Antibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 328702 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#328702, RRID:AB_2269146
- Product name
- Purified anti-human CD148
- Antibody type
- Monoclonal
- Antigen
- PHA-stimulated human PBMC
- Description
- CD148, a receptor-like protein tyrosine phosphatase also known as human protein tyrosine phosphatase-eta (HPTP-eta) or density-enhanced protein tyrosine phosphatase-1 (DEP-1), is involved in signal transduction in leucocytes and is thought to contribute to mechanisms of cellular differentiation. In lymphoid organs, CD148 was found to be widely expressed on B and T cells, granulocytes, macrophages, certain dendritic cells as well as mature thymocytes. The cellular level of CD148 was increased after in vitro activation of peripheral blood leucocytes. CD148 as a leucocyte activation marker and may be involved in the regulation of T cell activation. Leucocytes expressing CD148 are significantly upregulated in inflamed tissues and that a subset of these cells co-expresses the activation marker CD25. In non-lymphoid tissues, CD148 was found to be present on many epithelial cell types with glandular and/or endocrine differentiation as well as on fibrocytes, melanocytes and Schwann cells. Among non-hematopoietic cells, CD148 is expressed by characteristic types of epithelial and non-epithelial cells. Downregulation of CD148 might promote dedifferentiation and autonomous growth of such cells in malignant tumors.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4° C.
Submitted references Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.
Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR
Molecular biology of the cell 2011 Oct;22(19):3609-24
Molecular biology of the cell 2011 Oct;22(19):3609-24
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood granulocytes stained with purified A3, followed by anti-mouse IgG FITC
- Conjugate
- Unconjugated