CABT-L1448

antibody from Creative Diagnostics

Targeting: LATS1 WARTS

Western blot (Recommended by provider)

Antibody Data

Product number

CABT-L1448

Provider

Creative Diagnostics

Product name

Rabbit Anti-Human LATS1 monoclonal antibody, clone 3I54M7

Antibody type

Monoclonal

Description

LATS1 is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3I54M7

Concentration

0.5 mg/ml

Storage

-20°C, Avoid Freeze/Thaw Cycles