CABT-B12025

antibody from Creative Diagnostics

Targeting: PLXND1 KIAA0620

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-B12025

Provider

Creative Diagnostics

Product name

Human anti-Human PLXND1 recombinant monoclonal antibody, clone SFB653 [PE]

Antibody type

Monoclonal

Description

It recognozes the human plexin-D1 antigen, a type I transmembrane glycoprotein that is a member of the D subfamily of semaphorin receptors. Plexin-D1 is amongst others the receptor for semaphorin 3E (Sema3E) which is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 plays an important role in cell-cell signaling and in regulating the migration of a wide spectrum of cell types, and is able to trigger R-Ras inactivation, leading to axonal and cell repulsion in vitro. Moreover, it was shown that Sema3E mediates either axonal attraction or repulsion in distinct neuronal populations, depending on the coexpression of neuropilin-1 with plexin-D1. Plexin-D1 expression is generally low in normal adult tissues, it is elevated in endothelial cells of tumor vessels and in cancer cells. Additional information: It displays negligible binding to Fc receptors.

Reactivity

Human

Host

Human

Conjugate

Yellow dye

Isotype

IgG

Antibody clone number

SFB653

Vial size

for 100 tests

Storage

Store protected from light at 2ÿ8 °C. Do not freeze.