BS7987

antibody from Bioworld Technology, Inc
Targeting: HINFP DKFZP434F162, HiNF-P, MIZF, ZNF743
Provider product page for BS7987
Western blot
Immunohistochemistry

Antibody data

Product number
BS7987 - Provider product page
Provider
Bioworld Technology, Inc
Product name
HINFP polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human HINFP.
Description
HiNF-P is a critial transcription factor which is necessay for E2F-independent activation of the Histone H4 multigene family. HiNF-P associates with conserved H4 cell cycle regulatory sequences in vivo. Antisense inhibition of HiNF-P reduces endogenous Histone H4 gene expression. HiNF-P utilizes NPAT/p220, a substrate of the cyclin E/cyclin-dependent kinase 2 (CDK2) kinase complex, as a crucial coactivator to amplify Histone H4 gene transcription. The biological role of HiNF-P is reflected by impeded cell cycle progression into S phase upon antisense-mediated reduction of HiNF-P levels. Research indicates that HiNF-P is the key link in a linear signaling pathway that is initiated with the growth factor-dependent induction of cyclin E/ CDK2 kinase activity at the restriction point and culminates in the activation of Histone H4 genes through HiNF-P at the G1/S phase transition.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
HINFP protein structure - BS7987 shown in red.