Antibody data
- Antibody Data
- Antigen structure
- References [26]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- 14824-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14824-1-AP, RRID:AB_2134953
- Product name
- LDHB antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated LDHB antibody (Cat. #14824-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Comparative Proteomic Analysis of HPV(+) Oropharyngeal Squamous Cell Carcinoma Recurrence.
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
AMPKα loss promotes KRAS-mediated lung tumorigenesis.
Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease.
Metabolic remodelling during early mouse embryo development.
Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Glutathione S-Transferase Mu-3 Predicts a Better Prognosis and Inhibits Malignant Behavior and Glycolysis in Pancreatic Cancer.
A glycolytic shift in Schwann cells supports injured axons.
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.
Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrin β2/FAK signaling pathway in ovarian cancer.
The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.
LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer.
The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer.
A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin.
Fructose‑1,6‑bisphosphatase‑1 decrease may promote carcinogenesis and chemoresistance in cervical cancer.
Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibiting integrin β5-mediated glycolysis.
Probing early tumor response to radiation therapy using hyperpolarized [1-¹³C]pyruvate in MDA-MB-231 xenografts.
Laser capture microdissection-directed profiling of glycolytic and mTOR pathways in areas of selectively ablated Müller cells in the murine retina.
Differential redox proteomics allows identification of proteins reversibly oxidized at cysteine residues in endothelial cells in response to acute hypoxia.
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Ho AS, Robinson A, Shon W, Laury A, Raedschelders K, Venkatraman V, Holewinski R, Zhang Y, Shiao SL, Chen MM, Mallen-St Clair J, Lin DC, Zumsteg ZS, Van Eyk JE
Journal of proteome research 2022 Jan 7;21(1):200-208
Journal of proteome research 2022 Jan 7;21(1):200-208
Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.
Chen W, Zhang J, Zhong W, Liu Y, Lu Y, Zeng Z, Huang H, Wan X, Meng X, Zou F, Cai S, Dong H
Frontiers in pharmacology 2021;12:744826
Frontiers in pharmacology 2021;12:744826
AMPKα loss promotes KRAS-mediated lung tumorigenesis.
La Montagna M, Shi L, Magee P, Sahoo S, Fassan M, Garofalo M
Cell death and differentiation 2021 Sep;28(9):2673-2689
Cell death and differentiation 2021 Sep;28(9):2673-2689
Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease.
Zhang L, Liu T, Hu C, Zhang X, Zhang Q, Shi K
BMC genomics 2021 Sep 4;22(1):640
BMC genomics 2021 Sep 4;22(1):640
Metabolic remodelling during early mouse embryo development.
Zhao J, Yao K, Yu H, Zhang L, Xu Y, Chen L, Sun Z, Zhu Y, Zhang C, Qian Y, Ji S, Pan H, Zhang M, Chen J, Correia C, Weiskittel T, Lin DW, Zhao Y, Chandrasekaran S, Fu X, Zhang D, Fan HY, Xie W, Li H, Hu Z, Zhang J
Nature metabolism 2021 Oct;3(10):1372-1384
Nature metabolism 2021 Oct;3(10):1372-1384
Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.
Newton DA, Lottes RG, Ryan RM, Spyropoulos DD, Baatz JE
Respiratory research 2021 Oct 28;22(1):278
Respiratory research 2021 Oct 28;22(1):278
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059
Theranostics 2020;10(26):12044-12059
Glutathione S-Transferase Mu-3 Predicts a Better Prognosis and Inhibits Malignant Behavior and Glycolysis in Pancreatic Cancer.
Wang S, Yang J, Ding C, Li J, You L, Dai M, Zhao Y
Frontiers in oncology 2020;10:1539
Frontiers in oncology 2020;10:1539
A glycolytic shift in Schwann cells supports injured axons.
Babetto E, Wong KM, Beirowski B
Nature neuroscience 2020 Oct;23(10):1215-1228
Nature neuroscience 2020 Oct;23(10):1215-1228
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R, Zhang N
Nature communications 2020 Jun 22;11(1):3162
Nature communications 2020 Jun 22;11(1):3162
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.
Arra M, Swarnkar G, Ke K, Otero JE, Ying J, Duan X, Maruyama T, Rai MF, O'Keefe RJ, Mbalaviele G, Shen J, Abu-Amer Y
Nature communications 2020 Jul 9;11(1):3427
Nature communications 2020 Jul 9;11(1):3427
Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes.
Wen J, Wang GL, Yuan HJ, Zhang J, Xie HL, Gong S, Han X, Tan JH
Scientific reports 2020 Feb 17;10(1):2782
Scientific reports 2020 Feb 17;10(1):2782
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
Bufalin inhibits glycolysis-induced cell growth and proliferation through the suppression of Integrin β2/FAK signaling pathway in ovarian cancer.
Li H, Hu S, Pang Y, Li M, Chen L, Liu F, Liu M, Wang Z, Cheng X
American journal of cancer research 2018;8(7):1288-1296
American journal of cancer research 2018;8(7):1288-1296
The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.
Sun Z, Zhu M, Lv P, Cheng L, Wang Q, Tian P, Yan Z, Wen B
Stem cell reports 2018 Sep 11;11(3):741-755
Stem cell reports 2018 Sep 11;11(3):741-755
LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer.
Feng M, Xiong G, Cao Z, Yang G, Zheng S, Qiu J, You L, Zheng L, Zhang T, Zhao Y
Journal of experimental & clinical cancer research : CR 2018 Nov 12;37(1):274
Journal of experimental & clinical cancer research : CR 2018 Nov 12;37(1):274
The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer.
Jiang W, He T, Liu S, Zheng Y, Xiang L, Pei X, Wang Z, Yang H
Journal of hematology & oncology 2018 Dec 14;11(1):139
Journal of hematology & oncology 2018 Dec 14;11(1):139
A large-scale targeted proteomics assay resource based on an in vitro human proteome.
Matsumoto M, Matsuzaki F, Oshikawa K, Goshima N, Mori M, Kawamura Y, Ogawa K, Fukuda E, Nakatsumi H, Natsume T, Fukui K, Horimoto K, Nagashima T, Funayama R, Nakayama K, Nakayama KI
Nature methods 2017 Mar;14(3):251-258
Nature methods 2017 Mar;14(3):251-258
Proteomic analysis indicates that mitochondrial energy metabolism in skeletal muscle tissue is negatively correlated with feed efficiency in pigs.
Fu L, Xu Y, Hou Y, Qi X, Zhou L, Liu H, Luan Y, Jing L, Miao Y, Zhao S, Liu H, Li X
Scientific reports 2017 Mar 27;7:45291
Scientific reports 2017 Mar 27;7:45291
miR-375 Regulates Invasion-Related Proteins Vimentin and L-Plastin.
Jimenez L, Lim J, Burd B, Harris TM, Ow TJ, Kawachi N, Belbin TJ, Angeletti R, Prystowsky MB, Childs G, Segall JE
The American journal of pathology 2017 Jul;187(7):1523-1536
The American journal of pathology 2017 Jul;187(7):1523-1536
Fructose‑1,6‑bisphosphatase‑1 decrease may promote carcinogenesis and chemoresistance in cervical cancer.
Li H, Li M, Pang Y, Liu F, Sheng D, Cheng X
Molecular medicine reports 2017 Dec;16(6):8563-8571
Molecular medicine reports 2017 Dec;16(6):8563-8571
Cisplatin suppresses the growth and proliferation of breast and cervical cancer cell lines by inhibiting integrin β5-mediated glycolysis.
Wang S, Xie J, Li J, Liu F, Wu X, Wang Z
American journal of cancer research 2016;6(5):1108-17
American journal of cancer research 2016;6(5):1108-17
Probing early tumor response to radiation therapy using hyperpolarized [1-¹³C]pyruvate in MDA-MB-231 xenografts.
Chen AP, Chu W, Gu YP, Cunningham CH
PloS one 2013;8(2):e56551
PloS one 2013;8(2):e56551
Laser capture microdissection-directed profiling of glycolytic and mTOR pathways in areas of selectively ablated Müller cells in the murine retina.
Chung SH, Shen W, Gillies MC
Investigative ophthalmology & visual science 2013 Oct 9;54(10):6578-85
Investigative ophthalmology & visual science 2013 Oct 9;54(10):6578-85
Differential redox proteomics allows identification of proteins reversibly oxidized at cysteine residues in endothelial cells in response to acute hypoxia.
Izquierdo-Álvarez A, Ramos E, Villanueva J, Hernansanz-Agustín P, Fernández-Rodríguez R, Tello D, Carrascal M, Martínez-Ruiz A
Journal of proteomics 2012 Sep 18;75(17):5449-62
Journal of proteomics 2012 Sep 18;75(17):5449-62
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth.
Sun Q, Chen X, Ma J, Peng H, Wang F, Zha X, Wang Y, Jing Y, Yang H, Chen R, Chang L, Zhang Y, Goto J, Onda H, Chen T, Wang MR, Lu Y, You H, Kwiatkowski D, Zhang H
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 8;108(10):4129-34
Proceedings of the National Academy of Sciences of the United States of America 2011 Mar 8;108(10):4129-34
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 14824-1-AP(LDHB antibody) at dilution of 1:2000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using LDHB antibody 14824-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate using 14824-1-AP(LDHB antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate using 14824-1-AP(LDHB antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue