21800-1-AP

antibody from Proteintech Group

Targeting: EZH2 ENX-1, EZH1, KMT6, KMT6A

Provider product page for 21800-1-AP

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Antibody data

Antibody Data
Antigen structure
References [50]
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Product number: 21800-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#21800-1-AP, RRID:AB_10858790
Product name: EZH2 antibody
Antibody type: Polyclonal
Description: KD/KO validated EZH2 antibody (Cat. #21800-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

EZH2 protein structure - 21800-1-AP shown in red.

Submitted references EZH2 Mediates miR-146a-5p/HIF-1α to Alleviate Inflammation and Glycolysis after Acute Spinal Cord Injury.

Ni S, Yang B, Xia L, Zhang H
Mediators of inflammation 2021;2021:5591582

PRMT5 functionally associates with EZH2 to promote colorectal cancer progression through epigenetically repressing CDKN2B expression.

Yang L, Ma DW, Cao YP, Li DZ, Zhou X, Feng JF, Bao J
Theranostics 2021;11(8):3742-3759

The Role of KDM2B and EZH2 in Regulating the Stemness in Colorectal Cancer Through the PI3K/AKT Pathway.

Sanches JGP, Song B, Zhang Q, Cui X, Yabasin IB, Ntim M, Li X, He J, Zhang Y, Mao J, Lu Y, Li L
Frontiers in oncology 2021;11:637298

Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization.

Wu T, Wang G, Zeng X, Sun Z, Li S, Wang W, Yu B
Cell cycle (Georgetown, Tex.) 2021 Sep;20(18):1799-1811

Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.

Wang C, Qu L, Li S, Yin F, Ji L, Peng W, Luo H, Lu D, Liu X, Chen X, Kong L, Wang X
Journal of medicinal chemistry 2021 Sep 9;64(17):12630-12650

Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1/EZH2 complex in pancreatic cancer.

Sun Y, Ren D, Zhou Y, Shen J, Wu H, Jin X
Cell death & disease 2021 Sep 25;12(10):878

Overexpression of SERPINA3 promotes tumor invasion and migration, epithelial-mesenchymal-transition in triple-negative breast cancer cells.

Zhang Y, Tian J, Qu C, Peng Y, Lei J, Li K, Zong B, Sun L, Liu S
Breast cancer (Tokyo, Japan) 2021 Jul;28(4):859-873

lncRNA SNHG7 promotes cell proliferation in glioma by acting as a competing endogenous RNA and sponging miR-138-5p to regulate EZH2 expression.

Deng Y, Cheng L, Lv Z, Zhu H, Meng X
Oncology letters 2021 Jul;22(1):565

EZH2 is a potential prognostic predictor of glioma.

Chen YN, Hou SQ, Jiang R, Sun JL, Cheng CD, Qian ZR
Journal of cellular and molecular medicine 2021 Jan;25(2):925-936

Clonal Architectures Predict Clinical Outcome in Gastric Adenocarcinoma Based on Genomic Variation, Tumor Evolution, and Heterogeneity.

Ren C, Wu C, Wang N, Lian C, Yang C
Cell transplantation 2021 Jan-Dec;30:963689721989606

EZH2-Inhibited MicroRNA-454-3p Promotes M2 Macrophage Polarization in Glioma.

Qi B, Yang C, Zhu Z, Chen H
Frontiers in cell and developmental biology 2020;8:574940

Expression of EZH2 and P53 and their correlation in ovarian cancer tissues.

Zhai L, Tai WL, Pan YQ, Luo JB, Ma L, Zheng YT, Guo MY, Zhang X
International journal of clinical and experimental pathology 2020;13(3):456-464

miR-137-3p Modulates the Progression of Prostate Cancer by Regulating the JNK3/EZH2 Axis.

Zang Y, Zhu J, Li Q, Tu J, Li X, Hu R, Yang D
OncoTargets and therapy 2020;13:7921-7932

Bisphenol a affects endometrial stromal cells decidualization, involvement of epigenetic regulation.

Xiong Y, Wen X, Liu H, Zhang M, Zhang Y
The Journal of steroid biochemistry and molecular biology 2020 Jun;200:105640

Inhibition of EZH2 attenuates inhibitory synaptic transmission via the pro-inflammatory pathway in rats.

Zhang Y, Han Y, Chen Z, Zhao D, Xia Q
Neuropharmacology 2020 Jul;171:108101

Long noncoding RNA ANRIL promotes the malignant progression of cholangiocarcinoma by epigenetically repressing ERRFI1 expression.

Yu Y, Chen Q, Zhang X, Yang J, Lin K, Ji C, Xu A, Yang L, Miao L
Cancer science 2020 Jul;111(7):2297-2309

Upregulation of nuclear-enriched abundant transcript 1 confers oxaliplatin resistance to gastric cancer.

Li Y, Peng C, Fang C, Huang K
Cell biology international 2020 Feb;44(2):446-455

1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.

Yang R, Chen J, Zhang J, Qin R, Wang R, Qiu Y, Mao Z, Goltzman D, Miao D
Aging cell 2020 Feb;19(2):e13095

BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells.

Huang HC, Cai BH, Suen CS, Lee HY, Hwang MJ, Liu FT, Kannagi R
Cells 2020 Feb 9;9(2)

Knockdown of long non-coding RNA LINC00467 inhibits glioma cell progression via modulation of E2F3 targeted by miR-200a.

Gao S, Duan H, An D, Yi X, Li J, Liao C
Cell cycle (Georgetown, Tex.) 2020 Aug;19(16):2040-2053

P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice.

Li T, Wang F, Dang Y, Dong J, Zhang Y, Zhang C, Liu P, Gao Y, Wang X, Yang S, Lu S
International journal of biological sciences 2019;15(10):2198-2210

Identification and Functional Characterization of a New Splicing Variant of EZH2 in the Central Nervous System.

Li D, Wang HL, Huang X, Gu X, Xue W, Xu Y
International journal of biological sciences 2019;15(1):69-80

MDM2 promotes genome instability by ubiquitinating the transcription factor HBP1.

Cao Z, Xue J, Cheng Y, Wang J, Liu Y, Li H, Jiang W, Li G, Gui Y, Zhang X
Oncogene 2019 Jun;38(24):4835-4855

lncRNA TUG1 Promotes Cisplatin Resistance by Regulating CCND2 via Epigenetically Silencing miR-194-5p in Bladder Cancer.

Yu G, Zhou H, Yao W, Meng L, Lang B
Molecular therapy. Nucleic acids 2019 Jun 7;16:257-271

Effect of EZH2 knockdown on preimplantation development of porcine parthenogenetic embryos.

Cai Q, Niu H, Zhang B, Shi X, Liao M, Chen Z, Mo D, He Z, Chen Y, Cong P
Theriogenology 2019 Jul 1;132:95-105

Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-κB/EZH2/YY1 axis in early-stage colon cancers.

Huang HC, Chao CC, Wu PH, Chung HY, Lee HY, Suen CS, Hwang MJ, Cai BH, Kannagi R
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Feb;1862(2):173-183

ANLN-induced EZH2 upregulation promotes pancreatic cancer progression by mediating miR-218-5p/LASP1 signaling axis.

Wang A, Dai H, Gong Y, Zhang C, Shu J, Luo Y, Jiang Y, Liu W, Bie P
Journal of experimental & clinical cancer research : CR 2019 Aug 8;38(1):347

Long noncoding RNA DANCR regulates proliferation and migration by epigenetically silencing FBP1 in tumorigenesis of cholangiocarcinoma.

Wang N, Zhang C, Wang W, Liu J, Yu Y, Li Y, Zhang M, Ge X, Li Q, Miao L
Cell death & disease 2019 Aug 5;10(8):585

SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer.

Li Z, Qiu R, Qiu X, Tian T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;49(2):463-478

Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome.

Zhao J, Xu J, Wang W, Zhao H, Liu H, Liu X, Liu J, Sun Y, Dunaif A, Du Y, Chen ZJ
EBioMedicine 2018 Oct;36:526-538

Hypermethylated in cancer 1 (HIC1) mediates high glucose induced ROS accumulation in renal tubular epithelial cells by epigenetically repressing SIRT1 transcription.

Zeng S, Wu X, Chen X, Xu H, Zhang T, Xu Y
Biochimica et biophysica acta. Gene regulatory mechanisms 2018 Oct;1861(10):917-927

Epigenetic silencing of tumor suppressor gene CDKN1A by oncogenic long non-coding RNA SNHG1 in cholangiocarcinoma.

Yu Y, Zhang M, Wang N, Li Q, Yang J, Yan S, He X, Ji G, Miao L
Cell death & disease 2018 Jul 3;9(7):746

SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice.

Li M, Hong W, Hao C, Li L, Wu D, Shen A, Lu J, Zheng Y, Li P, Xu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Jan;32(1):500-511

VE-Cadherin-Mediated Epigenetic Regulation of Endothelial Gene Expression.

Morini MF, Giampietro C, Corada M, Pisati F, Lavarone E, Cunha SI, Conze LL, O'Reilly N, Joshi D, Kjaer S, George R, Nye E, Ma A, Jin J, Mitter R, Lupia M, Cavallaro U, Pasini D, Calado DP, Dejana E, Taddei A
Circulation research 2018 Jan 19;122(2):231-245

The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell.

Xu Y, Lian Y, Zhang Y, Huang S, Zuo Q, Yang N, Chen Y, Wu D, Sun L
Journal of cellular and molecular medicine 2018 Feb;22(2):1272-1282

Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.

Zhao H, Wang Z, Tang F, Zhao Y, Feng D, Li Y, Hu Y, Wang C, Zhou J, Tian X, Yao J
Pharmacological research 2018 Feb;128:327-337

Long Non-coding RNA PVT1 Promotes Cell Proliferation and Migration by Silencing ANGPTL4 Expression in Cholangiocarcinoma.

Yu Y, Zhang M, Liu J, Xu B, Yang J, Wang N, Yan S, Wang F, He X, Ji G, Li Q, Miao L
Molecular therapy. Nucleic acids 2018 Dec 7;13:503-513

CUL1 promotes breast cancer metastasis through regulating EZH2-induced the autocrine expression of the cytokines CXCL8 and IL11.

Huang YF, Zhang Z, Zhang M, Chen YS, Song J, Hou PF, Yong HM, Zheng JN, Bai J
Cell death & disease 2018 Dec 18;10(1):2

LncRNA SOX21-AS1 is associated with progression of hepatocellular carcinoma and predicts prognosis through epigenetically silencing p21.

Wei C, Wang H, Xu F, Liu Z, Jiang R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Aug;104:137-144

Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer.

Huang Y, Tao T, Liu C, Guan H, Zhang G, Ling Z, Zhang L, Lu K, Chen S, Xu B, Chen M
International journal of oncology 2017 Feb;50(2):421-431

Histone Modifications Regulate the Developmental Expression of Human Hepatic UDP-Glucuronosyltransferase 1A1.

Nie YL, Meng XG, Liu JY, Yan L, Wang P, Bi HZ, Kan QC, Zhang LR
Drug metabolism and disposition: the biological fate of chemicals 2017 Dec;45(12):1372-1378

Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer.

Li B, Xie F, Zheng FX, Jiang GS, Zeng FQ, Xiao XY
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2017 Dec;37(6):886-890

CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.

Liu Y, Lai S, Ma W, Ke W, Zhang C, Liu S, Zhang Y, Pei F, Li S, Yi M, Shu Y, Shang Y, Liang J, Huang Z
Nature communications 2017 Aug 25;8(1):355

Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells.

Tan S, Ding K, Chong QY, Zhao J, Liu Y, Shao Y, Zhang Y, Yu Q, Xiong Z, Zhang W, Zhang M, Li G, Li X, Kong X, Ahmad A, Wu Z, Wu Q, Zhao X, Lobie PE, Zhu T
The Journal of biological chemistry 2017 Aug 18;292(33):13551-13564

lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal.

Zhu P, Wang Y, Huang G, Ye B, Liu B, Wu J, Du Y, He L, Fan Z
Nature structural & molecular biology 2016 Jul;23(7):631-9

HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.

Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X, Ye L
Cancer research 2016 Jan 15;76(2):293-304

Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.

Cai D, Yuan M, Jia Y, Liu H, Hu Y, Zhao R
The Journal of nutritional biochemistry 2015 Dec;26(12):1622-31

Betaine supplementation in maternal diet modulates the epigenetic regulation of hepatic gluconeogenic genes in neonatal piglets.

Cai D, Jia Y, Song H, Sui S, Lu J, Jiang Z, Zhao R
PloS one 2014;9(8):e105504

A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival.

Hou Z, Zhao W, Zhou J, Shen L, Zhan P, Xu C, Chang C, Bi H, Zou J, Yao X, Huang R, Yu L, Yan J
The international journal of biochemistry & cell biology 2014 Aug;53:380-8

MiR-138 induces renal carcinoma cell senescence by targeting EZH2 and is downregulated in human clear cell renal cell carcinoma.

Liang J, Zhang Y, Jiang G, Liu Z, Xiang W, Chen X, Chen Z, Zhao J
Oncology research 2013;21(2):83-91

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The EZH2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human EZH2. This antibody recognizes human, mouse antigen. The EZH2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 21800-1-AP.pdf

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