MAB8228

antibody from Abnova Corporation

Targeting: PCSK9 FH3, HCHOLA3, NARC-1

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

MAB8228

Provider

Abnova Corporation

Proper citation

Abnova Corporation Cat#MAB8228, RRID:AB_10615313

Product name

PCSK9 (prodomain) monoclonal antibody, clone KS-2C8

Antibody type

Monoclonal

Description

Mouse monoclonal antibody raised against full length recombinant PCSK9.

Isotype

IgG

Antibody clone number

KS-2C8

Storage

Store at -20°C.Aliquot to avoid repeated freezing and thawing.

References

Submitted references

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.

Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH
The Journal of biological chemistry 2007 Jun 22;282(25):18602-12

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Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.

Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD
The Journal of clinical investigation 2006 Nov;116(11):2995-3005

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Effect of mutations in the PCSK9 gene on the cell surface LDL receptors.

Cameron J, Holla ØL, Ranheim T, Kulseth MA, Berge KE, Leren TP
Human molecular genetics 2006 May 1;15(9):1551-8

Western blot

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Western blot analysis of PCSK9 (prodomain) monoclonal antibody, clone KS-2C8 (Cat # MAB8228).Lane 1: purified PCSK9-HisLane 2 : PCSK9-His expressing 293 cellLane 3 : HepG2 culture supernatantLane 4 : HepG2 cellLane 5 : A-431 cell