675202

antibody from BioLegend
Targeting: NLRP12 CLR19.3, Monarch1, NALP12, PAN6, PYPAF7, RNO2
Provider product page for 675202

Antibody data

Product number
675202 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#675202, RRID:AB_2565493
Product name
Purified anti-NLRP12
Antibody type
Monoclonal
Antigen
Partial human NLRP12 recombinant protein (93-1061 a.a.) expressed in E. coli.
Description
NLRP12, a member of the Nod-like receptor (NLR) family of proteins, was originally suggested to act as an inflammasome forming component and a modulator of NF-κB signaling. Recent studies revealed that NLRP12 plays anti-inflammatory roles, as NLRP12-deficient mice are more susceptible to chemically induced colitis, and show a more severe infiltration of granulocytes and T cells. The colitis induced in NLRP12-/- mice is associated with increased production of proinflammatory cytokines and activation of both NF-κB and ERK signaling pathways. NLRP12 was reported to attenuate canonical NF-κB signaling by inhibiting IRAK-1 phosphorylation. NLRP12 also down-regulates non-canonical NF-κB signaling through interaction with TRAF3 and the NF-κB inducing kinase NIK.
Reactivity
Human, Mouse
Host
Mouse
Conjugate
Unconjugated
Antibody clone number
3D11A53
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
2°C-8°C
Handling
Ambient RT
NLRP12 protein structure - 675202 shown in red.