Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS7893 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- ITGB3BP polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human ITGB3BP.
- Description
- CENP-R (centromere protein R), also known as CENPR, ITGB3BP (Integrin ÉÇ3 binding protein), ÉÇ3-endonexin, NRIF3 (nuclear receptor-interacting factor 3) or TAP20, is a widely expressed protein that contains a DD1 or RepD1 domain and an LXXLL motif. Induced by estrogen, CENP-R is believed to function as a nuclear receptor coactivator. It also associates with the CENP-A-CAD complex which is involved in mitotic progression, the assembly of kinetochore proteins and chromosome segregation. A number of isoforms exist for CENP-R due to alternative splicing events. Isoform 1 localizes to the nucleus at the centromere; isoform 2, also known as EnL, En-L or long isoform, localizes to the nucleus; isoform 3, also known as EnS, En-S or short isoform, localizes predominantly to the nucleus but can also be found in the cytoplasm; and isoform 4 predominantly localizes to the cytoplasm. Isoform 3 of CENP-R binds to the cytoplasmic tail of Integrin ÉÇ3 and can activate Integrin Ï«IIb/ÉÇ3.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of ITGB3BP polyclonal antibody