NUS1

This gene encodes a type I single transmembrane domain receptor, which is a subunit of cis-prenyltransferase, and serves as a specific receptor for the neural and cardiovascular regulator Nogo-B. The encoded protein is essential for dolichol synthesis and protein glycosylation. This gene is highly expressed in non-small cell lung carcinomas as well as estrogen receptor-alpha positive breast cancer cells where it promotes epithelial mesenchymal transition. This gene is associated with the poor prognosis of human hepatocellular carcinoma patients. Naturally occurring mutations in this gene cause a congenital disorder of glycosylation and are associated with epilepsy. A knockout of the orthologous gene in mice causes embryonic lethality before day 6.5. Pseudogenes of this gene have been defined on chromosomes 13 and X. [provided by RefSeq, May 2017]

Description

NUS1 dehydrodolichyl diphosphate synthase subunit

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Plasma membrane

Predicted location

Membrane

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

6 (117675469 - 117710727)

Ensembl ID

ENSG00000153989  (ver. 103.38)

Orthologs

Mouse Nus1: ENSMUSG00000023068

UniProt

Q96E22

neXtProt

NX_Q96E22

Human splice variants
Mouse splice variants

Protein structure