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Learn11245-1-AP
antibody from Proteintech Group
Targeting: P4HB
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB, PO4HB, PROHB
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [31]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- 11245-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11245-1-AP, RRID:AB_2298937
- Product name
- PDI antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PDI antibody (Cat. #11245-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The PERK/PKR-eIF2α Pathway Negatively Regulates Porcine Hemagglutinating Encephalomyelitis Virus Replication by Attenuating Global Protein Translation and Facilitating Stress Granule Formation.
Porcine Circovirus 2 Manipulates the PERK-ERO1α Axis of the Endoplasmic Reticulum To Favor Its Replication by Derepressing Viral DNA from HMGB1 Sequestration within Nuclei.
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval.
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis.
Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry.
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma.
Identification and characterization of novel mutations in MOGS in a Chinese patient with infantile spams.
PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.
NSP2 forms viroplasms during Dendrolimus punctatus cypovirus infection.
Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation.
Defective endoplasmic reticulum export causes proinsulin misfolding in pancreatic β cells.
AKT-mediated phosphorylation of ATG4B impairs mitochondrial activity and enhances the Warburg effect in hepatocellular carcinoma cells.
Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma.
Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.
Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway.
Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.
Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.
Expression of prolyl 4-hydroxylase beta-polypeptide in non-small cell lung cancer treated with Chinese medicines.
Halofuginone improves muscle-cell survival in muscular dystrophies.
Involvement of host stroma cells and tissue fibrosis in pancreatic tumor development in transgenic mice.
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene.
Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling.
Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis.
Shi J, Li Z, Xu R, Zhang J, Zhou Q, Gao R, Lu H, Lan Y, Zhao K, He H, Gao F, He W
Journal of virology 2022 Jan 12;96(1):e0169521
Journal of virology 2022 Jan 12;96(1):e0169521
Porcine Circovirus 2 Manipulates the PERK-ERO1α Axis of the Endoplasmic Reticulum To Favor Its Replication by Derepressing Viral DNA from HMGB1 Sequestration within Nuclei.
Sun R, Deng Z, Han X, Zhang Y, Zhou Y, Shan Y, Fang W, Li X
Journal of virology 2021 Sep 9;95(19):e0100921
Journal of virology 2021 Sep 9;95(19):e0100921
The oncomicropeptide APPLE promotes hematopoietic malignancy by enhancing translation initiation.
Sun L, Wang W, Han C, Huang W, Sun Y, Fang K, Zeng Z, Yang Q, Pan Q, Chen T, Luo X, Chen Y
Molecular cell 2021 Nov 4;81(21):4493-4508.e9
Molecular cell 2021 Nov 4;81(21):4493-4508.e9
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval.
Gerondopoulos A, Bräuer P, Sobajima T, Wu Z, Parker JL, Biggin PC, Barr FA, Newstead S
eLife 2021 Jun 17;10
eLife 2021 Jun 17;10
Sulforaphane Balances Ca2+ Homeostasis Injured by Excessive Fat via Mitochondria-Associated Membrane (MAM).
Tian S, Lei P, Zhang J, Sun Y, Li B, Shan Y
Molecular nutrition & food research 2021 Jul;65(14):e2001076
Molecular nutrition & food research 2021 Jul;65(14):e2001076
A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.
Chhabra NF, Amend AL, Bastidas-Ponce A, Sabrautzki S, Tarquis-Medina M, Sachs S, Rubey M, Lorenz-Depiereux B, Feuchtinger A, Bakhti M, Lickert H, Przemeck GKH, Hrabě de Angelis M
Molecular metabolism 2021 Dec;54:101334
Molecular metabolism 2021 Dec;54:101334
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
Yang L, Zhou X, Sun J, Lei Q, Wang Q, Pan D, Ding M, Ding Y
Cell death & disease 2020 Sep 17;11(9):766
Cell death & disease 2020 Sep 17;11(9):766
Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators.
Li B, Yao J, Guo K, He F, Chen K, Lin Z, Liu S, Huang J, Wu Q, Fang M, Zeng J, Wu Z
European journal of medicinal chemistry 2020 Oct 15;204:112608
European journal of medicinal chemistry 2020 Oct 15;204:112608
Mutations in the coat complex II component SEC23B promote colorectal cancer metastasis.
Yang C, Chen N, Li X, Lu D, Hou Z, Li Y, Jin Y, Gu J, Yin Y
Cell death & disease 2020 Mar 2;11(3):157
Cell death & disease 2020 Mar 2;11(3):157
Role of Ca2+ transients at the node of the mouse embryo in breaking of left-right symmetry.
Mizuno K, Shiozawa K, Katoh TA, Minegishi K, Ide T, Ikawa Y, Nishimura H, Takaoka K, Itabashi T, Iwane AH, Nakai J, Shiratori H, Hamada H
Science advances 2020 Jul;6(30):eaba1195
Science advances 2020 Jul;6(30):eaba1195
TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.
Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE
Journal of lipid research 2020 Jan;61(1):33-44
Journal of lipid research 2020 Jan;61(1):33-44
Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma.
Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N
Scientific reports 2020 Feb 7;10(1):2160
Scientific reports 2020 Feb 7;10(1):2160
Identification and characterization of novel mutations in MOGS in a Chinese patient with infantile spams.
Peiwei Zhao, Peng X, Luo S, Huang Y, Tan L, Shao J, He X
Neurogenetics 2020 Apr;21(2):97-104
Neurogenetics 2020 Apr;21(2):97-104
PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity.
Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ
eLife 2019 Jun 11;8
eLife 2019 Jun 11;8
NSP2 forms viroplasms during Dendrolimus punctatus cypovirus infection.
Xu C, Wang J, Yang J, Lei C, Hu J, Sun X
Virology 2019 Jul;533:68-76
Virology 2019 Jul;533:68-76
Proteomic analysis of retinal pigment epithelium cells after exposure to UVA radiation.
Chen JL, Hung CT, Keller JJ, Lin HC, Wu YJ
BMC ophthalmology 2019 Aug 2;19(1):168
BMC ophthalmology 2019 Aug 2;19(1):168
Defective endoplasmic reticulum export causes proinsulin misfolding in pancreatic β cells.
Zhu R, Li X, Xu J, Barrabi C, Kekulandara D, Woods J, Chen X, Liu M
Molecular and cellular endocrinology 2019 Aug 1;493:110470
Molecular and cellular endocrinology 2019 Aug 1;493:110470
AKT-mediated phosphorylation of ATG4B impairs mitochondrial activity and enhances the Warburg effect in hepatocellular carcinoma cells.
Ni Z, He J, Wu Y, Hu C, Dai X, Yan X, Li B, Li X, Xiong H, Li Y, Li S, Xu L, Li Y, Lian J, He F
Autophagy 2018;14(4):685-701
Autophagy 2018;14(4):685-701
Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma.
Kyani A, Tamura S, Yang S, Shergalis A, Samanta S, Kuang Y, Ljungman M, Neamati N
ChemMedChem 2018 Jan 22;13(2):164-177
ChemMedChem 2018 Jan 22;13(2):164-177
Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.
Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N
Oncotarget 2017 Nov 28;8(61):103543-103556
Oncotarget 2017 Nov 28;8(61):103543-103556
Curcumin enhances the effects of irinotecan on colorectal cancer cells through the generation of reactive oxygen species and activation of the endoplasmic reticulum stress pathway.
Huang YF, Zhu DJ, Chen XW, Chen QK, Luo ZT, Liu CC, Wang GX, Zhang WJ, Liao NZ
Oncotarget 2017 Jun 20;8(25):40264-40275
Oncotarget 2017 Jun 20;8(25):40264-40275
Cytotoxicity of 11-epi-Sinulariolide Acetate Isolated from Cultured Soft Corals on HA22T Cells through the Endoplasmic Reticulum Stress Pathway and Mitochondrial Dysfunction.
Lin JJ, Wang RY, Chen JC, Chiu CC, Liao MH, Wu YJ
International journal of molecular sciences 2016 Oct 27;17(11)
International journal of molecular sciences 2016 Oct 27;17(11)
Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.
Hammers DW, Sleeper MM, Forbes SC, Coker CC, Jirousek MR, Zimmer M, Walter GA, Sweeney HL
JCI insight 2016 Dec 22;1(21):e90341
JCI insight 2016 Dec 22;1(21):e90341
Expression of prolyl 4-hydroxylase beta-polypeptide in non-small cell lung cancer treated with Chinese medicines.
Wang SM, Lin LZ, Zhou DH, Zhou JX, Xiong SQ
Chinese journal of integrative medicine 2015 Sep;21(9):689-96
Chinese journal of integrative medicine 2015 Sep;21(9):689-96
Halofuginone improves muscle-cell survival in muscular dystrophies.
Bodanovsky A, Guttman N, Barzilai-Tutsch H, Genin O, Levy O, Pines M, Halevy O
Biochimica et biophysica acta 2014 Jul;1843(7):1339-47
Biochimica et biophysica acta 2014 Jul;1843(7):1339-47
Involvement of host stroma cells and tissue fibrosis in pancreatic tumor development in transgenic mice.
Spector I, Zilberstein Y, Lavy A, Nagler A, Genin O, Pines M
PloS one 2012;7(7):e41833
PloS one 2012;7(7):e41833
Heart repair by reprogramming non-myocytes with cardiac transcription factors.
Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN
Nature 2012 May 13;485(7400):599-604
Nature 2012 May 13;485(7400):599-604
Moderate calcium channel dysfunction in adult mice with inducible cardiomyocyte-specific excision of the cacnb2 gene.
Meissner M, Weissgerber P, Londoño JE, Prenen J, Link S, Ruppenthal S, Molkentin JD, Lipp P, Nilius B, Freichel M, Flockerzi V
The Journal of biological chemistry 2011 May 6;286(18):15875-82
The Journal of biological chemistry 2011 May 6;286(18):15875-82
Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling.
Smith CL, Baek ST, Sung CY, Tallquist MD
Circulation research 2011 Jun 10;108(12):e15-26
Circulation research 2011 Jun 10;108(12):e15-26
Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis.
Castello-Cros R, Whitaker-Menezes D, Molchansky A, Purkins G, Soslowsky LJ, Beason DP, Sotgia F, Iozzo RV, Lisanti MP
Cell cycle (Georgetown, Tex.) 2011 Jul 1;10(13):2140-50
Cell cycle (Georgetown, Tex.) 2011 Jul 1;10(13):2140-50
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 11245-1-AP(PDIA1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HEK-293 cells using 11245-1-AP( PDI Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 11245-1-AP(PDIA1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDI antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDI. This antibody recognizes human,mouse,rat antigen. The PDI antibody has been validated for the following applications: ELISA, WB, IHC, IF, FC analysis.
