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Western blot
ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Western blot [1]
- ELISA [1]
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- Product number
- AF3888 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Sheep Polyclonal Proprotein Convertase 9/PCSK9 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human PCSK9 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse PCSK9 is observed.
- Reactivity
- Human
- Host
- Sheep
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references 6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells.
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function.
Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis.
Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor.
Li X, Guo J, Liang N, Jiang X, Song Y, Ou S, Hu Y, Jiao R, Bai W
Frontiers in pharmacology 2018;9:159
Frontiers in pharmacology 2018;9:159
Heparan sulfate proteoglycans present PCSK9 to the LDL receptor.
Gustafsen C, Olsen D, Vilstrup J, Lund S, Reinhardt A, Wellner N, Larsen T, Andersen CBF, Weyer K, Li JP, Seeberger PH, Thirup S, Madsen P, Glerup S
Nature communications 2017 Sep 11;8(1):503
Nature communications 2017 Sep 11;8(1):503
Common Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Epitopes Mediate Multiple Routes for Internalization and Function.
DeVay RM, Yamamoto L, Shelton DL, Liang H
PloS one 2015;10(4):e0125127
PloS one 2015;10(4):e0125127
Loss of plasma proprotein convertase subtilisin/kexin 9 (PCSK9) after lipoprotein apheresis.
Tavori H, Giunzioni I, Linton MF, Fazio S
Circulation research 2013 Dec 6;113(12):1290-5
Circulation research 2013 Dec 6;113(12):1290-5
Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor.
Duff CJ, Scott MJ, Kirby IT, Hutchinson SE, Martin SL, Hooper NM
The Biochemical journal 2009 May 1;419(3):577-84
The Biochemical journal 2009 May 1;419(3):577-84
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human Proprotein Convertase 9/PCSK9 by Western Blot. Detection of Human Proprotein Convertase 9/PCSK9 by Western Blot.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Human Proprotein Convertase 9/PCSK9 ELISA Standard Curve. Human Proprotein Convertase 9/PCSK9 ELISA Standard Curve.
