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- References [20]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 55206-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55206-1-AP, RRID:AB_10918272
- Product name
- PCSK9 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PCSK9 antibody (Cat. #55206-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.
Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.
PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.
Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.
Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36.
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma.
Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.
The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.
Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.
Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.
Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH
Frontiers in cardiovascular medicine 2021;8:691336
Frontiers in cardiovascular medicine 2021;8:691336
Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.
Barisione C, Verzola D, Garibaldi S, Ferrari PF, Garibotto G, Ameri P, Pane B, Spinella G, Pratesi G, Palombo D
International journal of molecular sciences 2021 Sep 13;22(18)
International journal of molecular sciences 2021 Sep 13;22(18)
Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.
Wang J, Wang Y, Yang X, Lin P, Liu N, Li X, Zhang B, Guo S
International journal of biological macromolecules 2021 May 15;179:407-417
International journal of biological macromolecules 2021 May 15;179:407-417
PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.
Zhang SZ, Zhu XD, Feng LH, Li XL, Liu XF, Sun HC, Tang ZY
Experimental hematology & oncology 2021 Mar 31;10(1):25
Experimental hematology & oncology 2021 Mar 31;10(1):25
Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.
Yang X, Lin P, Wang J, Liu N, Yin F, Shen N, Guo S
International journal of biological macromolecules 2021 Jun 30;181:890-904
International journal of biological macromolecules 2021 Jun 30;181:890-904
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.
Choi YJ, Lee SJ, Kim HI, Lee HJ, Kang SJ, Kim TY, Cheon C, Ko SG
Scientific reports 2020 Nov 16;10(1):19834
Scientific reports 2020 Nov 16;10(1):19834
Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36.
Nergiz-Unal R, Ulug E, Kisioglu B, Tamer F, Bodur M, Yalcimin H, Yuruk AA
Nutrition (Burbank, Los Angeles County, Calif.) 2020 Nov - Dec;79-80:110954
Nutrition (Burbank, Los Angeles County, Calif.) 2020 Nov - Dec;79-80:110954
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.
Li T, Hu SM, Pang XY, Wang JF, Yin JY, Li FH, Wang J, Yang XQ, Xia B, Liu YH, Song WG, Guo SD
Journal of cellular and molecular medicine 2020 Mar;24(6):3384-3398
Journal of cellular and molecular medicine 2020 Mar;24(6):3384-3398
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY
Nature 2020 Dec;588(7839):693-698
Nature 2020 Dec;588(7839):693-698
Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma.
He L, Chen J, Xu F, Li J, Li J
Molecular therapy oncolytics 2020 Dec 16;19:265-277
Molecular therapy oncolytics 2020 Dec 16;19:265-277
Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.
Wang M, Zhao D, Xu L, Guo W, Nie L, Lei Y, Long Y, Liu M, Wang Y, Zhang X, Zhang L, Li H, Zhang J, Yuan D, Yue L
Metabolism: clinical and experimental 2019 May;94:47-58
Metabolism: clinical and experimental 2019 May;94:47-58
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Xiao J, Bai XQ, Liao L, Zhou M, Peng J, Xiang Q, Ren Z, Wen HY, Jiang ZS, Tang ZH, Wang MM, Liu LS
International journal of molecular medicine 2019 May;43(5):2055-2063
International journal of molecular medicine 2019 May;43(5):2055-2063
Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.
Yang Z, Liu G, Wang Y, Yin J, Wang J, Xia B, Li T, Yang X, Hou P, Hu S, Song W, Guo S
Journal of agricultural and food chemistry 2019 May 22;67(20):5782-5791
Journal of agricultural and food chemistry 2019 May 22;67(20):5782-5791
The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.
Yin J, Wang J, Li F, Yang Z, Yang X, Sun W, Xia B, Li T, Song W, Guo S
Food & function 2019 Aug 1;10(8):5124-5139
Food & function 2019 Aug 1;10(8):5124-5139
Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.
Cao S, Xu P, Yan J, Liu H, Liu L, Cheng L, Qiu F, Kang N
Journal of cellular biochemistry 2018 Oct 18;
Journal of cellular biochemistry 2018 Oct 18;
Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.
Wang Y, Wu T, Hu D, Weng X, Wang X, Chen PJ, Luo X, Wang H, Ning Q
Journal of lipid research 2018 Jan;59(1):58-68
Journal of lipid research 2018 Jan;59(1):58-68
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
Liu LS, Bai XQ, Gao Y, Wu Q, Ren Z, Li Q, Pan LH, He NY, Peng J, Tang ZH
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.
Zhao XS, Wu Q, Peng J, Pan LH, Ren Z, Liu HT, Jiang ZS, Wang GX, Tang ZH, Liu LS
Molecular medicine reports 2017 Feb;15(2):712-718
Molecular medicine reports 2017 Feb;15(2):712-718
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 55206-1-AP(PCSK9 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 55206-1-AP(PCSK9 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PCSK9 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PCSK9. This antibody recognizes human,mouse,rat antigen. The PCSK9 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
