SPA17

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22. [provided by RefSeq, Jan 2009]

Description

Sperm autoantigenic protein 17

Tissue specificity

Tissue enriched (testis)

Subcell location

Vesicles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (124673844 - 124697518)

Ensembl ID

ENSG00000064199  (ver. 103.38)

Orthologs

Mouse Spa17: ENSMUSG00000001948

UniProt

Q15506

neXtProt

NX_Q15506

Human splice variants
Mouse splice variants

Protein structure