Explore
Validate
LearnAF2297
antibody from R&D Systems
Targeting: IL36A
FIL1, FIL1E, IL-1F6, IL1(EPSILON), IL1F6, MGC129552, MGC129553
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- AF2297 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-36 alpha/IL-1F6 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Detects mouse IL-36 alpha/IL-1F6 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 5% cross-reactivity with recombinant human (rh) IL-1F5, rhIL-1F6, and rhIL-1F9 is observed, and less than 2% cross-reactivity with recombinant mouse IL-1F8, rhIL-1F7, rhIL-1 alpha , rhIL-1 beta , rhIL-1ra, and rhIL-18 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
Q9JLA2- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Disrupting the IL-36 and IL-23/IL-17 loop underlies the efficacy of calcipotriol and corticosteroid therapy for psoriasis.
Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions.
Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.
IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.
Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Germán B, Wei R, Hener P, Martins C, Ye T, Gottwick C, Yang J, Seneschal J, Boniface K, Li M
JCI insight 2019 Jan 24;4(2)
JCI insight 2019 Jan 24;4(2)
Local CD34-positive capillaries decrease in mouse models of kidney disease associating with the severity of glomerular and tubulointerstitial lesions.
Masum MA, Ichii O, Elewa YHA, Nakamura T, Kon Y
BMC nephrology 2017 Sep 4;18(1):280
BMC nephrology 2017 Sep 4;18(1):280
Interleukin-36 receptor mediates the crosstalk between plasma cells and synovial fibroblasts.
Schmitt V, Hahn M, Kästele V, Wagner O, Wiendl M, Derer A, Taddeo A, Hahne S, Radbruch A, Jäck HM, Schuh W, Mielenz D, Gay S, Schett G, Hueber AJ, Frey S
European journal of immunology 2017 Dec;47(12):2101-2112
European journal of immunology 2017 Dec;47(12):2101-2112
IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.
Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 15;186(4):2613-22
Journal of immunology (Baltimore, Md. : 1950) 2011 Feb 15;186(4):2613-22
Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
Journal of immunology (Baltimore, Md. : 1950) 2009 Sep 15;183(6):4021-30
Journal of immunology (Baltimore, Md. : 1950) 2009 Sep 15;183(6):4021-30
No comments: Submit comment
No validations: Submit validation data