CABT-B10688

antibody from Creative Diagnostics

Targeting: MPZL2 EVA, EVA1

No application information provided.

Antibody Data

Product number

CABT-B10688

Provider

Creative Diagnostics

Product name

Mouse anti-Human MPZL2 monoclonal antibody, clone 3F21

Antibody type

Monoclonal

Description

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain