F, Franco M
Journal of cell science 2021 Jan 22;134(2)
Journal of cell science 2021 Jan 22;134(2)
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import.
Kobayashi T, Ishida Y, Hirano T, Katoh Y, Nakayama K
Molecular biology of the cell 2021 Jan 1;32(1):45-56
Molecular biology of the cell 2021 Jan 1;32(1):45-56
Phosphosite T674A mutation in kinesin family member 3A fails to reproduce tissue and ciliary defects characteristic of CILK1 loss of function.
Gailey CD, Wang EJ, Jin L, Ahmadi S, Brautigan DL, Li X, Xu W, Scott MM, Fu Z
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
Developmental dynamics : an official publication of the American Association of Anatomists 2021 Feb;250(2):263-273
Functional inhibition of fatty acid binding protein 4 ameliorates impaired ciliogenesis in GCs.
Jung Y, Cho SM, Kim S, Cheong JH, Kwon HJ
Biochemical and biophysical research communications 2021 Feb 5;539:28-33
Biochemical and biophysical research communications 2021 Feb 5;539:28-33
Loss of primary cilia promotes mitochondria-dependent apoptosis in thyroid cancer.
Lee J, Park KC, Sul HJ, Hong HJ, Kim KH, Kero J, Shong M
Scientific reports 2021 Feb 18;11(1):4181
Scientific reports 2021 Feb 18;11(1):4181
Expression of α-Tubulin Acetyltransferase 1 and Tubulin Acetylation as Selective Forces in Cell Competition.
Rahimi AM, Cai M, Kılıҫ I, Kazerouni ZB, Tapia Contreras C, Hoyer-Fender S
Cells 2021 Feb 14;10(2)
Cells 2021 Feb 14;10(2)
CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.
Zhang YC, Bai YF, Yuan JF, Shen XL, Xu YL, Jian XX, Li S, Song ZQ, Hu HB, Li PY, Tu HQ, Han QY, Wang N, Li AL, Zhang XM, Wu M, Zhou T, Li HY
The Journal of cell biology 2021 Feb 1;220(2)
The Journal of cell biology 2021 Feb 1;220(2)
YAP/TAZ maintain the proliferative capacity and structural organization of radial glial cells during brain development.
Lavado A, Gangwar R, Paré J, Wan S, Fan Y, Cao X
Developmental biology 2021 Dec;480:39-49
Developmental biology 2021 Dec;480:39-49
The 3-beta-hydroxysteroid-Delta(8), Delta(7)-isomerase EBP inhibits cholesterylation of Smoothened.
Qiu ZP, Hu A, Song BL
Biochimica et biophysica acta. Molecular and cell biology of lipids 2021 Dec;1866(12):159041
Biochimica et biophysica acta. Molecular and cell biology of lipids 2021 Dec;1866(12):159041
Cisplatin induces lung cell cilia disruption and lung damage via oxidative stress.
Han YK, Kim JS, Jang G, Park KM
Free radical biology & medicine 2021 Dec;177:270-277
Free radical biology & medicine 2021 Dec;177:270-277
Exocyst complex mediates recycling of internal cilia.
Rivera-Molina FE, Xi Z, Reales E, Wang B, Toomre D
Current biology : CB 2021 Dec 20;31(24):5580-5589.e5
Current biology : CB 2021 Dec 20;31(24):5580-5589.e5
Biallelic deep intronic variant c.5457+81T>A in TRIP11 causes loss of function and results in achondrogenesis 1A.
Upadhyai P, Radhakrishnan P, Guleria VS, Kausthubham N, Nayak SS, Superti-Furga A, Girisha KM
Human mutation 2021 Aug;42(8):1005-1014
Human mutation 2021 Aug;42(8):1005-1014
Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.
Shinmura K, Kusafuka K, Kawasaki H, Kato H, Hariyama T, Tsuchiya K, Kawanishi Y, Funai K, Misawa K, Mineta H, Sugimura H
The Journal of pathology 2021 Aug;254(5):519-530
The Journal of pathology 2021 Aug;254(5):519-530
Differential Roles of Tubby Family Proteins in Ciliary Formation and Trafficking.
Hong JJ, Kim KE, Park SY, Bok J, Seo JT, Moon SJ
Molecules and cells 2021 Aug 31;44(8):591-601
Molecules and cells 2021 Aug 31;44(8):591-601
Impaired Ciliary Beat Frequency and Ciliogenesis Alteration during Airway Epithelial Cell Differentiation in COPD.
Ancel J, Belgacemi R, Diabasana Z, Perotin JM, Bonnomet A, Dewolf M, Launois C, Mulette P, Deslée G, Polette M, Dormoy V
Diagnostics (Basel, Switzerland) 2021 Aug 31;11(9)
Diagnostics (Basel, Switzerland) 2021 Aug 31;11(9)
FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.
Zhang Y, Hao J, Tarrago MG, Warner GM, Giorgadze N, Wei Q, Huang Y, He K, Chen C, Peclat TR, White TA, Ling K, Tchkonia T, Kirkland JL, Chini EN, Hu J
Cell reports 2021 Aug 3;36(5):109481
Cell reports 2021 Aug 3;36(5):109481
Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.
Cyge B, Voronina V, Hoque M, Kim EN, Hall J, Bailey-Lundberg JM, Pazour GJ, Crawford HC, Moon RT, Li FQ, Takemaru KI
Scientific reports 2021 Aug 26;11(1):17220
Scientific reports 2021 Aug 26;11(1):17220
A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts.
Grosch M, Brunner K, Ilyaskin AV, Schober M, Staudner T, Schmied D, Stumpp T, Schmidt KN, Madej MG, Pessoa TD, Othmen H, Kubitza M, Osten L, de Vries U, Mair MM, Somlo S, Moser M, Kunzelmann K, Ziegler C, Haerteis S, Korbmacher C, Witzgall R
Journal of cell science 2021 Aug 15;134(16)
Journal of cell science 2021 Aug 15;134(16)
Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress.
Mustafa R, Rawas C, Mannal N, Kreiner G, Spittau B, Kamińska K, Yilmaz R, Pötschke C, Kirsch J, Liss B, Tucker KL, Parlato R
Antioxidants (Basel, Switzerland) 2021 Aug 13;10(8)
Antioxidants (Basel, Switzerland) 2021 Aug 13;10(8)
Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.
Hor CHH, Lo JCW, Cham ALS, Leong WY, Goh ELK
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 11;41(32):6850-6863
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021 Aug 11;41(32):6850-6863
Xpo7 negatively regulates Hedgehog signaling by exporting Gli2 from the nucleus.
Markiewicz Ł, Uśpieński T, Baran B, Niedziółka SM, Niewiadomski P
Cellular signalling 2021 Apr;80:109907
Cellular signalling 2021 Apr;80:109907
A CRISPR and high-content imaging assay compliant with ACMG/AMP guidelines for clinical variant interpretation in ciliopathies.
Nazlamova L, Thomas NS, Cheung MK, Legebeke J, Lord J, Pengelly RJ, Tapper WJ, Wheway G
Human genetics 2021 Apr;140(4):593-607
Human genetics 2021 Apr;140(4):593-607
A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities.
Bentley-Ford MR, Engle SE, Clearman KR, Haycraft CJ, Andersen RS, Croyle MJ, Rains AB, Berbari NF, Yoder BK
Human molecular genetics 2021 Apr 26;30(3-4):234-246
Human molecular genetics 2021 Apr 26;30(3-4):234-246
WDR35 is involved in subcellular localization of acetylated tubulin in 293T cells.
Sekiguchi T, Ishii T, Kobayashi H, Furuno N
Biochemical and biophysical research communications 2021 Apr 2;547:169-175
Biochemical and biophysical research communications 2021 Apr 2;547:169-175
The N-terminal Leu-Pro-Gln sequence of Rab34 is required for ciliogenesis in hTERT-RPE1 cells.
Oguchi ME, Homma Y, Fukuda M
Small GTPases 2021 Apr 16;:1-7
Small GTPases 2021 Apr 16;:1-7
Roles for ELMOD2 and Rootletin in ciliogenesis.
Turn RE, Linnert J, Gigante ED, Wolfrum U, Caspary T, Kahn RA
Molecular biology of the cell 2021 Apr 15;32(8):800-822
Molecular biology of the cell 2021 Apr 15;32(8):800-822
Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone.
Wiegering A, Dildrop R, Vesque C, Khanna H, Schneider-Maunoury S, Gerhardt C
Molecular biology of the cell 2021 Apr 15;32(8):675-689
Molecular biology of the cell 2021 Apr 15;32(8):675-689
A ZFYVE19 gene mutation associated with neonatal cholestasis and cilia dysfunction: case report with a novel pathogenic variant.
Mandato C, Siano MA, Nazzaro L, Gelzo M, Francalanci P, Rizzo F, D'Agostino Y, Morleo M, Brillante S, Weisz A, Franco B, Vajro P
Orphanet journal of rare diseases 2021 Apr 14;16(1):179
Orphanet journal of rare diseases 2021 Apr 14;16(1):179
HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells.
Shi P, Hoang-Minh LB, Tian J, Cheng A, Basrai R, Kalaria N, Lebowitz JJ, Khoshbouei H, Deleyrolle LP, Sarkisian MR
Cancers 2021 Apr 1;13(7)
Cancers 2021 Apr 1;13(7)
Characterization of primary cilia features reveal cell-type specific variability in in vitro models of osteogenic and chondrogenic differentiation.
Upadhyai P, Guleria VS, Udupa P
PeerJ 2020;8:e9799
PeerJ 2020;8:e9799
FOP Negatively Regulates Ciliogenesis and Promotes Cell Cycle Re-entry by Facilitating Primary Cilia Disassembly.
Jiang H, Liu S, Cheung MH, Amin A, Liang C
Frontiers in cell and developmental biology 2020;8:590449
Frontiers in cell and developmental biology 2020;8:590449
Effect of Cell Spreading on Rosette Formation by Human Pluripotent Stem Cell-Derived Neural Progenitor Cells.
Townshend RF, Shao Y, Wang S, Cortez CL, Esfahani SN, Spence JR, O'Shea KS, Fu J, Gumucio DL, Taniguchi K
Frontiers in cell and developmental biology 2020;8:588941
Frontiers in cell and developmental biology 2020;8:588941
CEP164 Deficiency Causes Hyperproliferation of Pancreatic Cancer Cells.
Kobayashi T, Tanaka K, Mashima Y, Shoda A, Tokuda M, Itoh H
Frontiers in cell and developmental biology 2020;8:587691
Frontiers in cell and developmental biology 2020;8:587691
Distinct Roles of TRAPPC8 and TRAPPC12 in Ciliogenesis via Their Interactions With OFD1.
Zhang C, Li C, Siu GKY, Luo X, Yu S
Frontiers in cell and developmental biology 2020;8:148
Frontiers in cell and developmental biology 2020;8:148
Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa.
Gao ML, Lei XL, Han F, He KW, Jin SQ, Zhang YY, Jin ZB
Frontiers in cell and developmental biology 2020;8:128
Frontiers in cell and developmental biology 2020;8:128
Analysis of Caveolin in Primary Cilia.
Morthorst SK, Mogensen JB, Christensen ST, Pedersen LB
Methods in molecular biology (Clifton, N.J.) 2020;2169:27-41
Methods in molecular biology (Clifton, N.J.) 2020;2169:27-41
A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells.
Dias JM, Alekseenko Z, Jeggari A, Boareto M, Vollmer J, Kozhevnikova M, Wang H, Matise MP, Alexeyenko A, Iber D, Ericson J
Science advances 2020 Sep;6(38)
Science advances 2020 Sep;6(38)
Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.
Gerakopoulos V, Ngo P, Tsiokas L
Life science alliance 2020 Sep;3(9)
Life science alliance 2020 Sep;3(9)
Loss of Cilia Does Not Slow Liver Disease Progression in Mouse Models of Autosomal Recessive Polycystic Kidney Disease.
Gallagher AR, Somlo S
Kidney360 2020 Sep 24;1(9):962-968
Kidney360 2020 Sep 24;1(9):962-968
Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2.
Tona Y, Wu DK
eLife 2020 Sep 23;9
eLife 2020 Sep 23;9
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.
Cowan CS, Renner M, De Gennaro M, Gross-Scherf B, Goldblum D, Hou Y, Munz M, Rodrigues TM, Krol J, Szikra T, Cuttat R, Waldt A, Papasaikas P, Diggelmann R, Patino-Alvarez CP, Galliker P, Spirig SE, Pavlinic D, Gerber-Hollbach N, Schuierer S, Srdanovic A, Balogh M, Panero R, Kusnyerik A, Szabo A, Stadler MB, Orgül S, Picelli S, Hasler PW, Hierlemann A, Scholl HPN, Roma G, Nigsch F, Roska B
Cell 2020 Sep 17;182(6):1623-1640.e34
Cell 2020 Sep 17;182(6):1623-1640.e34
Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development.
Terry TT, Cheng T, Mahjoub M, Zong H
Developmental biology 2020 Sep 15;465(2):130-143
Developmental biology 2020 Sep 15;465(2):130-143
Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.
Archambault D, Cheong A, Iverson E, Tremblay KD, Mager J
Developmental biology 2020 Sep 1;465(1):1-10
Developmental biology 2020 Sep 1;465(1):1-10
Primary cilia mediate parathyroid hormone receptor type 1 osteogenic actions in osteocytes and osteoblasts via Gli activation.
Martín-Guerrero E, Tirado-Cabrera I, Buendía I, Alonso V, Gortázar AR, Ardura JA
Journal of cellular physiology 2020 Oct;235(10):7356-7369
Journal of cellular physiology 2020 Oct;235(10):7356-7369
Mutations in the exocyst component EXOC2 cause severe defects in human brain development.
Van Bergen NJ, Ahmed SM, Collins F, Cowley M, Vetro A, Dale RC, Hock DH, de Caestecker C, Menezes M, Massey S, Ho G, Pisano T, Glover S, Gusman J, Stroud DA, Dinger M, Guerrini R, Macara IG, Christodoulou J
The Journal of experimental medicine 2020 Oct 5;217(10)
The Journal of experimental medicine 2020 Oct 5;217(10)
A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.
Abdelhamed Z, Lukacs M, Cindric S, Ali S, Omran H, Stottmann RW
Disease models & mechanisms 2020 Oct 30;13(10)
Disease models & mechanisms 2020 Oct 30;13(10)
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia.
Nguyen QPH, Liu Z, Albulescu A, Ouyang H, Zlock L, Coyaud E, Laurent E, Finkbeiner W, Moraes TJ, Raught B, Mennella V
Developmental cell 2020 Oct 26;55(2):209-223.e7
Developmental cell 2020 Oct 26;55(2):209-223.e7
Roles of TOG and jelly-roll domains of centrosomal protein CEP104 in its functions in cilium elongation and Hedgehog signaling.
Yamazoe T, Nagai T, Umeda S, Sugaya Y, Mizuno K
The Journal of biological chemistry 2020 Oct 23;295(43):14723-14736
The Journal of biological chemistry 2020 Oct 23;295(43):14723-14736
Use of patient derived urine renal epithelial cells to confirm pathogenicity of PKHD1 alleles.
Molinari E, Srivastava S, Dewhurst RM, Sayer JA
BMC nephrology 2020 Oct 15;21(1):435
BMC nephrology 2020 Oct 15;21(1):435
Differentiation of ciliated human midbrain-derived LUHMES neurons.
Lauter G, Coschiera A, Yoshihara M, Sugiaman-Trapman D, Ezer S, Sethurathinam S, Katayama S, Kere J, Swoboda P
Journal of cell science 2020 Nov 9;133(21)
Journal of cell science 2020 Nov 9;133(21)
Centrosome and ciliary abnormalities in fetal akinesia deformation sequence human fibroblasts.
Jühlen R, Martinelli V, Vinci C, Breckpot J, Fahrenkrog B
Scientific reports 2020 Nov 9;10(1):19301
Scientific reports 2020 Nov 9;10(1):19301
Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling.
Bosakova M, Abraham SP, Nita A, Hruba E, Buchtova M, Taylor SP, Duran I, Martin J, Svozilova K, Barta T, Varecha M, Balek L, Kohoutek J, Radaszkiewicz T, Pusapati GV, Bryja V, Rush ET, Thiffault I, Nickerson DA, Bamshad MJ, University of Washington Center for Mendelian Genomics., Rohatgi R, Cohn DH, Krakow D, Krejci P
EMBO molecular medicine 2020 Nov 6;12(11):e11739
EMBO molecular medicine 2020 Nov 6;12(11):e11739
LRP2 controls sonic hedgehog-dependent differentiation of cardiac progenitor cells during outflow tract formation.
Christ A, Marczenke M, Willnow TE
Human molecular genetics 2020 Nov 25;29(19):3183-3196
Human molecular genetics 2020 Nov 25;29(19):3183-3196
Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus.
Lee CH, Song DK, Park CB, Choi J, Kang GM, Shin SH, Kwon I, Park S, Kim S, Kim JY, Dugu H, Park JW, Choi JH, Min SH, Sohn JW, Kim MS
Nature communications 2020 Nov 13;11(1):5772
Nature communications 2020 Nov 13;11(1):5772
Primary cilium remodeling mediates a cell signaling switch in differentiating neurons.
Toro-Tapia G, Das RM
Science advances 2020 May;6(21):eabb0601
Science advances 2020 May;6(21):eabb0601
Pannexin-1 mediates fluid shear stress-sensitive purinergic signaling and cyst growth in polycystic kidney disease.
Verschuren EHJ, Rigalli JP, Castenmiller C, Rohrbach MU, Bindels RJM, Peters DJM, Arjona FJ, Hoenderop JGJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6382-6398
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6382-6398
Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis.
Wang W, Allard BA, Pottorf TS, Wang HH, Vivian JL, Tran PV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6369-6381
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):6369-6381
ECE2 regulates neurogenesis and neuronal migration during human cortical development.
Buchsbaum IY, Kielkowski P, Giorgio G, O'Neill AC, Di Giaimo R, Kyrousi C, Khattak S, Sieber SA, Robertson SP, Cappello S
EMBO reports 2020 May 6;21(5):e48204
EMBO reports 2020 May 6;21(5):e48204
TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating.
Yan H, Chen C, Chen H, Hong H, Huang Y, Ling K, Hu J, Wei Q
Nature communications 2020 May 4;11(1):2196
Nature communications 2020 May 4;11(1):2196
Profilin1-Dependent F-Actin Assembly Controls Division of Apical Radial Glia and Neocortex Development.
Kullmann JA, Meyer S, Pipicelli F, Kyrousi C, Schneider F, Bartels N, Cappello S, Rust MB
Cerebral cortex (New York, N.Y. : 1991) 2020 May 18;30(6):3467-3482
Cerebral cortex (New York, N.Y. : 1991) 2020 May 18;30(6):3467-3482
Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3.
Jászai J, Thamm K, Karbanová J, Janich P, Fargeas CA, Huttner WB, Corbeil D
The Journal of biological chemistry 2020 May 1;295(18):6007-6022
The Journal of biological chemistry 2020 May 1;295(18):6007-6022
ARL13B regulates Sonic hedgehog signaling from outside primary cilia.
Gigante ED, Taylor MR, Ivanova AA, Kahn RA, Caspary T
eLife 2020 Mar 4;9
eLife 2020 Mar 4;9
Conditional switching of KIF2A mutation provides new insights into cortical malformation pathogeny.
Gilet JG, Ivanova EL, Trofimova D, Rudolf G, Meziane H, Broix L, Drouot N, Courraud J, Skory V, Voulleminot P, Osipenko M, Bahi-Buisson N, Yalcin B, Birling MC, Hinckelmann MV, Kwok BH, Allingham JS, Chelly J
Human molecular genetics 2020 Mar 27;29(5):766-784
Human molecular genetics 2020 Mar 27;29(5):766-784
Nek2 kinase displaces distal appendages from the mother centriole prior to mitosis.
Viol L, Hata S, Pastor-Peidro A, Neuner A, Murke F, Wuchter P, Ho AD, Giebel B, Pereira G
The Journal of cell biology 2020 Mar 2;219(3)
The Journal of cell biology 2020 Mar 2;219(3)
Functional Alterations in Ciliogenesis-Associated Kinase 1 (CILK1) that Result from Mutations Linked to Juvenile Myoclonic Epilepsy.
Wang EJ, Gailey CD, Brautigan DL, Fu Z
Cells 2020 Mar 12;9(3)
Cells 2020 Mar 12;9(3)
Primary cilia mediate Klf2-dependant Notch activation in regenerating heart.
Li X, Lu Q, Peng Y, Geng F, Shao X, Zhou H, Cao Y, Zhang R
Protein & cell 2020 Jun;11(6):433-445
Protein & cell 2020 Jun;11(6):433-445
A novel CDK-independent function of p27Kip1 in preciliary vesicle trafficking during ciliogenesis.
Yukimoto H, Miyamoto T, Kiyono T, Wang S, Matsuura S, Mizoguchi A, Katayama N, Inagaki M, Kasahara K
Biochemical and biophysical research communications 2020 Jun 30;527(3):716-722
Biochemical and biophysical research communications 2020 Jun 30;527(3):716-722
Epb41l5 interacts with Iqcb1 and regulates ciliary function in zebrafish embryos.
Yu T, Matsuda M
Journal of cell science 2020 Jun 28;133(12)
Journal of cell science 2020 Jun 28;133(12)
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.
Hansen JN, Kaiser F, Klausen C, Stüven B, Chong R, Bönigk W, Mick DU, Möglich A, Jurisch-Yaksi N, Schmidt FI, Wachten D
eLife 2020 Jun 24;9
eLife 2020 Jun 24;9
Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly.
Lin YN, Lee YS, Li SK, Tang TK
Journal of cell science 2020 Jun 24;133(12)
Journal of cell science 2020 Jun 24;133(12)
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division.
Bonucci M, Kuperwasser N, Barbe S, Koka V, de Villeneuve D, Zhang C, Srivastava N, Jia X, Stokes MP, Bienaimé F, Verkarre V, Lopez JB, Jaulin F, Pontoglio M, Terzi F, Delaval B, Piel M, Pende M
Nature communications 2020 Jun 24;11(1):3200
Nature communications 2020 Jun 24;11(1):3200
CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.
Ochi T, Quarantotti V, Lin H, Jullien J, Rosa E Silva I, Boselli F, Barnabas DD, Johnson CM, McLaughlin SH, Freund SMV, Blackford AN, Kimata Y, Goldstein RE, Jackson SP, Blundell TL, Dutcher SK, Gergely F, van Breugel M
Structure (London, England : 1993) 2020 Jun 2;28(6):674-689.e11
Structure (London, England : 1993) 2020 Jun 2;28(6):674-689.e11
Insufficiency of ciliary cholesterol in hereditary Zellweger syndrome.
Miyamoto T, Hosoba K, Itabashi T, Iwane AH, Akutsu SN, Ochiai H, Saito Y, Yamamoto T, Matsuura S
The EMBO journal 2020 Jun 17;39(12):e103499
The EMBO journal 2020 Jun 17;39(12):e103499
Robust classification of cell cycle phase and biological feature extraction by image-based deep learning.
Nagao Y, Sakamoto M, Chinen T, Okada Y, Takao D
Molecular biology of the cell 2020 Jun 15;31(13):1346-1354
Molecular biology of the cell 2020 Jun 15;31(13):1346-1354
Intracellular calcium response of primary cilia of tubular cells to modulated shear stress under oxidative stress.
Chikamori M, Kimura H, Inagi R, Zhou J, Nangaku M, Fujii T
Biomicrofluidics 2020 Jul;14(4):044102
Biomicrofluidics 2020 Jul;14(4):044102
Ciliary proteins specify the cell inflammatory response by tuning NFκB signalling, independently of primary cilia.
Mc Fie M, Koneva L, Collins I, Coveney CR, Clube AM, Chanalaris A, Vincent TL, Bezbradica JS, Sansom SN, Wann AKT
Journal of cell science 2020 Jul 8;133(13)
Journal of cell science 2020 Jul 8;133(13)
Ubiquitin links smoothened to intraflagellar transport to regulate Hedgehog signaling.
Desai PB, Stuck MW, Lv B, Pazour GJ
The Journal of cell biology 2020 Jul 6;219(7)
The Journal of cell biology 2020 Jul 6;219(7)
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.
Bangs FK, Miller P, O'Neill E
Disease models & mechanisms 2020 Jul 30;13(7)
Disease models & mechanisms 2020 Jul 30;13(7)
Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals.
Findakly S, Choudhury A, Daggubati V, Pekmezci M, Lang UE, Raleigh DR
Acta neuropathologica communications 2020 Jul 20;8(1):114
Acta neuropathologica communications 2020 Jul 20;8(1):114
Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control.
Ho EK, Tsai AE, Stearns T
Current biology : CB 2020 Jul 20;30(14):2829-2835.e5
Current biology : CB 2020 Jul 20;30(14):2829-2835.e5
Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.
Fulmer D, Toomer KA, Glover J, Guo L, Moore K, Moore R, Stairley R, Gensemer C, Abrol S, Rumph MK, Emetu F, Lipschutz JH, McDowell C, Bian J, Wang C, Beck T, Wessels A, Renault MA, Norris RA
Developmental biology 2020 Jul 1;463(1):26-38
Developmental biology 2020 Jul 1;463(1):26-38
Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD.
Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin JM, Germain A, Lalun N, Birembaut P, Dubernard X, Mérol JC, Delepine G, Polette M, Deslée G, Dormoy V
EBioMedicine 2020 Jan;51:102572
EBioMedicine 2020 Jan;51:102572
Intraflagellar-transport A dysfunction causes hyperphagia-induced systemic insulin resistance in a pre-obese state.
Jacobs DT, Allard BA, Pottorf TS, Silva LM, Wang W, Al-Naamani A, Agborbesong E, Wang T, Carr DA, Tran PV
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):148-160
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):148-160
ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
Jung E, Choi TI, Lee JE, Kim CH, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1331-1344
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1331-1344
CENPV Is a CYLD-Interacting Molecule Regulating Ciliary Acetylated α-Tubulin.
Chiticariu E, Regamey A, Huber M, Hohl D
The Journal of investigative dermatology 2020 Jan;140(1):66-74.e4
The Journal of investigative dermatology 2020 Jan;140(1):66-74.e4
hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning.
Pizon V, Gaudin N, Poteau M, Cifuentes-Diaz C, Demdou R, Heyer V, Reina San Martin B, Azimzadeh J
Biology of the cell 2020 Jan;112(1):22-37
Biology of the cell 2020 Jan;112(1):22-37
The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis.
Li ZZ, Zhao WL, Wang GS, Gu NH, Sun F
Bioscience reports 2020 Jan 31;40(1)
Bioscience reports 2020 Jan 31;40(1)
MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity.
Pottorf TS, Fagan MP, Burkey BF, Cho DJ, Vath JE, Tran PV
JCI insight 2020 Jan 30;5(2)
JCI insight 2020 Jan 30;5(2)
The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development.
Shohayeb B, Ho U, Yeap YY, Parton RG, Millard SS, Xu Z, Piper M, Ng DCH
Human molecular genetics 2020 Jan 15;29(2):248-263
Human molecular genetics 2020 Jan 15;29(2):248-263
PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress.
Boukhalfa A, Nascimbeni AC, Ramel D, Dupont N, Hirsch E, Gayral S, Laffargue M, Codogno P, Morel E
Nature communications 2020 Jan 15;11(1):294
Nature communications 2020 Jan 15;11(1):294
TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
Bowie E, Goetz SC
eLife 2020 Jan 14;9
eLife 2020 Jan 14;9
NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
Liu P, Dodson M, Fang D, Chapman E, Zhang DD
PLoS biology 2020 Feb;18(2):e3000620
PLoS biology 2020 Feb;18(2):e3000620
CEP41-mediated ciliary tubulin glutamylation drives angiogenesis through AURKA-dependent deciliation.
Ki SM, Kim JH, Won SY, Oh SJ, Lee IY, Bae YK, Chung KW, Choi BO, Park B, Choi EJ, Lee JE
EMBO reports 2020 Feb 5;21(2):e48290
EMBO reports 2020 Feb 5;21(2):e48290
Nubp2 is required for cranial neural crest survival in the mouse.
DiStasio A, Paulding D, Chaturvedi P, Stottmann RW
Developmental biology 2020 Feb 15;458(2):189-199
Developmental biology 2020 Feb 15;458(2):189-199
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
Flynn M, Whitton L, Donohoe G, Morrison CG, Morris DW
Human molecular genetics 2020 Feb 1;29(3):407-417
Human molecular genetics 2020 Feb 1;29(3):407-417
DIAPH1 regulates ciliogenesis and trafficking in primary cilia.
Palander O, Trimble WS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16516-16535
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Dec;34(12):16516-16535
Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.
Xing L, Kalebic N, Namba T, Vaid S, Wimberger P, Huttner WB
Neuron 2020 Dec 23;108(6):1113-1129.e6
Neuron 2020 Dec 23;108(6):1113-1129.e6
Gpr37l1/prosaposin receptor regulates Ptch1 trafficking, Shh production, and cell proliferation in cerebellar primary astrocytes.
La Sala G, Di Pietro C, Matteoni R, Bolasco G, Marazziti D, Tocchini-Valentini GP
Journal of neuroscience research 2020 Dec 17;
Journal of neuroscience research 2020 Dec 17;
Sonic hedgehog signalling as a potential endobronchial biomarker in COPD.
Ancel J, Belgacemi R, Perotin JM, Diabasana Z, Dury S, Dewolf M, Bonnomet A, Lalun N, Birembaut P, Polette M, Deslée G, Dormoy V
Respiratory research 2020 Aug 7;21(1):207
Respiratory research 2020 Aug 7;21(1):207
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K
eLife 2020 Aug 6;9
eLife 2020 Aug 6;9
Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling.
Streets AJ, Prosseda PP, Ong AC
JCI insight 2020 Aug 20;5(16)
JCI insight 2020 Aug 20;5(16)
An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics.
Zalenski AA, Majumder S, De K, Venere M
Scientific reports 2020 Aug 18;10(1):13946
Scientific reports 2020 Aug 18;10(1):13946
Primary Ciliary Deficits in the Dentate Gyrus of Fragile X Syndrome.
Lee B, Panda S, Lee HY
Stem cell reports 2020 Aug 11;15(2):454-466
Stem cell reports 2020 Aug 11;15(2):454-466
An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration.
Su S, Begum S, Ezratty EJ
Molecular biology of the cell 2020 Aug 1;31(17):1917-1930
Molecular biology of the cell 2020 Aug 1;31(17):1917-1930
A reduction of primary cilia but not hedgehog signaling disrupts morphogenesis in testicular organoids.
Goldsmith TM, Sakib S, Webster D, Carlson DF, Van der Hoorn F, Dobrinski I
Cell and tissue research 2020 Apr;380(1):191-200
Cell and tissue research 2020 Apr;380(1):191-200
Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration.
Kim Y, Lee J, Seppala M, Cobourne MT, Kim SH
Nature communications 2020 Apr 24;11(1):1994
Nature communications 2020 Apr 24;11(1):1994
The HOPS complex subunit VPS39 controls ciliogenesis through autophagy.
Iaconis D, Crina C, Brillante S, Indrieri A, Morleo M, Franco B
Human molecular genetics 2020 Apr 15;29(6):1018-1029
Human molecular genetics 2020 Apr 15;29(6):1018-1029
The primary cilium dampens proliferative signaling and represses a G2/M transcriptional network in quiescent myoblasts.
Venugopal N, Ghosh A, Gala H, Aloysius A, Vyas N, Dhawan J
BMC molecular and cell biology 2020 Apr 15;21(1):25
BMC molecular and cell biology 2020 Apr 15;21(1):25
Roles for IFT172 and Primary Cilia in Cell Migration, Cell Division, and Neocortex Development.
Pruski M, Hu L, Yang C, Wang Y, Zhang JB, Zhang L, Huang Y, Rajnicek AM, St Clair D, McCaig CD, Lang B, Ding YQ
Frontiers in cell and developmental biology 2019;7:287
Frontiers in cell and developmental biology 2019;7:287
Ocular Ciliopathies: Genetic and Mechanistic Insights into Developing Therapies.
Shivanna M, Anand M, Chakrabarti S, Khanna H
Current medicinal chemistry 2019;26(17):3120-3131
Current medicinal chemistry 2019;26(17):3120-3131
Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish.
Maerz LD, Burkhalter MD, Schilpp C, Wittekindt OH, Frick M, Philipp M
Communications biology 2019;2:31
Communications biology 2019;2:31
Induction of Neural Crest Stem Cells From Bardet-Biedl Syndrome Patient Derived hiPSCs.
Barrell WB, Griffin JN, Harvey JL, HipSci Consortium., Danovi D, Beales P, Grigoriadis AE, Liu KJ
Frontiers in molecular neuroscience 2019;12:139
Frontiers in molecular neuroscience 2019;12:139
661W Photoreceptor Cell Line as a Cell Model for Studying Retinal Ciliopathies.
Wheway G, Nazlamova L, Turner D, Cross S
Frontiers in genetics 2019;10:308
Frontiers in genetics 2019;10:308
Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation.
Fokin Artem I, Zhapparova Olga N, Burakov Anton V, Nadezhdina Elena S
Protoplasma 2019 Sep;256(5):1361-1373
Protoplasma 2019 Sep;256(5):1361-1373
Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening.
Kim M, Mun H, Sung CO, Cho EJ, Jeon HJ, Chun SM, Jung DJ, Shin TH, Jeong GS, Kim DK, Choi EK, Jeong SY, Taylor AM, Jain S, Meyerson M, Jang SJ
Nature communications 2019 Sep 5;10(1):3991
Nature communications 2019 Sep 5;10(1):3991
NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling.
Martin-Hurtado A, Martin-Morales R, Robledinos-Antón N, Blanco R, Palacios-Blanco I, Lastres-Becker I, Cuadrado A, Garcia-Gonzalo FR
Scientific reports 2019 Sep 25;9(1):13896
Scientific reports 2019 Sep 25;9(1):13896
Requirement of IFT-B-BBSome complex interaction in export of GPR161 from cilia.
Nozaki S, Castro Araya RF, Katoh Y, Nakayama K
Biology open 2019 Sep 17;8(9)
Biology open 2019 Sep 17;8(9)
Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.
Mao H, Tang Z, Li H, Sun B, Tan M, Fan S, Zhu Y, Sun Y
Protein & cell 2019 Oct;10(10):726-744
Protein & cell 2019 Oct;10(10):726-744
Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex.
Gerondopoulos A, Strutt H, Stevenson NL, Sobajima T, Levine TP, Stephens DJ, Strutt D, Barr FA
Current biology : CB 2019 Oct 7;29(19):3323-3330.e8
Current biology : CB 2019 Oct 7;29(19):3323-3330.e8
Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.
Conkar D, Bayraktar H, Firat-Karalar EN
Scientific reports 2019 Oct 3;9(1):14250
Scientific reports 2019 Oct 3;9(1):14250
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.
Khouj EM, Prosser SL, Tada H, Chong WM, Liao JC, Sugasawa K, Morrison CG
Journal of cell science 2019 Oct 3;132(19)
Journal of cell science 2019 Oct 3;132(19)
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2.
Spiombi E, Angrisani A, Fonte S, De Feudis G, Fabretti F, Cucchi D, Izzo M, Infante P, Miele E, Po A, Di Magno L, Magliozzi R, Guardavaccaro D, Maroder M, Canettieri G, Giannini G, Ferretti E, Gulino A, Di Marcotullio L, Moretti M, De Smaele E
Oncogenesis 2019 Nov 4;8(11):64
Oncogenesis 2019 Nov 4;8(11):64
Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.
Hilgendorf KI, Johnson CT, Mezger A, Rice SL, Norris AM, Demeter J, Greenleaf WJ, Reiter JF, Kopinke D, Jackson PK
Cell 2019 Nov 27;179(6):1289-1305.e21
Cell 2019 Nov 27;179(6):1289-1305.e21
microRNAs Regulating Human and Mouse Naïve Pluripotency.
Wang Y, Hussein AM, Somasundaram L, Sankar R, Detraux D, Mathieu J, Ruohola-Baker H
International journal of molecular sciences 2019 Nov 22;20(23)
International journal of molecular sciences 2019 Nov 22;20(23)
RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
Lara Ordónez AJ, Fernández B, Fdez E, Romo-Lozano M, Madero-Pérez J, Lobbestael E, Baekelandt V, Aiastui A, López de Munaín A, Melrose HL, Civiero L, Hilfiker S
Human molecular genetics 2019 Nov 1;28(21):3552-3568
Human molecular genetics 2019 Nov 1;28(21):3552-3568
A Sexually Dimorphic Role for STAT3 in Sonic Hedgehog Medulloblastoma.
White CL, Jayasekara WSN, Picard D, Chen J, Watkins DN, Cain JE, Remke M, Gough DJ
Cancers 2019 Nov 1;11(11)
Cancers 2019 Nov 1;11(11)
Primary Cilia Exhibit Mechanosensitivity to Cyclic Tensile Strain and Lineage-Dependent Expression in Adipose-Derived Stem Cells.
Bodle J, Hamouda MS, Cai S, Williams RB, Bernacki SH, Loboa EG
Scientific reports 2019 May 29;9(1):8009
Scientific reports 2019 May 29;9(1):8009
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis.
Bhattarai SR, Begum S, Popow R, Ezratty EJ
Development (Cambridge, England) 2019 May 10;146(9)
Development (Cambridge, England) 2019 May 10;146(9)
Endosomal trafficking defects in patient cells with KIAA1109 biallelic variants.
Kane MS, Diamonstein CJ, Hauser N, Deeken JF, Niederhuber JE, Vilboux T
Genes & diseases 2019 Mar;6(1):56-67
Genes & diseases 2019 Mar;6(1):56-67
Indian Hedgehog links obesity to development of hepatocellular carcinoma.
Chong YC, Lim TE, Fu Y, Shin EM, Tergaonkar V, Han W
Oncogene 2019 Mar;38(12):2206-2222
Oncogene 2019 Mar;38(12):2206-2222
Fine particulate matter (PM2.5) inhibits ciliogenesis by increasing SPRR3 expression via c-Jun activation in RPE cells and skin keratinocytes.
Bae JE, Choi H, Shin DW, Na HW, Park NY, Kim JB, Jo DS, Cho MJ, Lyu JH, Chang JH, Lee EH, Lee TR, Kim HJ, Cho DH
Scientific reports 2019 Mar 8;9(1):3994
Scientific reports 2019 Mar 8;9(1):3994
Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase.
Kunova Bosakova M, Nita A, Gregor T, Varecha M, Gudernova I, Fafilek B, Barta T, Basheer N, Abraham SP, Balek L, Tomanova M, Fialova Kucerova J, Bosak J, Potesil D, Zieba J, Song J, Konik P, Park S, Duran I, Zdrahal Z, Smajs D, Jansen G, Fu Z, Ko HW, Hampl A, Trantirek L, Krakow D, Krejci P
Proceedings of the National Academy of Sciences of the United States of America 2019 Mar 5;116(10):4316-4325
Proceedings of the National Academy of Sciences of the United States of America 2019 Mar 5;116(10):4316-4325
Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.
Lodge EJ, Santambrogio A, Russell JP, Xekouki P, Jacques TS, Johnson RL, Thavaraj S, Bornstein SR, Andoniadou CL
eLife 2019 Mar 26;8
eLife 2019 Mar 26;8
HDAC1 and HDAC2 Regulate Intermediate Progenitor Positioning to Safeguard Neocortical Development.
Tang T, Zhang Y, Wang Y, Cai Z, Lu Z, Li L, Huang R, Hagelkruys A, Matthias P, Zhang H, Seiser C, Xie Y
Neuron 2019 Mar 20;101(6):1117-1133.e5
Neuron 2019 Mar 20;101(6):1117-1133.e5
Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.
Kluth O, Stadion M, Gottmann P, Aga H, Jähnert M, Scherneck S, Vogel H, Krus U, Seelig A, Ling C, Gerdes J, Schürmann A
Cell reports 2019 Mar 12;26(11):3027-3036.e3
Cell reports 2019 Mar 12;26(11):3027-3036.e3
The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling.
Massa F, Tammaro R, Prado MA, Cesana M, Lee BH, Finley D, Franco B, Morleo M
Human molecular genetics 2019 Mar 1;28(5):764-777
Human molecular genetics 2019 Mar 1;28(5):764-777
Elevated miR-200a and miR-141 inhibit endocrine gland-derived vascular endothelial growth factor expression and ciliogenesis in preeclampsia.
Wang CY, Tsai PY, Chen TY, Tsai HL, Kuo PL, Su MT
The Journal of physiology 2019 Jun;597(12):3069-3083
The Journal of physiology 2019 Jun;597(12):3069-3083
Fbxo41 Promotes Disassembly of Neuronal Primary Cilia.
King CR, A A Quadros AR, Chazeau A, Saarloos I, van der Graaf AJ, Verhage M, Toonen RF
Scientific reports 2019 Jun 3;9(1):8179
Scientific reports 2019 Jun 3;9(1):8179
Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression.
Lim JP, Nair S, Shyamasundar S, Chua PJ, Muniasamy U, Matsumoto K, Gunaratne J, Bay BH
Cancer letters 2019 Jun 28;452:119-131
Cancer letters 2019 Jun 28;452:119-131
Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis.
Hong H, Joo K, Park SM, Seo J, Kim MH, Shin E, Cheong HI, Lee JH, Kim J
Annals of neurology 2019 Jul;86(1):99-115
Annals of neurology 2019 Jul;86(1):99-115
Characterization of Functional Primary Cilia in Human Induced Pluripotent Stem Cell-Derived Neurons.
Miki D, Kobayashi Y, Okada T, Miyamoto T, Takei N, Sekino Y, Koganezawa N, Shirao T, Saito Y
Neurochemical research 2019 Jul;44(7):1736-1744
Neurochemical research 2019 Jul;44(7):1736-1744
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation.
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT, Knight MM
Osteoarthritis and cartilage 2019 Jul;27(7):1064-1074
Osteoarthritis and cartilage 2019 Jul;27(7):1064-1074
Chloroquine inhibits human retina pigmented epithelial cell growth and microtubule nucleation by downregulating p150glued.
Chen TY, Lien WC, Cheng HL, Kuan TS, Sheu SY, Wang CY
Journal of cellular physiology 2019 Jul;234(7):10445-10457
Journal of cellular physiology 2019 Jul;234(7):10445-10457
Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding.
Mirvis M, Siemers KA, Nelson WJ, Stearns TP
PLoS biology 2019 Jul;17(7):e3000381
PLoS biology 2019 Jul;17(7):e3000381
Ciliopathy-Associated Protein Kinase ICK Requires Its Non-Catalytic Carboxyl-Terminal Domain for Regulation of Ciliogenesis.
Oh YS, Wang EJ, Gailey CD, Brautigan DL, Allen BL, Fu Z
Cells 2019 Jul 4;8(7)
Cells 2019 Jul 4;8(7)
Targeted exon skipping rescues ciliary protein composition defects in Joubert syndrome patient fibroblasts.
Molinari E, Ramsbottom SA, Srivastava S, Booth P, Alkanderi S, McLafferty SM, Devlin LA, White K, Gunay-Aygun M, Miles CG, Sayer JA
Scientific reports 2019 Jul 25;9(1):10828
Scientific reports 2019 Jul 25;9(1):10828
Spastin Contributes to Neural Development through the Regulation of Microtubule Dynamics in the Primary Cilia of Neural Stem Cells.
Jeong B, Kim TH, Kim DS, Shin WH, Lee JR, Kim NS, Lee DY
Neuroscience 2019 Jul 15;411:76-85
Neuroscience 2019 Jul 15;411:76-85
Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs.
Kiseleva AA, Korobeynikov VA, Nikonova AS, Zhang P, Makhov P, Deneka AY, Einarson MB, Serebriiskii IG, Liu H, Peterson JR, Golemis EA
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jul 1;25(13):4179-4193
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Jul 1;25(13):4179-4193
CCDC114 is mutated in patient with a complex phenotype combining primary ciliary dyskinesia, sensorineural deafness, and renal disease.
Li P, He Y, Cai G, Xiao F, Yang J, Li Q, Chen X
Journal of human genetics 2019 Jan;64(1):39-48
Journal of human genetics 2019 Jan;64(1):39-48
Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine.
Kong MJ, Bak SH, Han KH, Kim JI, Park JW, Park KM
Redox biology 2019 Jan;20:38-45
Redox biology 2019 Jan;20:38-45
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines.
Capowski EE, Samimi K, Mayerl SJ, Phillips MJ, Pinilla I, Howden SE, Saha J, Jansen AD, Edwards KL, Jager LD, Barlow K, Valiauga R, Erlichman Z, Hagstrom A, Sinha D, Sluch VM, Chamling X, Zack DJ, Skala MC, Gamm DM
Development (Cambridge, England) 2019 Jan 9;146(1)
Development (Cambridge, England) 2019 Jan 9;146(1)
Hydrocephalus in a rat model of Meckel Gruber syndrome with a TMEM67 mutation.
Shim JW, Territo PR, Simpson S, Watson JC, Jiang L, Riley AA, McCarthy B, Persohn S, Fulkerson D, Blazer-Yost BL
Scientific reports 2019 Jan 31;9(1):1069
Scientific reports 2019 Jan 31;9(1):1069
Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.
Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B
The EMBO journal 2019 Jan 15;38(2)
The EMBO journal 2019 Jan 15;38(2)
Bardet-Biedl Syndrome proteins regulate cilia disassembly during tissue maturation.
Patnaik SR, Kretschmer V, Brücker L, Schneider S, Volz AK, Oancea-Castillo LDR, May-Simera HL
Cellular and molecular life sciences : CMLS 2019 Feb;76(4):757-775
Cellular and molecular life sciences : CMLS 2019 Feb;76(4):757-775
Carbocisteine stimulated an increase in ciliary bend angle via a decrease in [Cl-]i in mouse airway cilia.
Ikeuchi Y, Kogiso H, Hosogi S, Tanaka S, Shimamoto C, Matsumura H, Inui T, Marunaka Y, Nakahari T
Pflugers Archiv : European journal of physiology 2019 Feb;471(2):365-380
Pflugers Archiv : European journal of physiology 2019 Feb;471(2):365-380
Loss of Primary Cilia Results in the Development of Cancer in the Murine Thyroid Gland.
Lee J, Yi S, Chang JY, Kim JT, Sul HJ, Park KC, Zhu X, Cheng SY, Kero J, Kim J, Shong M
Molecules and cells 2019 Feb 28;42(2):113-122
Molecules and cells 2019 Feb 28;42(2):113-122
Recycling endosomal CD133 functions as an inhibitor of autophagy at the pericentrosomal region.
Izumi H, Li Y, Shibaki M, Mori D, Yasunami M, Sato S, Matsunaga H, Mae T, Kodama K, Kamijo T, Kaneko Y, Nakagawara A
Scientific reports 2019 Feb 19;9(1):2236
Scientific reports 2019 Feb 19;9(1):2236
Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases.
Martínez-Hernández R, Serrano-Somavilla A, Ramos-Leví A, Sampedro-Nuñez M, Lens-Pardo A, Muñoz De Nova JL, Triviño JC, González MU, Torné L, Casares-Arias J, Martín-Cófreces NB, Sánchez-Madrid F, Marazuela M
EBioMedicine 2019 Dec;50:329-342
EBioMedicine 2019 Dec;50:329-342
Primary cilia deficiency in neural crest cells models anterior segment dysgenesis in mouse.
Portal C, Rompolas P, Lwigale P, Iomini C
eLife 2019 Dec 17;8
eLife 2019 Dec 17;8
Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
Bae JE, Kang GM, Min SH, Jo DS, Jung YK, Kim K, Kim MS, Cho DH
Cell death & disease 2019 Dec 16;10(12):952
Cell death & disease 2019 Dec 16;10(12):952
AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/- iPSC-Derived RPE Cells.
Brydon EM, Bronstein R, Buskin A, Lako M, Pierce EA, Fernandez-Godino R
Molecular therapy. Methods & clinical development 2019 Dec 13;15:392-402
Molecular therapy. Methods & clinical development 2019 Dec 13;15:392-402
Neutrophil gelatinase-associated lipocalin (NGAL) is localised to the primary cilium in renal tubular epithelial cells - A novel source of urinary biomarkers of renal injury.
Cassidy H, Slyne J, Higgins M, Radford R, Conlon PJ, Watson AJ, Ryan MP, McMorrow T, Slattery C
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165532
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165532
HDAC3 and HDAC8 are required for cilia assembly and elongation.
Park SA, Yoo H, Seol JH, Rhee K
Biology open 2019 Aug 9;8(8)
Biology open 2019 Aug 9;8(8)
Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.
Uzquiano A, Cifuentes-Diaz C, Jabali A, Romero DM, Houllier A, Dingli F, Maillard C, Boland A, Deleuze JF, Loew D, Mancini GMS, Bahi-Buisson N, Ladewig J, Francis F
Cell reports 2019 Aug 6;28(6):1596-1611.e10
Cell reports 2019 Aug 6;28(6):1596-1611.e10
Characterization of an immortalized human small airway basal stem/progenitor cell line with airway region-specific differentiation capacity.
Wang G, Lou HH, Salit J, Leopold PL, Driscoll S, Schymeinsky J, Quast K, Visvanathan S, Fine JS, Thomas MJ, Crystal RG
Respiratory research 2019 Aug 23;20(1):196
Respiratory research 2019 Aug 23;20(1):196
A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia.
Cheong A, Degani R, Tremblay KD, Mager J
Human molecular genetics 2019 Aug 15;28(16):2775-2784
Human molecular genetics 2019 Aug 15;28(16):2775-2784
Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion.
Dupont MA, Humbert C, Huber C, Siour Q, Guerrera IC, Jung V, Christensen A, Pouliet A, Garfa-Traoré M, Nitschké P, Injeyan M, Millar K, Chitayat D, Shannon P, Girisha KM, Shukla A, Mechler C, Lorentzen E, Benmerah A, Cormier-Daire V, Jeanpierre C, Saunier S, Delous M
Human molecular genetics 2019 Aug 15;28(16):2720-2737
Human molecular genetics 2019 Aug 15;28(16):2720-2737
Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase.
Ritter A, Kreis NN, Roth S, Friemel A, Jennewein L, Eichbaum C, Solbach C, Louwen F, Yuan J
Stem cell research & therapy 2019 Aug 14;10(1):255
Stem cell research & therapy 2019 Aug 14;10(1):255
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.
Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S
Cell reports 2019 Aug 13;28(7):1907-1922.e6
Cell reports 2019 Aug 13;28(7):1907-1922.e6
Mutagenesis of putative ciliary genes with the CRISPR/Cas9 system in zebrafish identifies genes required for retinal development.
Hu R, Huang W, Liu J, Jin M, Wu Y, Li J, Wang J, Yu Z, Wang H, Cao Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5248-5256
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5248-5256
Tubular flow activates magnesium transport in the distal convoluted tubule.
Verschuren EHJ, Hoenderop JGJ, Peters DJM, Arjona FJ, Bindels RJM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5034-5044
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5034-5044
The RNA-Protein Interactome of Differentiated Kidney Tubular Epithelial Cells.
Ignarski M, Rill C, Kaiser RWJ, Kaldirim M, Neuhaus R, Esmaillie R, Li X, Klein C, Bohl K, Petersen M, Frese CK, Höhne M, Atanassov I, Rinschen MM, Höpker K, Schermer B, Benzing T, Dieterich C, Fabretti F, Müller RU
Journal of the American Society of Nephrology : JASN 2019 Apr;30(4):564-576
Journal of the American Society of Nephrology : JASN 2019 Apr;30(4):564-576
CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis.
Tsai JJ, Hsu WB, Liu JH, Chang CW, Tang TK
Scientific reports 2019 Apr 15;9(1):6037
Scientific reports 2019 Apr 15;9(1):6037
Glioma cell proliferation is enhanced in the presence of tumor-derived cilia vesicles.
Hoang-Minh LB, Dutra-Clarke M, Breunig JJ, Sarkisian MR
Cilia 2018;7:6
Cilia 2018;7:6
Adenylyl cyclases and TRPV4 mediate Ca2+/cAMP dynamics to enhance fluid flow-induced osteogenesis in osteocytes.
Moore ER, Ryu HS, Zhu YX, Jacobs CR
Journal of molecular biochemistry 2018;7:48-59
Journal of molecular biochemistry 2018;7:48-59
Ciliogenesis is reciprocally regulated by PPARA and NR1H4/FXR through controlling autophagy in vitro and in vivo.
Liu ZQ, Lee JN, Son M, Lim JY, Dutta RK, Maharjan Y, Kwak S, Oh GT, Byun K, Choe SK, Park R
Autophagy 2018;14(6):1011-1027
Autophagy 2018;14(6):1011-1027
Dorsoventral differences in cAMP levels and correlated changes in the subcellular distribution of the PKA catalytic domain, provide further evidence that PKA signaling coordinates dorsoventral patterning of the otocyst.
Ohta S, Schoenwolf GC
Development, growth & differentiation 2018 Sep;60(7):431-441
Development, growth & differentiation 2018 Sep;60(7):431-441
A distal centriolar protein network controls organelle maturation and asymmetry.
Wang L, Failler M, Fu W, Dynlacht BD
Nature communications 2018 Sep 26;9(1):3938
Nature communications 2018 Sep 26;9(1):3938
LRRC45 contributes to early steps of axoneme extension.
Kurtulmus B, Yuan C, Schuy J, Neuner A, Hata S, Kalamakis G, Martin-Villalba A, Pereira G
Journal of cell science 2018 Sep 20;131(18)
Journal of cell science 2018 Sep 20;131(18)
A slow-cycling LGR5 tumour population mediates basal cell carcinoma relapse after therapy.
Sánchez-Danés A, Larsimont JC, Liagre M, Muñoz-Couselo E, Lapouge G, Brisebarre A, Dubois C, Suppa M, Sukumaran V, Del Marmol V, Tabernero J, Blanpain C
Nature 2018 Oct;562(7727):434-438
Nature 2018 Oct;562(7727):434-438
Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa.
de Bruijn SE, Verbakel SK, de Vrieze E, Kremer H, Cremers FPM, Hoyng CB, van den Born LI, Roosing S
Journal of medical genetics 2018 Oct;55(10):705-712
Journal of medical genetics 2018 Oct;55(10):705-712
Characterization of Primary Cilia in Normal Fallopian Tube Epithelium and Serous Tubal Intraepithelial Carcinoma.
Abdelhamed ZA, Ryan TA, Fuller M, Coulson-Gilmer C, Abdelmottaleb DI, Wang TL, Kaun JC, Wang P, Hutson R, Wilkinson N, Bell SM, Johnson CA
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2018 Oct;28(8):1535-1544
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2018 Oct;28(8):1535-1544
The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK.
Stephen LA, ElMaghloob Y, McIlwraith MJ, Yelland T, Castro Sanchez P, Roda-Navarro P, Ismail S
Developmental cell 2018 Oct 8;47(1):122-132.e4
Developmental cell 2018 Oct 8;47(1):122-132.e4
ARL3 Mutations Cause Joubert Syndrome by Disrupting Ciliary Protein Composition.
Alkanderi S, Molinari E, Shaheen R, Elmaghloob Y, Stephen LA, Sammut V, Ramsbottom SA, Srivastava S, Cairns G, Edwards N, Rice SJ, Ewida N, Alhashem A, White K, Miles CG, Steel DH, Alkuraya FS, Ismail S, Sayer JA
American journal of human genetics 2018 Oct 4;103(4):612-620
American journal of human genetics 2018 Oct 4;103(4):612-620
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, Chen J
Nature communications 2018 Oct 30;9(1):4511
Nature communications 2018 Oct 30;9(1):4511
Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function.
Vuolo L, Stevenson NL, Heesom KJ, Stephens DJ
eLife 2018 Oct 16;7
eLife 2018 Oct 16;7
Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.
Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M
Nature communications 2018 Oct 12;9(1):4234
Nature communications 2018 Oct 12;9(1):4234
Membrane association and remodeling by intraflagellar transport protein IFT172.
Wang Q, Taschner M, Ganzinger KA, Kelley C, Villasenor A, Heymann M, Schwille P, Lorentzen E, Mizuno N
Nature communications 2018 Nov 8;9(1):4684
Nature communications 2018 Nov 8;9(1):4684
A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice.
Ford MJ, Yeyati PL, Mali GR, Keighren MA, Waddell SH, Mjoseng HK, Douglas AT, Hall EA, Sakaue-Sawano A, Miyawaki A, Meehan RR, Boulter L, Jackson IJ, Mill P, Mort RL
Developmental cell 2018 Nov 19;47(4):509-523.e5
Developmental cell 2018 Nov 19;47(4):509-523.e5
Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism.
Jeong AL, Ka HI, Han S, Lee S, Lee EW, Soh SJ, Joo HJ, Sumiyasuren B, Park JY, Lim JS, Park JH, Lee MS, Yang Y
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.
Vion AC, Alt S, Klaus-Bergmann A, Szymborska A, Zheng T, Perovic T, Hammoutene A, Oliveira MB, Bartels-Klein E, Hollfinger I, Rautou PE, Bernabeu MO, Gerhardt H
The Journal of cell biology 2018 May 7;217(5):1651-1665
The Journal of cell biology 2018 May 7;217(5):1651-1665
The Joubert syndrome protein ARL13B binds tubulin to maintain uniform distribution of proteins along the ciliary membrane.
Revenkova E, Liu Q, Gusella GL, Iomini C
Journal of cell science 2018 May 4;131(9)
Journal of cell science 2018 May 4;131(9)
Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.
Stevenson NL, Bergen DJM, Xu A, Wyatt E, Henry F, McCaughey J, Vuolo L, Hammond CL, Stephens DJ
Journal of cell science 2018 May 4;131(9)
Journal of cell science 2018 May 4;131(9)
Cell type-specific regulation of ciliary transition zone assembly in vertebrates.
Wiegering A, Dildrop R, Kalfhues L, Spychala A, Kuschel S, Lier JM, Zobel T, Dahmen S, Leu T, Struchtrup A, Legendre F, Vesque C, Schneider-Maunoury S, Saunier S, Rüther U, Gerhardt C
The EMBO journal 2018 May 15;37(10)
The EMBO journal 2018 May 15;37(10)
Loss of Tctn3 causes neuronal apoptosis and neural tube defects in mice.
Wang B, Zhang Y, Dong H, Gong S, Wei B, Luo M, Wang H, Wu X, Liu W, Xu X, Zheng Y, Sun M
Cell death & disease 2018 May 1;9(5):520
Cell death & disease 2018 May 1;9(5):520
Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain.
Sipos É, Komoly S, Ács P
Journal of molecular neuroscience : MN 2018 Mar;64(3):397-409
Journal of molecular neuroscience : MN 2018 Mar;64(3):397-409
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.
Fernández-Barrera J, Bernabé-Rubio M, Casares-Arias J, Rangel L, Fernández-Martín L, Correas I, Alonso MA
The Journal of cell biology 2018 Mar 5;217(3):929-944
The Journal of cell biology 2018 Mar 5;217(3):929-944
Insm1 Induces Neural Progenitor Delamination in Developing Neocortex via Downregulation of the Adherens Junction Belt-Specific Protein Plekha7.
Tavano S, Taverna E, Kalebic N, Haffner C, Namba T, Dahl A, Wilsch-Bräuninger M, Paridaen JTML, Huttner WB
Neuron 2018 Mar 21;97(6):1299-1314.e8
Neuron 2018 Mar 21;97(6):1299-1314.e8
Regulation of ciliary function by fibroblast growth factor signaling identifies FGFR3-related disorders achondroplasia and thanatophoric dysplasia as ciliopathies.
Kunova Bosakova M, Varecha M, Hampl M, Duran I, Nita A, Buchtova M, Dosedelova H, Machat R, Xie Y, Ni Z, Martin JH, Chen L, Jansen G, Krakow D, Krejci P
Human molecular genetics 2018 Mar 15;27(6):1093-1105
Human molecular genetics 2018 Mar 15;27(6):1093-1105
Mice Expressing Myc in Neural Precursors Develop Choroid Plexus and Ciliary Body Tumors.
Shannon ML, Fame RM, Chau KF, Dani N, Calicchio ML, Géléoc GS, Lidov HGW, Alexandrescu S, Lehtinen MK
The American journal of pathology 2018 Jun;188(6):1334-1344
The American journal of pathology 2018 Jun;188(6):1334-1344
Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer.
Jenks AD, Vyse S, Wong JP, Kostaras E, Keller D, Burgoyne T, Shoemark A, Tsalikis A, de la Roche M, Michaelis M, Cinatl J Jr, Huang PH, Tanos BE
Cell reports 2018 Jun 5;23(10):3042-3055
Cell reports 2018 Jun 5;23(10):3042-3055
Targeted deletion of the AAA-ATPase Ruvbl1 in mice disrupts ciliary integrity and causes renal disease and hydrocephalus.
Dafinger C, Rinschen MM, Borgal L, Ehrenberg C, Basten SG, Franke M, Höhne M, Rauh M, Göbel H, Bloch W, Wunderlich FT, Peters DJM, Tasche D, Mishra T, Habbig S, Dötsch J, Müller RU, Brüning JC, Persigehl T, Giles RH, Benzing T, Schermer B, Liebau MC
Experimental & molecular medicine 2018 Jun 28;50(6):1-17
Experimental & molecular medicine 2018 Jun 28;50(6):1-17
Autophagy alteration prevents primary cilium disassembly in RPE1 cells.
Maharjan Y, Lee JN, Kwak S, Lim H, Dutta RK, Liu ZQ, So HS, Park R
Biochemical and biophysical research communications 2018 Jun 2;500(2):242-248
Biochemical and biophysical research communications 2018 Jun 2;500(2):242-248
Cilia protein IFT88 regulates extracellular protease activity by optimizing LRP-1-mediated endocytosis.
Coveney CR, Collins I, Mc Fie M, Chanalaris A, Yamamoto K, Wann AKT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 19;:fj201800334
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jun 19;:fj201800334
Primary cilia-regulated transcriptome in the renal collecting duct.
Mohammed SG, Arjona FJ, Verschuren EHJ, Bakey Z, Alkema W, van Hijum S, Schmidts M, Bindels RJM, Hoenderop JGJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3653-3668
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jul;32(7):3653-3668
CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.
Beyer T, Bolz S, Junger K, Horn N, Moniruzzaman M, Wissinger Y, Ueffing M, Boldt K
Molecular & cellular proteomics : MCP 2018 Jul;17(7):1285-1294
Molecular & cellular proteomics : MCP 2018 Jul;17(7):1285-1294
EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.
Zingg D, Debbache J, Peña-Hernández R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calçada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L
Cancer cell 2018 Jul 9;34(1):69-84.e14
Cancer cell 2018 Jul 9;34(1):69-84.e14
Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.
Park SM, Lim JS, Ramakrishina S, Kim SH, Kim WK, Lee J, Kang HC, Reiter JF, Kim DS, Kim HH, Lee JH
Neuron 2018 Jul 11;99(1):83-97.e7
Neuron 2018 Jul 11;99(1):83-97.e7
Glucose deprivation induces primary cilium formation through mTORC1 inactivation.
Takahashi K, Nagai T, Chiba S, Nakayama K, Mizuno K
Journal of cell science 2018 Jan 8;131(1)
Journal of cell science 2018 Jan 8;131(1)
CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function.
Canning P, Park K, Gonçalves J, Li C, Howard CJ, Sharpe TD, Holt LJ, Pelletier L, Bullock AN, Leroux MR
Cell reports 2018 Jan 23;22(4):885-894
Cell reports 2018 Jan 23;22(4):885-894
Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells.
May-Simera HL, Wan Q, Jha BS, Hartford J, Khristov V, Dejene R, Chang J, Patnaik S, Lu Q, Banerjee P, Silver J, Insinna-Kettenhofen C, Patel D, Lotfi M, Malicdan M, Hotaling N, Maminishkis A, Sridharan R, Brooks B, Miyagishima K, Gunay-Aygun M, Pal R, Westlake C, Miller S, Sharma R, Bharti K
Cell reports 2018 Jan 2;22(1):189-205
Cell reports 2018 Jan 2;22(1):189-205
Functional characterization of tektin-1 in motile cilia and evidence for TEKT1 as a new candidate gene for motile ciliopathies.
Ryan R, Failler M, Reilly ML, Garfa-Traore M, Delous M, Filhol E, Reboul T, Bole-Feysot C, Nitschké P, Baudouin V, Amselem S, Escudier E, Legendre M, Benmerah A, Saunier S
Human molecular genetics 2018 Jan 15;27(2):266-282
Human molecular genetics 2018 Jan 15;27(2):266-282
Ciliogenesis and cell cycle alterations contribute to KIF2A-related malformations of cortical development.
Broix L, Asselin L, Silva CG, Ivanova EL, Tilly P, Gilet JG, Lebrun N, Jagline H, Muraca G, Saillour Y, Drouot N, Reilly ML, Francis F, Benmerah A, Bahi-Buisson N, Belvindrah R, Nguyen L, Godin JD, Chelly J, Hinckelmann MV
Human molecular genetics 2018 Jan 15;27(2):224-238
Human molecular genetics 2018 Jan 15;27(2):224-238
Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Martin L, Kaci N, Estibals V, Goudin N, Garfa-Traore M, Benoist-Lasselin C, Dambroise E, Legeai-Mallet L
Human molecular genetics 2018 Jan 1;27(1):1-13
Human molecular genetics 2018 Jan 1;27(1):1-13
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease.
Wang Q, Cobo-Stark P, Patel V, Somlo S, Han PL, Igarashi P
Kidney international 2018 Feb;93(2):403-415
Kidney international 2018 Feb;93(2):403-415
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
Lee SH, Joo K, Jung EJ, Hong H, Seo J, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.
Kim YJ, Osborn DP, Lee JY, Araki M, Araki K, Mohun T, Känsäkoski J, Brandstack N, Kim HT, Miralles F, Kim CH, Brown NA, Kim HG, Martinez-Barbera JP, Ataliotis P, Raivio T, Layman LC, Kim SH
EMBO reports 2018 Feb;19(2):269-289
EMBO reports 2018 Feb;19(2):269-289
Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition.
Han SJ, Jung JK, Im SS, Lee SR, Jang BC, Park KM, Kim JI
Biochemical and biophysical research communications 2018 Feb 5;496(2):450-454
Biochemical and biophysical research communications 2018 Feb 5;496(2):450-454
DNAAF1 links heart laterality with the AAA+ ATPase RUVBL1 and ciliary intraflagellar transport.
Hartill VL, van de Hoek G, Patel MP, Little R, Watson CM, Berry IR, Shoemark A, Abdelmottaleb D, Parkes E, Bacchelli C, Szymanska K, Knoers NV, Scambler PJ, Ueffing M, Boldt K, Yates R, Winyard PJ, Adler B, Moya E, Hattingh L, Shenoy A, Hogg C, Sheridan E, Roepman R, Norris D, Mitchison HM, Giles RH, Johnson CA
Human molecular genetics 2018 Feb 1;27(3):529-545
Human molecular genetics 2018 Feb 1;27(3):529-545
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurðsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R
American journal of human genetics 2018 Feb 1;102(2):249-265
American journal of human genetics 2018 Feb 1;102(2):249-265
Reconstructing the Human Renal Vascular-Tubular Unit In Vitro.
Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y
Advanced healthcare materials 2018 Dec;7(23):e1801120
Advanced healthcare materials 2018 Dec;7(23):e1801120
Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model.
Ramsbottom SA, Molinari E, Srivastava S, Silberman F, Henry C, Alkanderi S, Devlin LA, White K, Steel DH, Saunier S, Miles CG, Sayer JA
Proceedings of the National Academy of Sciences of the United States of America 2018 Dec 4;115(49):12489-12494
Proceedings of the National Academy of Sciences of the United States of America 2018 Dec 4;115(49):12489-12494
Kinesin-2 and IFT-A act as a complex promoting nuclear localization of β-catenin during Wnt signalling.
Vuong LT, Iomini C, Balmer S, Esposito D, Aaronson SA, Mlodzik M
Nature communications 2018 Dec 13;9(1):5304
Nature communications 2018 Dec 13;9(1):5304
Cullin-3-KCTD10-mediated CEP97 degradation promotes primary cilium formation.
Nagai T, Mukoyama S, Kagiwada H, Goshima N, Mizuno K
Journal of cell science 2018 Dec 12;131(24)
Journal of cell science 2018 Dec 12;131(24)
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY
Nature communications 2018 Dec 11;9(1):5277
Nature communications 2018 Dec 11;9(1):5277
Loss-of-function of IFT88 determines metabolic phenotypes in thyroid cancer.
Lee J, Yi S, Won M, Song YS, Yi HS, Park YJ, Park KC, Kim JT, Chang JY, Lee MJ, Sul HJ, Choi JE, Kim KS, Kero J, Kim J, Shong M
Oncogene 2018 Aug;37(32):4455-4474
Oncogene 2018 Aug;37(32):4455-4474
Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules.
He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, Torline J, Huang Y, Zhao J, Ling K, Hu J
Nature communications 2018 Aug 17;9(1):3310
Nature communications 2018 Aug 17;9(1):3310
Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.
Barny I, Perrault I, Michel C, Soussan M, Goudin N, Rio M, Thomas S, Attié-Bitach T, Hamel C, Dollfus H, Kaplan J, Rozet JM, Gerard X
Human molecular genetics 2018 Aug 1;27(15):2689-2702
Human molecular genetics 2018 Aug 1;27(15):2689-2702
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size.
Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, Papademetris X, Staib LH, Hyder F, Mandeville JB, Grant PE, Im K, Kwak H, Engelhardt JF, Walsh CA, Bae BI
Nature 2018 Apr;556(7701):370-375
Nature 2018 Apr;556(7701):370-375
Mapping GPR88-Venus illuminates a novel role for GPR88 in sensory processing.
Ehrlich AT, Semache M, Bailly J, Wojcik S, Arefin TM, Colley C, Le Gouill C, Gross F, Lukasheva V, Hogue M, Darcq E, Harsan LA, Bouvier M, Kieffer BL
Brain structure & function 2018 Apr;223(3):1275-1296
Brain structure & function 2018 Apr;223(3):1275-1296
Robust interaction of IFT70 with IFT52-IFT88 in the IFT-B complex is required for ciliogenesis.
Takei R, Katoh Y, Nakayama K
Biology open 2018 Apr 30;7(5)
Biology open 2018 Apr 30;7(5)
Centrobin controls primary ciliogenesis in vertebrates.
Ogungbenro YA, Tena TC, Gaboriau D, Lalor P, Dockery P, Philipp M, Morrison CG
The Journal of cell biology 2018 Apr 2;217(4):1205-1215
The Journal of cell biology 2018 Apr 2;217(4):1205-1215
Mutations in IFT-A satellite core component genes IFT43 and IFT121 produce short rib polydactyly syndrome with distinctive campomelia.
Duran I, Taylor SP, Zhang W, Martin J, Qureshi F, Jacques SM, Wallerstein R, Lachman RS, Nickerson DA, Bamshad M, Cohn DH, Krakow D
Cilia 2017;6:7
Cilia 2017;6:7
Abnormal glycosylation in Joubert syndrome type 10.
Kane MS, Davids M, Bond MR, Adams CJ, Grout ME, Phelps IG, O'Day DR, Dempsey JC, Li X, Golas G, Vezina G, Gunay-Aygun M, Hanover JA, Doherty D, He M, Malicdan MCV, Gahl WA, Boerkoel CF
Cilia 2017;6:2
Cilia 2017;6:2
Jasplakinolide induces primary cilium formation through cell rounding and YAP inactivation.
Nagai T, Mizuno K
PloS one 2017;12(8):e0183030
PloS one 2017;12(8):e0183030
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease.
Grzelak CA, Sigglekow ND, Tirnitz-Parker JE, Hamson EJ, Warren A, Maneck B, Chen J, Patkunanathan B, Boland J, Cheng R, Shackel NA, Seth D, Bowen DG, Martelotto LG, Watkins DN, McCaughan GW
PloS one 2017;12(2):e0171480
PloS one 2017;12(2):e0171480
Missense mutations in the WD40 domain of AHI1 cause non-syndromic retinitis pigmentosa.
Nguyen TT, Hull S, Roepman R, van den Born LI, Oud MM, de Vrieze E, Hetterschijt L, Letteboer SJF, van Beersum SEC, Blokland EA, Yntema HG, Cremers FPM, van der Zwaag PA, Arno G, van Wijk E, Webster AR, Haer-Wigman L
Journal of medical genetics 2017 Sep;54(9):624-632
Journal of medical genetics 2017 Sep;54(9):624-632
Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria.
Thorpe SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A, Knight MM
Journal of cellular physiology 2017 Sep;232(9):2407-2417
Journal of cellular physiology 2017 Sep;232(9):2407-2417
The ciliary membrane-associated proteome reveals actin-binding proteins as key components of cilia.
Kohli P, Höhne M, Jüngst C, Bertsch S, Ebert LK, Schauss AC, Benzing T, Rinschen MM, Schermer B
EMBO reports 2017 Sep;18(9):1521-1535
EMBO reports 2017 Sep;18(9):1521-1535
CDK10 Mutations in Humans and Mice Cause Severe Growth Retardation, Spine Malformations, and Developmental Delays.
Windpassinger C, Piard J, Bonnard C, Alfadhel M, Lim S, Bisteau X, Blouin S, Ali NB, Ng AYJ, Lu H, Tohari S, Talib SZA, van Hul N, Caldez MJ, Van Maldergem L, Yigit G, Kayserili H, Youssef SA, Coppola V, de Bruin A, Tessarollo L, Choi H, Rupp V, Roetzer K, Roschger P, Klaushofer K, Altmüller J, Roy S, Venkatesh B, Ganger R, Grill F, Ben Chehida F, Wollnik B, Altunoglu U, Al Kaissi A, Reversade B, Kaldis P
American journal of human genetics 2017 Sep 7;101(3):391-403
American journal of human genetics 2017 Sep 7;101(3):391-403
Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP, Knight MM
European cells & materials 2017 Sep 20;34:128-141
European cells & materials 2017 Sep 20;34:128-141
Primary cilia modulate TLR4-mediated inflammatory responses in hippocampal neurons.
Baek H, Shin HJ, Kim JJ, Shin N, Kim S, Yi MH, Zhang E, Hong J, Kang JW, Kim Y, Kim CS, Kim DW
Journal of neuroinflammation 2017 Sep 19;14(1):189
Journal of neuroinflammation 2017 Sep 19;14(1):189
GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant.
Giddens MM, Wong JC, Schroeder JP, Farrow EG, Smith BM, Owino S, Soden SE, Meyer RC, Saunders C, LePichon JB, Weinshenker D, Escayg A, Hall RA
Neurobiology of disease 2017 Oct;106:181-190
Neurobiology of disease 2017 Oct;106:181-190
Palmitoylation of the ciliary GTPase ARL13b is necessary for its stability and its role in cilia formation.
Roy K, Jerman S, Jozsef L, McNamara T, Onyekaba G, Sun Z, Marin EP
The Journal of biological chemistry 2017 Oct 27;292(43):17703-17717
The Journal of biological chemistry 2017 Oct 27;292(43):17703-17717
Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome.
Prosseda PP, Luo N, Wang B, Alvarado JA, Hu Y, Sun Y
Journal of cell science 2017 Oct 15;130(20):3447-3454
Journal of cell science 2017 Oct 15;130(20):3447-3454
A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.
Schmitz F, Burtscher I, Stauber M, Gossler A, Lickert H
Genesis (New York, N.Y. : 2000) 2017 Nov;55(11)
Genesis (New York, N.Y. : 2000) 2017 Nov;55(11)
Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division.
Schock EN, Brugmann SA
Developmental biology 2017 Nov 15;431(2):168-178
Developmental biology 2017 Nov 15;431(2):168-178
Human Embryonic Stem Cell-Derived Cardiomyocytes Self-Arrange with Areas of Different Subtypes During Differentiation.
Vestergaard ML, Grubb S, Koefoed K, Anderson-Jenkins Z, Grunnet-Lauridsen K, Calloe K, Clausen C, Christensen ST, Møllgård K, Andersen CY
Stem cells and development 2017 Nov 1;26(21):1566-1577
Stem cells and development 2017 Nov 1;26(21):1566-1577
An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations.
Stayner C, Poole CA, McGlashan SR, Pilanthananond M, Brauning R, Markie D, Lett B, Slobbe L, Chae A, Johnstone AC, Jensen CG, McEwan JC, Dittmer K, Parker K, Wiles A, Blackburne W, Leichter A, Leask M, Pinnapureddy A, Jennings M, Horsfield JA, Walker RJ, Eccles MR
Scientific reports 2017 May 9;7(1):1601
Scientific reports 2017 May 9;7(1):1601
Afadin controls cell polarization and mitotic spindle orientation in developing cortical radial glia.
Rakotomamonjy J, Brunner M, Jüschke C, Zang K, Huang EJ, Reichardt LF, Chenn A
Neural development 2017 May 8;12(1):7
Neural development 2017 May 8;12(1):7
Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.
Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, Korhonen E, Smura T, Vapalahti O, Papantonis A, Schmidt-Chanasit J, Riparbelli M, Callaini G, Krönke M, Utermöhlen O, Gopalakrishnan J
Cell stem cell 2017 Mar 2;20(3):397-406.e5
Cell stem cell 2017 Mar 2;20(3):397-406.e5
Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification.
Flanagan AM, Stavenschi E, Basavaraju S, Gaboriau D, Hoey DA, Morrison CG
Molecular biology of the cell 2017 Mar 15;28(6):736-745
Molecular biology of the cell 2017 Mar 15;28(6):736-745
SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice.
Zhao L, Arsenault M, Ng ET, Longmuss E, Chau TC, Hartwig S, Koopman P
Developmental biology 2017 Mar 1;423(1):46-56
Developmental biology 2017 Mar 1;423(1):46-56
Ciliary entry of KIF17 is dependent on its binding to the IFT-B complex via IFT46-IFT56 as well as on its nuclear localization signal.
Funabashi T, Katoh Y, Michisaka S, Terada M, Sugawa M, Nakayama K
Molecular biology of the cell 2017 Mar 1;28(5):624-633
Molecular biology of the cell 2017 Mar 1;28(5):624-633
Primary Cilium-Regulated EG-VEGF Signaling Facilitates Trophoblast Invasion.
Wang CY, Tsai HL, Syu JS, Chen TY, Su MT
Journal of cellular physiology 2017 Jun;232(6):1467-1477
Journal of cellular physiology 2017 Jun;232(6):1467-1477
Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease.
Lu H, Galeano MCR, Ott E, Kaeslin G, Kausalya PJ, Kramer C, Ortiz-Brüchle N, Hilger N, Metzis V, Hiersche M, Tay SY, Tunningley R, Vij S, Courtney AD, Whittle B, Wühl E, Vester U, Hartleben B, Neuber S, Frank V, Little MH, Epting D, Papathanasiou P, Perkins AC, Wright GD, Hunziker W, Gee HY, Otto EA, Zerres K, Hildebrandt F, Roy S, Wicking C, Bergmann C
Nature genetics 2017 Jul;49(7):1025-1034
Nature genetics 2017 Jul;49(7):1025-1034
Guided self-organization and cortical plate formation in human brain organoids.
Lancaster MA, Corsini NS, Wolfinger S, Gustafson EH, Phillips AW, Burkard TR, Otani T, Livesey FJ, Knoblich JA
Nature biotechnology 2017 Jul;35(7):659-666
Nature biotechnology 2017 Jul;35(7):659-666
Ciliary Hedgehog Signaling Restricts Injury-Induced Adipogenesis.
Kopinke D, Roberson EC, Reiter JF
Cell 2017 Jul 13;170(2):340-351.e12
Cell 2017 Jul 13;170(2):340-351.e12
In Vitro Modeling Using Ciliopathy-Patient-Derived Cells Reveals Distinct Cilia Dysfunctions Caused by CEP290 Mutations.
Shimada H, Lu Q, Insinna-Kettenhofen C, Nagashima K, English MA, Semler EM, Mahgerefteh J, Cideciyan AV, Li T, Brooks BP, Gunay-Aygun M, Jacobson SG, Cogliati T, Westlake CJ, Swaroop A
Cell reports 2017 Jul 11;20(2):384-396
Cell reports 2017 Jul 11;20(2):384-396
The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.
Kanie T, Abbott KL, Mooney NA, Plowey ED, Demeter J, Jackson PK
Developmental cell 2017 Jul 10;42(1):22-36.e12
Developmental cell 2017 Jul 10;42(1):22-36.e12
Arl3 and RP2 regulate the trafficking of ciliary tip kinesins.
Schwarz N, Lane A, Jovanovic K, Parfitt DA, Aguila M, Thompson CL, da Cruz L, Coffey PJ, Chapple JP, Hardcastle AJ, Cheetham ME
Human molecular genetics 2017 Jul 1;26(13):2480-2492
Human molecular genetics 2017 Jul 1;26(13):2480-2492
Primary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.
Di Pietro C, Marazziti D, La Sala G, Abbaszadeh Z, Golini E, Matteoni R, Tocchini-Valentini GP
Cellular and molecular neurobiology 2017 Jan;37(1):145-154
Cellular and molecular neurobiology 2017 Jan;37(1):145-154
KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Schou KB, Mogensen JB, Morthorst SK, Nielsen BS, Aleliunaite A, Serra-Marques A, Fürstenberg N, Saunier S, Bizet AA, Veland IR, Akhmanova A, Christensen ST, Pedersen LB
Nature communications 2017 Jan 30;8:14177
Nature communications 2017 Jan 30;8:14177
Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision.
Phua SC, Chiba S, Suzuki M, Su E, Roberson EC, Pusapati GV, Schurmans S, Setou M, Rohatgi R, Reiter JF, Ikegami K, Inoue T
Cell 2017 Jan 12;168(1-2):264-279.e15
Cell 2017 Jan 12;168(1-2):264-279.e15
HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.
Kobayashi T, Nakazono K, Tokuda M, Mashima Y, Dynlacht BD, Itoh H
EMBO reports 2017 Feb;18(2):334-343
EMBO reports 2017 Feb;18(2):334-343
Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
Wang B, Zheng Y, Shi H, Du X, Zhang Y, Wei B, Luo M, Wang H, Wu X, Hua X, Sun M, Xu X
Genes, brain, and behavior 2017 Feb;16(2):296-307
Genes, brain, and behavior 2017 Feb;16(2):296-307
Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.
Nozaki S, Katoh Y, Terada M, Michisaka S, Funabashi T, Takahashi S, Kontani K, Nakayama K
Journal of cell science 2017 Feb 1;130(3):563-576
Journal of cell science 2017 Feb 1;130(3):563-576
A novel homozygous ARL13B variant in patients with Joubert syndrome impairs its guanine nucleotide-exchange factor activity.
Rafiullah R, Long AB, Ivanova AA, Ali H, Berkel S, Mustafa G, Paramasivam N, Schlesner M, Wiemann S, Wade RC, Bolthauser E, Blum M, Kahn RA, Caspary T, Rappold GA
European journal of human genetics : EJHG 2017 Dec;25(12):1324-1334
European journal of human genetics : EJHG 2017 Dec;25(12):1324-1334
Primary Cilium Formation and Ciliary Protein Trafficking Is Regulated by the Atypical MAP Kinase MAPK15 in Caenorhabditis elegans and Human Cells.
Kazatskaya A, Kuhns S, Lambacher NJ, Kennedy JE, Brear AG, McManus GJ, Sengupta P, Blacque OE
Genetics 2017 Dec;207(4):1423-1440
Genetics 2017 Dec;207(4):1423-1440
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.
Taulet N, Vitre B, Anguille C, Douanier A, Rocancourt M, Taschner M, Lorentzen E, Echard A, Delaval B
Nature communications 2017 Dec 4;8(1):1928
Nature communications 2017 Dec 4;8(1):1928
An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells.
Taniguchi K, Shao Y, Townshend RF, Cortez CL, Harris CE, Meshinchi S, Kalantry S, Fu J, O'Shea KS, Gumucio DL
The Journal of cell biology 2017 Dec 4;216(12):3981-3990
The Journal of cell biology 2017 Dec 4;216(12):3981-3990
The guanine nucleotide exchange factor Arf-like protein 13b is essential for assembly of the mouse photoreceptor transition zone and outer segment.
Hanke-Gogokhia C, Wu Z, Sharif A, Yazigi H, Frederick JM, Baehr W
The Journal of biological chemistry 2017 Dec 29;292(52):21442-21456
The Journal of biological chemistry 2017 Dec 29;292(52):21442-21456
Evolutionary Proteomics Uncovers Ancient Associations of Cilia with Signaling Pathways.
Sigg MA, Menchen T, Lee C, Johnson J, Jungnickel MK, Choksi SP, Garcia G 3rd, Busengdal H, Dougherty GW, Pennekamp P, Werner C, Rentzsch F, Florman HM, Krogan N, Wallingford JB, Omran H, Reiter JF
Developmental cell 2017 Dec 18;43(6):744-762.e11
Developmental cell 2017 Dec 18;43(6):744-762.e11
Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.
Bizzotto S, Uzquiano A, Dingli F, Ershov D, Houllier A, Arras G, Richards M, Loew D, Minc N, Croquelois A, Houdusse A, Francis F
Scientific reports 2017 Dec 11;7(1):17308
Scientific reports 2017 Dec 11;7(1):17308
A human patient-derived cellular model of Joubert syndrome reveals ciliary defects which can be rescued with targeted therapies.
Srivastava S, Ramsbottom SA, Molinari E, Alkanderi S, Filby A, White K, Henry C, Saunier S, Miles CG, Sayer JA
Human molecular genetics 2017 Dec 1;26(23):4657-4667
Human molecular genetics 2017 Dec 1;26(23):4657-4667
Folate-dependent methylation of septins governs ciliogenesis during neural tube closure.
Toriyama M, Toriyama M, Wallingford JB, Finnell RH
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3622-3635
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Aug;31(8):3622-3635
A novel role for primary cilia in airway remodeling.
Trempus CS, Song W, Lazrak A, Yu Z, Creighton JR, Young BM, Heise RL, Yu YR, Ingram JL, Tighe RM, Matalon S, Garantziotis S
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L328-L338
American journal of physiology. Lung cellular and molecular physiology 2017 Aug 1;313(2):L328-L338
Primary cilia on porcine testicular somatic cells and their role in hedgehog signaling and tubular morphogenesis in vitro.
Dores C, Alpaugh W, Su L, Biernaskie J, Dobrinski I
Cell and tissue research 2017 Apr;368(1):215-223
Cell and tissue research 2017 Apr;368(1):215-223
Estrogen receptor α is required for oviductal transport of embryos.
Li S, O'Neill SR, Zhang Y, Holtzman MJ, Takemaru KI, Korach KS, Winuthayanon W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1595-1607
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017 Apr;31(4):1595-1607
Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency.
Stephen J, Vilboux T, Mian L, Kuptanon C, Sinclair CM, Yildirimli D, Maynard DM, Bryant J, Fischer R, Vemulapalli M, Mullikin JC, NISC Comparative Sequencing Program., Huizing M, Gahl WA, Malicdan MCV, Gunay-Aygun M
Human genetics 2017 Apr;136(4):399-408
Human genetics 2017 Apr;136(4):399-408
KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability.
Yeyati PL, Schiller R, Mali G, Kasioulis I, Kawamura A, Adams IR, Playfoot C, Gilbert N, van Heyningen V, Wills J, von Kriegsheim A, Finch A, Sakai J, Schofield CJ, Jackson IJ, Mill P
The Journal of cell biology 2017 Apr 3;216(4):999-1013
The Journal of cell biology 2017 Apr 3;216(4):999-1013
Cilia-dependent GLI processing in neural crest cells is required for tongue development.
Millington G, Elliott KH, Chang YT, Chang CF, Dlugosz A, Brugmann SA
Developmental biology 2017 Apr 15;424(2):124-137
Developmental biology 2017 Apr 15;424(2):124-137
Generation of iPSC-derived Human Brain Organoids to Model Early Neurodevelopmental Disorders.
Gabriel E, Gopalakrishnan J
Journal of visualized experiments : JoVE 2017 Apr 14;(122)
Journal of visualized experiments : JoVE 2017 Apr 14;(122)
Practical method for targeted disruption of cilia-related genes by using CRISPR/Cas9-mediated, homology-independent knock-in system.
Katoh Y, Michisaka S, Nozaki S, Funabashi T, Hirano T, Takei R, Nakayama K
Molecular biology of the cell 2017 Apr 1;28(7):898-906
Molecular biology of the cell 2017 Apr 1;28(7):898-906
A novel ICK mutation causes ciliary disruption and lethal endocrine-cerebro-osteodysplasia syndrome.
Oud MM, Bonnard C, Mans DA, Altunoglu U, Tohari S, Ng AYJ, Eskin A, Lee H, Rupar CA, de Wagenaar NP, Wu KM, Lahiry P, Pazour GJ, Nelson SF, Hegele RA, Roepman R, Kayserili H, Venkatesh B, Siu VM, Reversade B, Arts HH
Cilia 2016;5:8
Cilia 2016;5:8
Measuring the primary cilium length: improved method for unbiased high-throughput analysis.
Dummer A, Poelma C, DeRuiter MC, Goumans MJ, Hierck BP
Cilia 2016;5:7
Cilia 2016;5:7
Three-dimensional retinal organoids from mouse pluripotent stem cells mimic in vivo development with enhanced stratification and rod photoreceptor differentiation.
Chen HY, Kaya KD, Dong L, Swaroop A
Molecular vision 2016;22:1077-1094
Molecular vision 2016;22:1077-1094
Morphological and Functional Characterization of the Ciliary Pocket by Electron and Fluorescence Microscopy.
Ghossoub R, Lindbæk L, Molla-Herman A, Schmitt A, Christensen ST, Benmerah A
Methods in molecular biology (Clifton, N.J.) 2016;1454:35-51
Methods in molecular biology (Clifton, N.J.) 2016;1454:35-51
Methods for Visualization of Neuronal Cilia.
Caspary T, Marazziti D, Berbari NF
Methods in molecular biology (Clifton, N.J.) 2016;1454:203-14
Methods in molecular biology (Clifton, N.J.) 2016;1454:203-14
Targeting of ASH Domain-Containing Proteins to the Centrosome.
Verdier P, Morthorst SK, Pedersen LB
Methods in molecular biology (Clifton, N.J.) 2016;1454:15-33
Methods in molecular biology (Clifton, N.J.) 2016;1454:15-33
Immunofluorescent staining of septins in primary cilia.
Kim MS, Froese CD, Xie H, Trimble WS
Methods in cell biology 2016;136:269-83
Methods in cell biology 2016;136:269-83
Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model.
Choi H, Shin JH, Kim ES, Park SJ, Bae IH, Jo YK, Jeong IY, Kim HJ, Lee Y, Park HC, Jeon HB, Kim KW, Lee TR, Cho DH
PloS one 2016;11(12):e0168025
PloS one 2016;11(12):e0168025
KIF3A binds to β-arrestin for suppressing Wnt/β-catenin signalling independently of primary cilia in lung cancer.
Kim M, Suh YA, Oh JH, Lee BR, Kim J, Jang SJ
Scientific reports 2016 Sep 6;6:32770
Scientific reports 2016 Sep 6;6:32770
Destabilization of the IFT-B cilia core complex due to mutations in IFT81 causes a Spectrum of Short-Rib Polydactyly Syndrome.
Duran I, Taylor SP, Zhang W, Martin J, Forlenza KN, Spiro RP, Nickerson DA, Bamshad M, Cohn DH, Krakow D
Scientific reports 2016 Sep 26;6:34232
Scientific reports 2016 Sep 26;6:34232
Nestin Mediates Hedgehog Pathway Tumorigenesis.
Li P, Lee EH, Du F, Gordon RE, Yuelling LW, Liu Y, Ng JM, Zhang H, Wu J, Korshunov A, Pfister SM, Curran T, Yang ZJ
Cancer research 2016 Sep 15;76(18):5573-83
Cancer research 2016 Sep 15;76(18):5573-83
RPGR, a prenylated retinal ciliopathy protein, is targeted to cilia in a prenylation- and PDE6D-dependent manner.
Dutta N, Seo S
Biology open 2016 Sep 15;5(9):1283-9
Biology open 2016 Sep 15;5(9):1283-9
IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome.
Zhang W, Taylor SP, Nevarez L, Lachman RS, Nickerson DA, Bamshad M, University of Washington Center for Mendelian Genomics Consortium., Krakow D, Cohn DH
Human molecular genetics 2016 Sep 15;25(18):4012-4020
Human molecular genetics 2016 Sep 15;25(18):4012-4020
An inactivating mutation in intestinal cell kinase, ICK, impairs hedgehog signalling and causes short rib-polydactyly syndrome.
Paige Taylor S, Kunova Bosakova M, Varecha M, Balek L, Barta T, Trantirek L, Jelinkova I, Duran I, Vesela I, Forlenza KN, Martin JH, Hampl A, University of Washington Center for Mendelian Genomics., Bamshad M, Nickerson D, Jaworski ML, Song J, Ko HW, Cohn DH, Krakow D, Krejci P
Human molecular genetics 2016 Sep 15;25(18):3998-4011
Human molecular genetics 2016 Sep 15;25(18):3998-4011
Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.
Hong CJ, Hamilton BA
PLoS genetics 2016 Oct;12(10):e1006357
PLoS genetics 2016 Oct;12(10):e1006357
Loss of MACF1 Abolishes Ciliogenesis and Disrupts Apicobasal Polarity Establishment in the Retina.
May-Simera HL, Gumerson JD, Gao C, Campos M, Cologna SM, Beyer T, Boldt K, Kaya KD, Patel N, Kretschmer F, Kelley MW, Petralia RS, Davey MG, Li T
Cell reports 2016 Oct 25;17(5):1399-1413
Cell reports 2016 Oct 25;17(5):1399-1413
Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline.
Chang CF, Chang YT, Millington G, Brugmann SA
PLoS genetics 2016 Nov;12(11):e1006351
PLoS genetics 2016 Nov;12(11):e1006351
Defective ciliogenesis in thyroid hürthle cell tumors is associated with increased autophagy.
Lee J, Yi S, Kang YE, Chang JY, Kim JT, Sul HJ, Kim JO, Kim JM, Kim J, Porcelli AM, Kim KS, Shong M
Oncotarget 2016 Nov 29;7(48):79117-79130
Oncotarget 2016 Nov 29;7(48):79117-79130
Neuroanatomical characterization of the cellular and axonal architecture of subcortical band heterotopia in the BXD29-Tlr4lps-2J/J mouse cortex.
Ramos RL, Toia AR, Pasternack DM, Dotzler TP, Cuoco JA, Esposito AW, Le MM, Parker AK, Goodman JH, Sarkisian MR
Neuroscience 2016 Nov 19;337:48-65
Neuroscience 2016 Nov 19;337:48-65
Role for the IFT-A Complex in Selective Transport to the Primary Cilium.
Fu W, Wang L, Kim S, Li J, Dynlacht BD
Cell reports 2016 Nov 1;17(6):1505-1517
Cell reports 2016 Nov 1;17(6):1505-1517
Cyclic expression of the voltage-gated potassium channel KV10.1 promotes disassembly of the primary cilium.
Sánchez A, Urrego D, Pardo LA
EMBO reports 2016 May;17(5):708-23
EMBO reports 2016 May;17(5):708-23
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier Y, van Beersum SE, Horn N, Willer JR, Mans DA, Dougherty G, Lamers IJ, Coene KL, Arts HH, Betts MJ, Beyer T, Bolat E, Gloeckner CJ, Haidari K, Hetterschijt L, Iaconis D, Jenkins D, Klose F, Knapp B, Latour B, Letteboer SJ, Marcelis CL, Mitic D, Morleo M, Oud MM, Riemersma M, Rix S, Terhal PA, Toedt G, van Dam TJ, de Vrieze E, Wissinger Y, Wu KM, Apic G, Beales PL, Blacque OE, Gibson TJ, Huynen MA, Katsanis N, Kremer H, Omran H, van Wijk E, Wolfrum U, Kepes F, Davis EE, Franco B, Giles RH, Ueffing M, Russell RB, Roepman R, UK10K Rare Diseases Group.
Nature communications 2016 May 13;7:11491
Nature communications 2016 May 13;7:11491
Recessive NEK9 mutation causes a lethal skeletal dysplasia with evidence of cell cycle and ciliary defects.
Casey JP, Brennan K, Scheidel N, McGettigan P, Lavin PT, Carter S, Ennis S, Dorkins H, Ghali N, Blacque OE, Mc Gee MM, Murphy H, Lynch SA
Human molecular genetics 2016 May 1;25(9):1824-35
Human molecular genetics 2016 May 1;25(9):1824-35
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
Yadav SP, Sharma NK, Liu C, Dong L, Li T, Swaroop A
Development (Cambridge, England) 2016 May 1;143(9):1491-501
Development (Cambridge, England) 2016 May 1;143(9):1491-501
Arf-like Protein 3 (ARL3) Regulates Protein Trafficking and Ciliogenesis in Mouse Photoreceptors.
Hanke-Gogokhia C, Wu Z, Gerstner CD, Frederick JM, Zhang H, Baehr W
The Journal of biological chemistry 2016 Mar 25;291(13):7142-55
The Journal of biological chemistry 2016 Mar 25;291(13):7142-55
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
Lee SH, Lee MS, Choi TI, Hong H, Seo JY, Kim CH, Kim J
Scientific reports 2016 Jun 6;6:27284
Scientific reports 2016 Jun 6;6:27284
Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups.
Parfitt DA, Lane A, Ramsden CM, Carr AF, Munro PM, Jovanovic K, Schwarz N, Kanuga N, Muthiah MN, Hull S, Gallo JM, da Cruz L, Moore AT, Hardcastle AJ, Coffey PJ, Cheetham ME
Cell stem cell 2016 Jun 2;18(6):769-781
Cell stem cell 2016 Jun 2;18(6):769-781
Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex.
Wang L, Hou S, Han YG
Nature neuroscience 2016 Jul;19(7):888-96
Nature neuroscience 2016 Jul;19(7):888-96
MKS1 regulates ciliary INPP5E levels in Joubert syndrome.
Slaats GG, Isabella CR, Kroes HY, Dempsey JC, Gremmels H, Monroe GR, Phelps IG, Duran KJ, Adkins J, Kumar SA, Knutzen DM, Knoers NV, Mendelsohn NJ, Neubauer D, Mastroyianni SD, Vogt J, Worgan L, Karp N, Bowdin S, Glass IA, Parisi MA, Otto EA, Johnson CA, Hildebrandt F, van Haaften G, Giles RH, Doherty D
Journal of medical genetics 2016 Jan;53(1):62-72
Journal of medical genetics 2016 Jan;53(1):62-72
TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome.
Lambacher NJ, Bruel AL, van Dam TJ, Szymańska K, Slaats GG, Kuhns S, McManus GJ, Kennedy JE, Gaff K, Wu KM, van der Lee R, Burglen L, Doummar D, Rivière JB, Faivre L, Attié-Bitach T, Saunier S, Curd A, Peckham M, Giles RH, Johnson CA, Huynen MA, Thauvin-Robinet C, Blacque OE
Nature cell biology 2016 Jan;18(1):122-31
Nature cell biology 2016 Jan;18(1):122-31
Arl13b and the exocyst interact synergistically in ciliogenesis.
Seixas C, Choi SY, Polgar N, Umberger NL, East MP, Zuo X, Moreiras H, Ghossoub R, Benmerah A, Kahn RA, Fogelgren B, Caspary T, Lipschutz JH, Barral DC
Molecular biology of the cell 2016 Jan 15;27(2):308-20
Molecular biology of the cell 2016 Jan 15;27(2):308-20
Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling.
Thompson CL, Wiles A, Poole CA, Knight MM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):716-26
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Feb;30(2):716-26
NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1.
Zhang C, Zhang W, Lu Y, Yan X, Yan X, Zhu X, Liu W, Yang Y, Zhou T
Cell research 2016 Feb;26(2):239-53
Cell research 2016 Feb;26(2):239-53
Endothelial primary cilia inhibit atherosclerosis.
Dinsmore C, Reiter JF
EMBO reports 2016 Feb;17(2):156-66
EMBO reports 2016 Feb;17(2):156-66
Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis.
Hoang-Minh LB, Deleyrolle LP, Siebzehnrubl D, Ugartemendia G, Futch H, Griffith B, Breunig JJ, De Leon G, Mitchell DA, Semple-Rowland S, Reynolds BA, Sarkisian MR
Oncotarget 2016 Feb 9;7(6):7029-43
Oncotarget 2016 Feb 9;7(6):7029-43
WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.
Kurtulmus B, Wang W, Ruppert T, Neuner A, Cerikan B, Viol L, Dueñas-Sánchez R, Gruss OJ, Pereira G
Journal of cell science 2016 Feb 1;129(3):621-36
Journal of cell science 2016 Feb 1;129(3):621-36
Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts.
Li Y, Tian X, Ma M, Jerman S, Kong S, Somlo S, Sun Z
Journal of the American Society of Nephrology : JASN 2016 Dec;27(12):3628-3638
Journal of the American Society of Nephrology : JASN 2016 Dec;27(12):3628-3638
Airway Epithelial KIF3A Regulates Th2 Responses to Aeroallergens.
Giridhar PV, Bell SM, Sridharan A, Rajavelu P, Kitzmiller JA, Na CL, Kofron M, Brandt EB, Ericksen M, Naren AP, Moon C, Khurana Hershey GK, Whitsett JA
Journal of immunology (Baltimore, Md. : 1950) 2016 Dec 1;197(11):4228-4239
Journal of immunology (Baltimore, Md. : 1950) 2016 Dec 1;197(11):4228-4239
Neonatal seizures induced by pentylenetetrazol or kainic acid disrupt primary cilia growth on developing mouse cortical neurons.
Parker AK, Le MM, Smith TS, Hoang-Minh LB, Atkinson EW, Ugartemendia G, Semple-Rowland S, Coleman JE, Sarkisian MR
Experimental neurology 2016 Aug;282:119-27
Experimental neurology 2016 Aug;282:119-27
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.
Doobin DJ, Kemal S, Dantas TJ, Vallee RB
Nature communications 2016 Aug 24;7:12551
Nature communications 2016 Aug 24;7:12551
Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish.
Song P, Dudinsky L, Fogerty J, Gaivin R, Perkins BD
Investigative ophthalmology & visual science 2016 Aug 1;57(10):4517-26
Investigative ophthalmology & visual science 2016 Aug 1;57(10):4517-26
Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells.
Li L, Grausam KB, Wang J, Lun MP, Ohli J, Lidov HG, Calicchio ML, Zeng E, Salisbury JL, Wechsler-Reya RJ, Lehtinen MK, Schüller U, Zhao H
Nature cell biology 2016 Apr;18(4):418-30
Nature cell biology 2016 Apr;18(4):418-30
CPAP promotes timely cilium disassembly to maintain neural progenitor pool.
Gabriel E, Wason A, Ramani A, Gooi LM, Keller P, Pozniakovsky A, Poser I, Noack F, Telugu NS, Calegari F, Šarić T, Hescheler J, Hyman AA, Gottardo M, Callaini G, Alkuraya FS, Gopalakrishnan J
The EMBO journal 2016 Apr 15;35(8):803-19
The EMBO journal 2016 Apr 15;35(8):803-19
Culture and detection of primary cilia in endothelial cell models.
Lim YC, McGlashan SR, Cooling MT, Long DS
Cilia 2015;4:11
Cilia 2015;4:11
Analysis of primary cilia in the developing mouse brain.
Paridaen JT, Huttner WB, Wilsch-Bräuninger M
Methods in cell biology 2015;127:93-129
Methods in cell biology 2015;127:93-129
Imaging centrosomes and cilia in the mouse kidney.
Hoshi M, Wang J, Jain S, Mahjoub MR
Methods in cell biology 2015;127:1-17
Methods in cell biology 2015;127:1-17
A Group of ent-Kaurane Diterpenoids Inhibit Hedgehog Signaling and Induce Cilia Elongation.
Jiang S, Du J, Kong Q, Li C, Li Y, Sun H, Pu J, Mao B
PloS one 2015;10(10):e0139830
PloS one 2015;10(10):e0139830
Cell Cycle-Dependent Localization of Dynactin Subunit p150 glued at Centrosome.
Chen TY, Syu JS, Han TY, Cheng HL, Lu FI, Wang CY
Journal of cellular biochemistry 2015 Sep;116(9):2049-60
Journal of cellular biochemistry 2015 Sep;116(9):2049-60
Primary Cilia on Horizontal Basal Cells Regulate Regeneration of the Olfactory Epithelium.
Joiner AM, Green WW, McIntyre JC, Allen BL, Schwob JE, Martens JR
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct 7;35(40):13761-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Oct 7;35(40):13761-72
Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization.
Bizet AA, Becker-Heck A, Ryan R, Weber K, Filhol E, Krug P, Halbritter J, Delous M, Lasbennes MC, Linghu B, Oakeley EJ, Zarhrate M, Nitschké P, Garfa-Traore M, Serluca F, Yang F, Bouwmeester T, Pinson L, Cassuto E, Dubot P, Elshakhs NAS, Sahel JA, Salomon R, Drummond IA, Gubler MC, Antignac C, Chibout S, Szustakowski JD, Hildebrandt F, Lorentzen E, Sailer AW, Benmerah A, Saint-Mezard P, Saunier S
Nature communications 2015 Oct 21;6:8666
Nature communications 2015 Oct 21;6:8666
PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism.
Nielsen BS, Malinda RR, Schmid FM, Pedersen SF, Christensen ST, Pedersen LB
Journal of cell science 2015 Oct 1;128(19):3543-9
Journal of cell science 2015 Oct 1;128(19):3543-9
Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.
Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF
PLoS genetics 2015 Nov;11(11):e1005627
PLoS genetics 2015 Nov;11(11):e1005627
The Interaction of CCDC104/BARTL1 with Arl3 and Implications for Ciliary Function.
Lokaj M, Kösling SK, Koerner C, Lange SM, van Beersum SE, van Reeuwijk J, Roepman R, Horn N, Ueffing M, Boldt K, Wittinghofer A
Structure (London, England : 1993) 2015 Nov 3;23(11):2122-32
Structure (London, England : 1993) 2015 Nov 3;23(11):2122-32
Loss of primary cilia in melanoma cells is likely independent of proliferation and cell cycle progression.
Snedecor ER, Sung CC, Moncayo A, Rothstein BE, Mockler DC, Tonnesen MG, Jones EC, Fujita M, Clark RA, Shroyer KR, Chen J
The Journal of investigative dermatology 2015 May;135(5):1456-1458
The Journal of investigative dermatology 2015 May;135(5):1456-1458
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
Hong H, Kim J, Kim J
Biochemical and biophysical research communications 2015 May 22;461(1):180-5
Biochemical and biophysical research communications 2015 May 22;461(1):180-5
Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells.
Nygaard MB, Almstrup K, Lindbæk L, Christensen ST, Svingen T
Scientific reports 2015 May 20;5:10364
Scientific reports 2015 May 20;5:10364
Centrin2 regulates CP110 removal in primary cilium formation.
Prosser SL, Morrison CG
The Journal of cell biology 2015 Mar 16;208(6):693-701
The Journal of cell biology 2015 Mar 16;208(6):693-701
The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.
Carpenter BS, Barry RL, Verhey KJ, Allen BL
Journal of cell science 2015 Mar 1;128(5):1034-50
Journal of cell science 2015 Mar 1;128(5):1034-50
Mutations in DYNC2LI1 disrupt cilia function and cause short rib polydactyly syndrome.
Taylor SP, Dantas TJ, Duran I, Wu S, Lachman RS, University of Washington Center for Mendelian Genomics Consortium., Nelson SF, Cohn DH, Vallee RB, Krakow D
Nature communications 2015 Jun 16;6:7092
Nature communications 2015 Jun 16;6:7092
Ablation of retinal ciliopathy protein RPGR results in altered photoreceptor ciliary composition.
Rao KN, Li L, Anand M, Khanna H
Scientific reports 2015 Jun 11;5:11137
Scientific reports 2015 Jun 11;5:11137
Non-Overlapping Distributions and Functions of the VDAC Family in Ciliogenesis.
Majumder S, Cash A, Fisk HA
Cells 2015 Jul 31;4(3):331-53
Cells 2015 Jul 31;4(3):331-53
A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation.
Lu H, Toh MT, Narasimhan V, Thamilselvam SK, Choksi SP, Roy S
Developmental biology 2015 Jan 15;397(2):225-36
Developmental biology 2015 Jan 15;397(2):225-36
Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
Gainullin VG, Hopp K, Ward CJ, Hommerding CJ, Harris PC
The Journal of clinical investigation 2015 Feb;125(2):607-20
The Journal of clinical investigation 2015 Feb;125(2):607-20
The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.
Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Dynlacht BD, Matsuura S
Cell reports 2015 Feb 10;10(5):664-673
Cell reports 2015 Feb 10;10(5):664-673
Mutations in human homologue of chicken talpid3 gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes.
Malicdan MC, Vilboux T, Stephen J, Maglic D, Mian L, Konzman D, Guo J, Yildirimli D, Bryant J, Fischer R, Zein WM, Snow J, Vemulapalli M, Mullikin JC, Toro C, Solomon BD, Niederhuber JE, NISC Comparative Sequencing Program., Gahl WA, Gunay-Aygun M
Journal of medical genetics 2015 Dec;52(12):830-9
Journal of medical genetics 2015 Dec;52(12):830-9
The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
Singh J, Wen X, Scales SJ
The Journal of biological chemistry 2015 Dec 4;290(49):29663-75
The Journal of biological chemistry 2015 Dec 4;290(49):29663-75
An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes.
Wheway G, Schmidts M, Mans DA, Szymanska K, Nguyen TT, Racher H, Phelps IG, Toedt G, Kennedy J, Wunderlich KA, Sorusch N, Abdelhamed ZA, Natarajan S, Herridge W, van Reeuwijk J, Horn N, Boldt K, Parry DA, Letteboer SJF, Roosing S, Adams M, Bell SM, Bond J, Higgins J, Morrison EE, Tomlinson DC, Slaats GG, van Dam TJP, Huang L, Kessler K, Giessl A, Logan CV, Boyle EA, Shendure J, Anazi S, Aldahmesh M, Al Hazzaa S, Hegele RA, Ober C, Frosk P, Mhanni AA, Chodirker BN, Chudley AE, Lamont R, Bernier FP, Beaulieu CL, Gordon P, Pon RT, Donahue C, Barkovich AJ, Wolf L, Toomes C, Thiel CT, Boycott KM, McKibbin M, Inglehearn CF, UK10K Consortium., University of Washington Center for Mendelian Genomics., Stewart F, Omran H, Huynen MA, Sergouniotis PI, Alkuraya FS, Parboosingh JS, Innes AM, Willoughby CE, Giles RH, Webster AR, Ueffing M, Blacque O, Gleeson JG, Wolfrum U, Beales PL, Gibson T, Doherty D, Mitchison HM, Roepman R, Johnson CA
Nature cell biology 2015 Aug;17(8):1074-1087
Nature cell biology 2015 Aug;17(8):1074-1087
A role for Rab23 in the trafficking of Kif17 to the primary cilium.
Lim YS, Tang BL
Journal of cell science 2015 Aug 15;128(16):2996-3008
Journal of cell science 2015 Aug 15;128(16):2996-3008
Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome.
Datta P, Allamargot C, Hudson JS, Andersen EK, Bhattarai S, Drack AV, Sheffield VC, Seo S
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 11;112(32):E4400-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Aug 11;112(32):E4400-9
BBS4 is necessary for ciliary localization of TrkB receptor and activation by BDNF.
Leitch CC, Zaghloul NA
PloS one 2014;9(5):e98687
PloS one 2014;9(5):e98687
Centrosome-kinase fusions promote oncogenic signaling and disrupt centrosome function in myeloproliferative neoplasms.
Lee JY, Hong WJ, Majeti R, Stearns T
PloS one 2014;9(3):e92641
PloS one 2014;9(3):e92641
Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport.
Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SP, Zhou B, Drummond IA, Schuetz JD, Malicki J, Zhong TP
Nature cell biology 2014 Sep;16(9):841-51
Nature cell biology 2014 Sep;16(9):841-51
Centriole maturation requires regulated Plk1 activity during two consecutive cell cycles.
Kong D, Farmer V, Shukla A, James J, Gruskin R, Kiriyama S, Loncarek J
The Journal of cell biology 2014 Sep 29;206(7):855-65
The Journal of cell biology 2014 Sep 29;206(7):855-65
A mutation in the mouse ttc26 gene leads to impaired hedgehog signaling.
Swiderski RE, Nakano Y, Mullins RF, Seo S, Bánfi B
PLoS genetics 2014 Oct;10(10):e1004689
PLoS genetics 2014 Oct;10(10):e1004689
Primary cilia in the developing pig testis.
Ou Y, Dores C, Rodriguez-Sosa JR, van der Hoorn FA, Dobrinski I
Cell and tissue research 2014 Nov;358(2):597-605
Cell and tissue research 2014 Nov;358(2):597-605
A homozygous missense mutation in the ciliary gene TTC21B causes familial FSGS.
Huynh Cong E, Bizet AA, Boyer O, Woerner S, Gribouval O, Filhol E, Arrondel C, Thomas S, Silbermann F, Canaud G, Hachicha J, Ben Dhia N, Peraldi MN, Harzallah K, Iftene D, Daniel L, Willems M, Noel LH, Bole-Feysot C, Nitschké P, Gubler MC, Mollet G, Saunier S, Antignac C
Journal of the American Society of Nephrology : JASN 2014 Nov;25(11):2435-43
Journal of the American Society of Nephrology : JASN 2014 Nov;25(11):2435-43
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism.
Kim H, Xu H, Yao Q, Li W, Huang Q, Outeda P, Cebotaru V, Chiaravalli M, Boletta A, Piontek K, Germino GG, Weinman EJ, Watnick T, Qian F
Nature communications 2014 Nov 18;5:5482
Nature communications 2014 Nov 18;5:5482
RFX7 is required for the formation of cilia in the neural tube.
Manojlovic Z, Earwood R, Kato A, Stefanovic B, Kato Y
Mechanisms of development 2014 May;132:28-37
Mechanisms of development 2014 May;132:28-37
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.
Stratigopoulos G, Martin Carli JF, O'Day DR, Wang L, Leduc CA, Lanzano P, Chung WK, Rosenbaum M, Egli D, Doherty DA, Leibel RL
Cell metabolism 2014 May 6;19(5):767-79
Cell metabolism 2014 May 6;19(5):767-79
Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes.
Thompson CL, Chapple JP, Knight MM
Osteoarthritis and cartilage 2014 Mar;22(3):490-8
Osteoarthritis and cartilage 2014 Mar;22(3):490-8
SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1.
Zhou X, Fan LX, Li K, Ramchandran R, Calvet JP, Li X
Human molecular genetics 2014 Mar 15;23(6):1644-55
Human molecular genetics 2014 Mar 15;23(6):1644-55
Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis.
Veleri S, Manjunath SH, Fariss RN, May-Simera H, Brooks M, Foskett TA, Gao C, Longo TA, Liu P, Nagashima K, Rachel RA, Li T, Dong L, Swaroop A
Nature communications 2014 Jun 20;5:4207
Nature communications 2014 Jun 20;5:4207
ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport.
Chaya T, Omori Y, Kuwahara R, Furukawa T
The EMBO journal 2014 Jun 2;33(11):1227-42
The EMBO journal 2014 Jun 2;33(11):1227-42
Α-tubulin K40 acetylation is required for contact inhibition of proliferation and cell-substrate adhesion.
Aguilar A, Becker L, Tedeschi T, Heller S, Iomini C, Nachury MV
Molecular biology of the cell 2014 Jun 15;25(12):1854-66
Molecular biology of the cell 2014 Jun 15;25(12):1854-66
Basal body proteins regulate Notch signaling through endosomal trafficking.
Leitch CC, Lodh S, Prieto-Echagüe V, Badano JL, Zaghloul NA
Journal of cell science 2014 Jun 1;127(Pt 11):2407-19
Journal of cell science 2014 Jun 1;127(Pt 11):2407-19
Specific polar subpopulations of astral microtubules control spindle orientation and symmetric neural stem cell division.
Mora-Bermúdez F, Matsuzaki F, Huttner WB
eLife 2014 Jul 4;3
eLife 2014 Jul 4;3
Arhgap36-dependent activation of Gli transcription factors.
Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, Pfister SM, Cho YJ, Chen JK
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 29;111(30):11061-6
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 29;111(30):11061-6
Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole.
Čajánek L, Nigg EA
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 15;111(28):E2841-50
Proceedings of the National Academy of Sciences of the United States of America 2014 Jul 15;111(28):E2841-50
Disruption of the basal body protein POC1B results in autosomal-recessive cone-rod dystrophy.
Roosing S, Lamers IJ, de Vrieze E, van den Born LI, Lambertus S, Arts HH, POC1B Study Group., Peters TA, Hoyng CB, Kremer H, Hetterschijt L, Letteboer SJ, van Wijk E, Roepman R, den Hollander AI, Cremers FP
American journal of human genetics 2014 Aug 7;95(2):131-42
American journal of human genetics 2014 Aug 7;95(2):131-42
The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium.
Wang W, Wu T, Kirschner MW
eLife 2014 Aug 19;3:e03083
eLife 2014 Aug 19;3:e03083
The ciliary protein Ftm is required for ventricular wall and septal development.
Gerhardt C, Lier JM, Kuschel S, Rüther U
PloS one 2013;8(2):e57545
PloS one 2013;8(2):e57545
Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration.
Drivas TG, Holzbaur EL, Bennett J
The Journal of clinical investigation 2013 Oct;123(10):4525-39
The Journal of clinical investigation 2013 Oct;123(10):4525-39
Asymmetric inheritance of centrosome-associated primary cilium membrane directs ciliogenesis after cell division.
Paridaen JT, Wilsch-Bräuninger M, Huttner WB
Cell 2013 Oct 10;155(2):333-44
Cell 2013 Oct 10;155(2):333-44
Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.
Su S, Phua SC, DeRose R, Chiba S, Narita K, Kalugin PN, Katada T, Kontani K, Takeda S, Inoue T
Nature methods 2013 Nov;10(11):1105-7
Nature methods 2013 Nov;10(11):1105-7
Defects in the IFT-B component IFT172 cause Jeune and Mainzer-Saldino syndromes in humans.
Halbritter J, Bizet AA, Schmidts M, Porath JD, Braun DA, Gee HY, McInerney-Leo AM, Krug P, Filhol E, Davis EE, Airik R, Czarnecki PG, Lehman AM, Trnka P, Nitschké P, Bole-Feysot C, Schueler M, Knebelmann B, Burtey S, Szabó AJ, Tory K, Leo PJ, Gardiner B, McKenzie FA, Zankl A, Brown MA, Hartley JL, Maher ER, Li C, Leroux MR, Scambler PJ, Zhan SH, Jones SJ, Kayserili H, Tuysuz B, Moorani KN, Constantinescu A, Krantz ID, Kaplan BS, Shah JV, UK10K Consortium., Hurd TW, Doherty D, Katsanis N, Duncan EL, Otto EA, Beales PL, Mitchison HM, Saunier S, Hildebrandt F
American journal of human genetics 2013 Nov 7;93(5):915-25
American journal of human genetics 2013 Nov 7;93(5):915-25
Reduction of oxidative stress during recovery accelerates normalization of primary cilia length that is altered after ischemic injury in murine kidneys.
Kim JI, Kim J, Jang HS, Noh MR, Lipschutz JH, Park KM
American journal of physiology. Renal physiology 2013 May 15;304(10):F1283-94
American journal of physiology. Renal physiology 2013 May 15;304(10):F1283-94
Visualizing renal primary cilia.
Deane JA, Verghese E, Martelotto LG, Cain JE, Galtseva A, Rosenblum ND, Watkins DN, Ricardo SD
Nephrology (Carlton, Vic.) 2013 Mar;18(3):161-8
Nephrology (Carlton, Vic.) 2013 Mar;18(3):161-8
VDAC3 and Mps1 negatively regulate ciliogenesis.
Majumder S, Fisk HA
Cell cycle (Georgetown, Tex.) 2013 Mar 1;12(5):849-58
Cell cycle (Georgetown, Tex.) 2013 Mar 1;12(5):849-58
Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis.
Liu C, Lin C, Whitaker DT, Bakeri H, Bulgakov OV, Liu P, Lei J, Dong L, Li T, Swaroop A
Human molecular genetics 2013 Jun 1;22(11):2234-46
Human molecular genetics 2013 Jun 1;22(11):2234-46
The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling.
Mukhopadhyay S, Wen X, Ratti N, Loktev A, Rangell L, Scales SJ, Jackson PK
Cell 2013 Jan 17;152(1-2):210-23
Cell 2013 Jan 17;152(1-2):210-23
The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.
Kuhns S, Schmidt KN, Reymann J, Gilbert DF, Neuner A, Hub B, Carvalho R, Wiedemann P, Zentgraf H, Erfle H, Klingmüller U, Boutros M, Pereira G
The Journal of cell biology 2013 Feb 18;200(4):505-22
The Journal of cell biology 2013 Feb 18;200(4):505-22
Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa.
Davidson AE, Schwarz N, Zelinger L, Stern-Schneider G, Shoemark A, Spitzbarth B, Gross M, Laxer U, Sosna J, Sergouniotis PI, Waseem NH, Wilson R, Kahn RA, Plagnol V, Wolfrum U, Banin E, Hardcastle AJ, Cheetham ME, Sharon D, Webster AR
American journal of human genetics 2013 Aug 8;93(2):321-9
American journal of human genetics 2013 Aug 8;93(2):321-9
Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.
Bhogaraju S, Cajanek L, Fort C, Blisnick T, Weber K, Taschner M, Mizuno N, Lamla S, Bastin P, Nigg EA, Lorentzen E
Science (New York, N.Y.) 2013 Aug 30;341(6149):1009-12
Science (New York, N.Y.) 2013 Aug 30;341(6149):1009-12
CCDC41 is required for ciliary vesicle docking to the mother centriole.
Joo K, Kim CG, Lee MS, Moon HY, Lee SH, Kim MJ, Kweon HS, Park WY, Kim CH, Gleeson JG, Kim J
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting.
Humbert MC, Weihbrecht K, Searby CC, Li Y, Pope RM, Sheffield VC, Seo S
Proceedings of the National Academy of Sciences of the United States of America 2012 Nov 27;109(48):19691-6
Proceedings of the National Academy of Sciences of the United States of America 2012 Nov 27;109(48):19691-6
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
Li Y, Zhang Q, Wei Q, Zhang Y, Ling K, Hu J
The Journal of cell biology 2012 Nov 12;199(4):589-98
The Journal of cell biology 2012 Nov 12;199(4):589-98
Basolateral rather than apical primary cilia on neuroepithelial cells committed to delamination.
Wilsch-Bräuninger M, Peters J, Paridaen JT, Huttner WB
Development (Cambridge, England) 2012 Jan;139(1):95-105
Development (Cambridge, England) 2012 Jan;139(1):95-105
A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.
Seo S, Zhang Q, Bugge K, Breslow DK, Searby CC, Nachury MV, Sheffield VC
PLoS genetics 2011 Nov;7(11):e1002358
PLoS genetics 2011 Nov;7(11):e1002358
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.
Chih B, Liu P, Chinn Y, Chalouni C, Komuves LG, Hass PE, Sandoval W, Peterson AS
Nature cell biology 2011 Dec 18;14(1):61-72
Nature cell biology 2011 Dec 18;14(1):61-72
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 17711-1-AP( ARL13B Antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 17711-1-AP(ARL13B antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-ARL13B (IP:17711-1-AP, 3ug; Detection:17711-1-AP 1:1000) with L02 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 17711-1-AP(ARL13B antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 17711-1-AP(ARL13B antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
