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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [4]
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- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- GTX118141 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX118141, RRID:AB_10618876
- Product name
- SESN1 antibody
- Antibody type
- Polyclonal
- Reactivity
- Human
- Host
- Rabbit
Submitted references Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O(2-)· production in cancer cells.
A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.
Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition.
Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.
Cordani M, Butera G, Dando I, Torrens-Mas M, Butturini E, Pacchiana R, Oppici E, Cavallini C, Gasperini S, Tamassia N, Nadal-Serrano M, Coan M, Rossi D, Gaidano G, Caraglia M, Mariotto S, Spizzo R, Roca P, Oliver J, Scupoli MT, Donadelli M
British journal of cancer 2018 Oct;119(8):994-1008
British journal of cancer 2018 Oct;119(8):994-1008
A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging.
Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN
Nature immunology 2017 Mar;18(3):354-363
Nature immunology 2017 Mar;18(3):354-363
Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition.
Cordani M, Oppici E, Dando I, Butturini E, Dalla Pozza E, Nadal-Serrano M, Oliver J, Roca P, Mariotto S, Cellini B, Blandino G, Palmieri M, Di Agostino S, Donadelli M
Molecular oncology 2016 Aug;10(7):1008-29
Molecular oncology 2016 Aug;10(7):1008-29
Autophagy induced by p53-reactivating molecules protects pancreatic cancer cells from apoptosis.
Fiorini C, Menegazzi M, Padroni C, Dando I, Dalla Pozza E, Gregorelli A, Costanzo C, Palmieri M, Donadelli M
Apoptosis : an international journal on programmed cell death 2013 Mar;18(3):337-46
Apoptosis : an international journal on programmed cell death 2013 Mar;18(3):337-46
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Sample (30 ?g of whole cell lysate) A: HepG2 7.5% SDS PAGE GTX118141 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SESN1(GTX118141) antibody at 1:500 dilution.
