KATNA1

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]

Description

Katanin catalytic subunit A1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Centriolar satellite

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (149594873 - 149648972)

Ensembl ID

ENSG00000186625  (ver. 103.38)

Orthologs

Mouse Katna1: ENSMUSG00000019794

UniProt

O75449

neXtProt

NX_O75449

Human splice variants
Mouse splice variants

Protein structure