Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- ABIN395048 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Uroporphyrinogen III Synthase (UROS) (AA 1-266) antibody
- Antibody type
- Monoclonal
- Description
- This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Mouse
- Epitope
- AA 1-266
- Isotype
- IgG
- Antibody clone number
- 1E11-B11
- Vial size
- 100 μg
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Submitted references Congenital erythropoietic porphyria: a novel uroporphyrinogen III synthase branchpoint mutation reveals underlying wild-type alternatively spliced transcripts.
Uroporphyrinogen III synthase mutations related to congenital erythropoietic porphyria identify a key helix for protein stability.
Human uroporphyrinogen III synthase: NMR-based mapping of the active site.
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.
Identification of mutations in the uroporphyrinogen III cosynthase gene in German patients with congenital erythropoietic porphyria.
Bishop DF, Schneider-Yin X, Clavero S, Yoo HW, Minder EI, Desnick RJ
Blood 2010 Feb 4;115(5):1062-9
Blood 2010 Feb 4;115(5):1062-9
Uroporphyrinogen III synthase mutations related to congenital erythropoietic porphyria identify a key helix for protein stability.
Fortian A, Castaño D, Ortega G, Laín A, Pons M, Millet O
Biochemistry 2009 Jan 20;48(2):454-61
Biochemistry 2009 Jan 20;48(2):454-61
Human uroporphyrinogen III synthase: NMR-based mapping of the active site.
Cunha L, Kuti M, Bishop DF, Mezei M, Zeng L, Zhou MM, Desnick RJ
Proteins 2008 May 1;71(2):855-73
Proteins 2008 May 1;71(2):855-73
Hypoxia decreases the expression of the two enzymes responsible for producing linear and cyclic tetrapyrroles in the heme biosynthetic pathway.
Vargas PD, Furuyama K, Sassa S, Shibahara S
The FEBS journal 2008 Dec;275(23):5947-59
The FEBS journal 2008 Dec;275(23):5947-59
Identification of mutations in the uroporphyrinogen III cosynthase gene in German patients with congenital erythropoietic porphyria.
Wiederholt T, Poblete-Gutiérrez P, Gardlo K, Goerz G, Bolsen K, Merk HF, Frank J
Physiological research 2006;55 Suppl 2:S85-92
Physiological research 2006;55 Suppl 2:S85-92
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC