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- References [19]
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- Product number
- 13618-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13618-1-AP, RRID:AB_2256858
- Product name
- TTL antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TTL antibody (Cat. #13618-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.
TTL-Expression Modulates Epithelial Morphogenesis.
MARK4 controls ischaemic heart failure through microtubule detyrosination.
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.
Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.
α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity.
Tubulin detyrosination promotes human trophoblast syncytium formation.
PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.
Nuclear envelope assembly defects link mitotic errors to chromothripsis.
Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.
The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice.
Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration.
Vasohibins encode tubulin detyrosinating activity.
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
Mitosis. Microtubule detyrosination guides chromosomes during mitosis.
Tubulin-tyrosine Ligase (TTL)-mediated Increase in Tyrosinated α-Tubulin in Injured Axons Is Required for Retrograde Injury Signaling and Axon Regeneration.
Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells.
Kang Y, Yin S, Liu J, Jiang Y, Huang Z, Chen L, Shao L
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
Journal of hazardous materials 2022 Feb 15;424(Pt D):127660
TTL-Expression Modulates Epithelial Morphogenesis.
Müller M, Ringer K, Hub F, Kamm N, Worzfeld T, Jacob R
Frontiers in cell and developmental biology 2021;9:635723
Frontiers in cell and developmental biology 2021;9:635723
MARK4 controls ischaemic heart failure through microtubule detyrosination.
Yu X, Chen X, Amrute-Nayak M, Allgeyer E, Zhao A, Chenoweth H, Clement M, Harrison J, Doreth C, Sirinakis G, Krieg T, Zhou H, Huang H, Tokuraku K, Johnston DS, Mallat Z, Li X
Nature 2021 Jun;594(7864):560-565
Nature 2021 Jun;594(7864):560-565
Pathogenic role of delta 2 tubulin in bortezomib-induced peripheral neuropathy.
Pero ME, Meregalli C, Qu X, Shin GJ, Kumar A, Shorey M, Rolls MM, Tanji K, Brannagan TH, Alberti P, Fumagalli G, Monza L, Grueber WB, Cavaletti G, Bartolini F
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jan 26;118(4)
Microtubule-associated protein 1B dysregulates microtubule dynamics and neuronal mitochondrial transport in spinal muscular atrophy.
Bora G, Hensel N, Rademacher S, Koyunoğlu D, Sunguroğlu M, Aksu-Mengeş E, Balcı-Hayta B, Claus P, Erdem-Yurter H
Human molecular genetics 2021 Feb 25;29(24):3935-3944
Human molecular genetics 2021 Feb 25;29(24):3935-3944
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.
Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi K, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL
Circulation research 2020 Jul 3;127(2):e14-e27
Circulation research 2020 Jul 3;127(2):e14-e27
α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity.
Ferreira LT, Orr B, Rajendraprasad G, Pereira AJ, Lemos C, Lima JT, Guasch Boldú C, Ferreira JG, Barisic M, Maiato H
The Journal of cell biology 2020 Apr 6;219(4)
The Journal of cell biology 2020 Apr 6;219(4)
Tubulin detyrosination promotes human trophoblast syncytium formation.
Wang R, Yu R, Zhu C, Lin HY, Lu X, Wang H
Journal of molecular cell biology 2019 Dec 23;11(11):967-978
Journal of molecular cell biology 2019 Dec 23;11(11):967-978
PTEN suppresses axon outgrowth by down-regulating the level of detyrosinated microtubules.
Kath C, Goni-Oliver P, Müller R, Schultz C, Haucke V, Eickholt B, Schmoranzer J
PloS one 2018;13(4):e0193257
PloS one 2018;13(4):e0193257
Nuclear envelope assembly defects link mitotic errors to chromothripsis.
Liu S, Kwon M, Mannino M, Yang N, Renda F, Khodjakov A, Pellman D
Nature 2018 Sep;561(7724):551-555
Nature 2018 Sep;561(7724):551-555
Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.
Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL
Nature medicine 2018 Aug;24(8):1225-1233
Nature medicine 2018 Aug;24(8):1225-1233
The Effects of Guizhi Gancao Decoction on Pressure Overload-Induced Heart Failure and Posttranslational Modifications of Tubulin in Mice.
Chen HH, Zhao P, Tian J, Guo W, Xu M, Zhang C, Lu R
Evidence-based complementary and alternative medicine : eCAM 2017;2017:2915247
Evidence-based complementary and alternative medicine : eCAM 2017;2017:2915247
Extracellular matrix stiffness and cell contractility control RNA localization to promote cell migration.
Wang T, Hamilla S, Cam M, Aranda-Espinoza H, Mili S
Nature communications 2017 Oct 12;8(1):896
Nature communications 2017 Oct 12;8(1):896
Vasohibins encode tubulin detyrosinating activity.
Nieuwenhuis J, Adamopoulos A, Bleijerveld OB, Mazouzi A, Stickel E, Celie P, Altelaar M, Knipscheer P, Perrakis A, Blomen VA, Brummelkamp TR
Science (New York, N.Y.) 2017 Dec 15;358(6369):1453-1456
Science (New York, N.Y.) 2017 Dec 15;358(6369):1453-1456
AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.
Herms A, Bosch M, Reddy BJ, Schieber NL, Fajardo A, Rupérez C, Fernández-Vidal A, Ferguson C, Rentero C, Tebar F, Enrich C, Parton RG, Gross SP, Pol A
Nature communications 2015 May 27;6:7176
Nature communications 2015 May 27;6:7176
Mitosis. Microtubule detyrosination guides chromosomes during mitosis.
Barisic M, Silva e Sousa R, Tripathy SK, Magiera MM, Zaytsev AV, Pereira AL, Janke C, Grishchuk EL, Maiato H
Science (New York, N.Y.) 2015 May 15;348(6236):799-803
Science (New York, N.Y.) 2015 May 15;348(6236):799-803
Tubulin-tyrosine Ligase (TTL)-mediated Increase in Tyrosinated α-Tubulin in Injured Axons Is Required for Retrograde Injury Signaling and Axon Regeneration.
Song W, Cho Y, Watt D, Cavalli V
The Journal of biological chemistry 2015 Jun 5;290(23):14765-75
The Journal of biological chemistry 2015 Jun 5;290(23):14765-75
Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO
The Journal of cell biology 2013 Feb 4;200(3):259-70
The Journal of cell biology 2013 Feb 4;200(3):259-70
Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells.
Zink S, Grosse L, Freikamp A, Bänfer S, Müksch F, Jacob R
Journal of cell science 2012 Dec 15;125(Pt 24):5998-6008
Journal of cell science 2012 Dec 15;125(Pt 24):5998-6008
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TTL antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TTL. This antibody recognizes human,mouse,rat antigen. The TTL antibody has been validated for the following applications: ELISA, WB analysis.
