ABIN334397

antibody from antibodies-online

Targeting: FSCN2 RFSN, RP30

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN334397

Provider

antibodies-online

Proper citation

Antibodies-Online Cat#ABIN334397, RRID:AB_10776047

Product name

anti-Fascin Homolog 2, Actin-Bundling Protein, Retinal (Strongylocentrotus Purpuratus) (FSCN2) (Internal Region) antibody

Antibody type

Polyclonal

Antigen

Peptide with sequence CHHRGSNQLDTNR, from the internal region of the protein sequence according to NP_001070650.1, NP_036550.1.

Description

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Reactivity

Mouse

Host

Goat

Epitope

Internal Region

Vial size

100 μg

Storage

Aliquot and store at -20°C.

Handling

Minimize freezing and thawing.

References

Submitted references

HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2.

Ramakrishnan NA, Drescher MJ, Khan KM, Hatfield JS, Drescher DG
The Journal of biological chemistry 2012 Nov 2;287(45):37628-46

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The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice.

Shin JB, Longo-Guess CM, Gagnon LH, Saylor KW, Dumont RA, Spinelli KJ, Pagana JM, Wilmarth PA, David LL, Gillespie PG, Johnson KR
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jul 21;30(29):9683-94

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Role of fascin in filopodial protrusion.

Vignjevic D, Kojima S, Aratyn Y, Danciu O, Svitkina T, Borisy GG
The Journal of cell biology 2006 Sep 11;174(6):863-75