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Western blot
Immunocytochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [10]
- Comments [0]
- Validations
- Immunocytochemistry [1]
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- Product number
- ALX-804-650-C100 - Provider product page
- Provider
- Enzo Life Sciences
- Proper citation
- Enzo Life Sciences Cat#ALX-804-650-C100, RRID:AB_2052744
- Product name
- Trop-2 (human) monoclonal antibody (MOv16)
- Antibody type
- Monoclonal
- Antigen
- Purified from natural sources
- Description
- Protein G-affinity purified.
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- MOv16
- Vial size
- 100 μg
- Storage
- +4°C
- Handling
- Avoid freeze/thaw cycles.
Submitted references Pr1E11, a novel anti-TROP-2 antibody isolated by adenovirus-based antibody screening, recognizes a unique epitope.
Clinical significance of TROP2 expression in colorectal cancer.
Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy.
In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set.
Effects of different immunolabeling techniques on the detection of small-cell lung cancer cells in bone marrow.
Human Trop-2 is a tumor-associated calcium signal transducer.
Transformation of human keratinocytes is characterized by quantitative and qualitative alterations of the T-16 antigen (Trop-2, MOv-16).
Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2.
Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity.
Human trophoblast cell-surface antigens defined by monoclonal antibodies.
Ikeda M, Yamaguchi M, Kato K, Nakamura K, Shiina S, Ichikawa-Ando T, Misaka H, Myojo K, Nakamura K, Sugimoto Y, Hamada H
Biochemical and biophysical research communications 2015 Mar 20;458(4):877-82
Biochemical and biophysical research communications 2015 Mar 20;458(4):877-82
Clinical significance of TROP2 expression in colorectal cancer.
Ohmachi T, Tanaka F, Mimori K, Inoue H, Yanaga K, Mori M
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 May 15;12(10):3057-63
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 May 15;12(10):3057-63
Gene expression profiles in primary ovarian serous papillary tumors and normal ovarian epithelium: identification of candidate molecular markers for ovarian cancer diagnosis and therapy.
Santin AD, Zhan F, Bellone S, Palmieri M, Cane S, Bignotti E, Anfossi S, Gokden M, Dunn D, Roman JJ, O'Brien TJ, Tian E, Cannon MJ, Shaughnessy J Jr, Pecorelli S
International journal of cancer 2004 Oct 20;112(1):14-25
International journal of cancer 2004 Oct 20;112(1):14-25
In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set.
Gerritsen ME, Soriano R, Yang S, Ingle G, Zlot C, Toy K, Winer J, Draksharapu A, Peale F, Wu TD, Williams PM
Physiological genomics 2002 Jul 12;10(1):13-20
Physiological genomics 2002 Jul 12;10(1):13-20
Effects of different immunolabeling techniques on the detection of small-cell lung cancer cells in bone marrow.
Pelosi G, Pasini F, Pavanel F, Bresaola E, Schiavon I, Iannucci A
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Aug;47(8):1075-88
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999 Aug;47(8):1075-88
Human Trop-2 is a tumor-associated calcium signal transducer.
Ripani E, Sacchetti A, Corda D, Alberti S
International journal of cancer 1998 May 29;76(5):671-6
International journal of cancer 1998 May 29;76(5):671-6
Transformation of human keratinocytes is characterized by quantitative and qualitative alterations of the T-16 antigen (Trop-2, MOv-16).
Schön MP, Orfanos CE
International journal of cancer 1995 Jan 3;60(1):88-92
International journal of cancer 1995 Jan 3;60(1):88-92
Biochemical characterization of Trop-2, a cell surface molecule expressed by human carcinomas: formal proof that the monoclonal antibodies T16 and MOv-16 recognize Trop-2.
Alberti S, Miotti S, Stella M, Klein CE, Fornaro M, Menard S, Colnaghi MI
Hybridoma 1992 Oct;11(5):539-45
Hybridoma 1992 Oct;11(5):539-45
Characterization of human ovarian carcinoma-associated antigens defined by novel monoclonal antibodies with tumor-restricted specificity.
Miotti S, Canevari S, Ménard S, Mezzanzanica D, Porro G, Pupa SM, Regazzoni M, Tagliabue E, Colnaghi MI
International journal of cancer 1987 Mar 15;39(3):297-303
International journal of cancer 1987 Mar 15;39(3):297-303
Human trophoblast cell-surface antigens defined by monoclonal antibodies.
Lipinski M, Parks DR, Rouse RV, Herzenberg LA
Proceedings of the National Academy of Sciences of the United States of America 1981 Aug;78(8):5147-50
Proceedings of the National Academy of Sciences of the United States of America 1981 Aug;78(8):5147-50
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Supportive validation
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- Enzo Life Sciences (provider)
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- Experimental details
- FACS profiles of human cancer cell lines using MAb to Trop-2 (human) (MOv16) (Prod. No. ALX-804-650). Method: Human cancer cell lines of breast (MCF7 and BT474) and ovary (OVCA432) origin were treated for 30 min. at +4¡C with MAb to Trop-2 (human) (MOv16) (10µg/ml) or diluent (control), followed by further incubation with anti-mouse Ig FITC.
