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- Product number
- 14208-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14208-1-AP, RRID:AB_2256646
- Product name
- TRIM24 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TRIM24 antibody (Cat. #14208-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer.
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.
The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis.
E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1β-mediated pyroptosis in endometriosis.
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
TRIM24 as an independent prognostic biomarker for prostate cancer.
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.
Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma.
Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor.
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Overexpression of TRIM24 is correlated with the progression of human cervical cancer.
Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.
TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma.
TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.
Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.
Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer.
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery.
Clinical significance and biological roles of TRIM24 in human bladder carcinoma.
TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance.
TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.
TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes.
Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer.
TRIM24 links a non-canonical histone signature to breast cancer.
Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC
Nature communications 2021 Sep 10;12(1):5389
Nature communications 2021 Sep 10;12(1):5389
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD
Nature communications 2021 Nov 18;12(1):6671
Nature communications 2021 Nov 18;12(1):6671
Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.
Jin X, Zhang B, Zhang H, Yu H
Oncogene 2021 Nov 16;
Oncogene 2021 Nov 16;
The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis.
Correa-Vázquez JF, Juárez-Vicente F, García-Gutiérrez P, Barysch SV, Melchior F, García-Domínguez M
Cell death & disease 2021 Mar 22;12(4):305
Cell death & disease 2021 Mar 22;12(4):305
E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase-1/IL-1β-mediated pyroptosis in endometriosis.
Hang Y, Tan L, Chen Q, Liu Q, Jin Y
Cell biology international 2021 Jul;45(7):1561-1570
Cell biology international 2021 Jul;45(7):1561-1570
TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.
Kaiho-Soma A, Akizuki Y, Igarashi K, Endo A, Shoda T, Kawase Y, Demizu Y, Naito M, Saeki Y, Tanaka K, Ohtake F
Molecular cell 2021 Apr 1;81(7):1411-1424.e7
Molecular cell 2021 Apr 1;81(7):1411-1424.e7
BMP8A promotes survival and drug resistance via Nrf2/TRIM24 signaling pathway in clear cell renal cell carcinoma.
Yu YP, Cai LC, Wang XY, Cheng SY, Zhang DM, Jian WG, Wang TD, Yang JK, Yang KB, Zhang C
Cancer science 2020 May;111(5):1555-1566
Cancer science 2020 May;111(5):1555-1566
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
Zhu Q, Yu T, Gan S, Wang Y, Pei Y, Zhao Q, Pei S, Hao S, Yuan J, Xu J, Hou F, Wu X, Peng C, Wu P, Qin J, Xiao Y
The Journal of experimental medicine 2020 Jul 6;217(7)
The Journal of experimental medicine 2020 Jul 6;217(7)
TRIM24 as an independent prognostic biomarker for prostate cancer.
Offermann A, Roth D, Hupe MC, Hohensteiner S, Becker F, Joerg V, Carlsson J, Kuempers C, Ribbat-Idel J, Tharun L, Sailer V, Kirfel J, Svensson M, Andren O, Lubczyk V, Kuefer R, Merseburger AS, Perner S
Urologic oncology 2019 Sep;37(9):576.e1-576.e10
Urologic oncology 2019 Sep;37(9):576.e1-576.e10
Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24.
Yu T, Gan S, Zhu Q, Dai D, Li N, Wang H, Chen X, Hou D, Wang Y, Pan Q, Xu J, Zhang X, Liu J, Pei S, Peng C, Wu P, Romano S, Mao C, Huang M, Zhu X, Shen K, Qin J, Xiao Y
Nature communications 2019 Sep 25;10(1):4353
Nature communications 2019 Sep 25;10(1):4353
Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma.
Wang H, Xue W, Jiang X
BioMed research international 2018;2018:6142843
BioMed research international 2018;2018:6142843
Tripartite Motif Containing 24 Acts as a Novel Coactivator of the Constitutive Active/Androstane Receptor.
Kanno Y, Kure Y, Kobayashi S, Mizuno M, Tsuchiya Y, Yamashita N, Nemoto K, Inouye Y
Drug metabolism and disposition: the biological fate of chemicals 2018 Jan;46(1):46-52
Drug metabolism and disposition: the biological fate of chemicals 2018 Jan;46(1):46-52
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.
Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE
Nature chemical biology 2018 Apr;14(4):405-412
Nature chemical biology 2018 Apr;14(4):405-412
Overexpression of TRIM24 is correlated with the progression of human cervical cancer.
Lin L, Zhao W, Sun B, Wang X, Liu Q
American journal of translational research 2017;9(2):620-628
American journal of translational research 2017;9(2):620-628
Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.
Lv D, Jia F, Hou Y, Sang Y, Alvarez AA, Zhang W, Gao WQ, Hu B, Cheng SY, Ge J, Li Y, Feng H
Cancer research 2017 Nov 15;77(22):6190-6201
Cancer research 2017 Nov 15;77(22):6190-6201
TRIM24 is an oncogenic transcriptional co-activator of STAT3 in glioblastoma.
Lv D, Li Y, Zhang W, Alvarez AA, Song L, Tang J, Gao WQ, Hu B, Cheng SY, Feng H
Nature communications 2017 Nov 13;8(1):1454
Nature communications 2017 Nov 13;8(1):1454
TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels.
Borlepawar A, Rangrez AY, Bernt A, Christen L, Sossalla S, Frank D, Frey N
The Journal of biological chemistry 2017 Jun 16;292(24):10180-10196
The Journal of biological chemistry 2017 Jun 16;292(24):10180-10196
Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.
Chi J, Yang Q, Xie XF, Yang XZ, Zhang MY, Wang HY, Xu GL
Aging 2016 Sep 28;8(9):2204-2221
Aging 2016 Sep 28;8(9):2204-2221
Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer.
Ma L, Yuan L, An J, Barton MC, Zhang Q, Liu Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):14803-14812
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):14803-14812
Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery.
Zhan Y, Kost-Alimova M, Shi X, Leo E, Bardenhagen JP, Shepard HE, Appikonda S, Vangamudi B, Zhao S, Tieu TN, Jiang S, Heffernan TP, Marszalek JR, Toniatti C, Draetta G, Tyler J, Barton M, Jones P, Palmer WS, Geck Do MK, Andersen JN
Epigenetics & chromatin 2015;8:37
Epigenetics & chromatin 2015;8:37
Clinical significance and biological roles of TRIM24 in human bladder carcinoma.
Xue D, Zhang X, Zhang X, Liu J, Li N, Liu C, Liu Y, Wang P
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Sep;36(9):6849-55
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2015 Sep;36(9):6849-55
TRIM24 is upregulated in human gastric cancer and promotes gastric cancer cell growth and chemoresistance.
Miao ZF, Wang ZN, Zhao TT, Xu YY, Wu JH, Liu XY, Xu H, You Y, Xu HM
Virchows Archiv : an international journal of pathology 2015 May;466(5):525-32
Virchows Archiv : an international journal of pathology 2015 May;466(5):525-32
TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.
Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC
Oncogene 2015 May 28;34(22):2836-45
Oncogene 2015 May 28;34(22):2836-45
TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes.
Cui Z, Cao W, Li J, Song X, Mao L, Chen W
PloS one 2013;8(5):e63887
PloS one 2013;8(5):e63887
Overexpression of TRIM24 correlates with tumor progression in non-small cell lung cancer.
Li H, Sun L, Tang Z, Fu L, Xu Y, Li Z, Luo W, Qiu X, Wang E
PloS one 2012;7(5):e37657
PloS one 2012;7(5):e37657
TRIM24 links a non-canonical histone signature to breast cancer.
Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC
Nature 2010 Dec 16;468(7326):927-32
Nature 2010 Dec 16;468(7326):927-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 14208-1-AP(TRIM24 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 14208-1-AP(TRIM24 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TRIM24 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TRIM24. This antibody recognizes human,mouse,rat antigen. The TRIM24 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
