BS7184

antibody from Bioworld Technology, Inc
Targeting: LEPR CD295, OBR
Provider product page for BS7184
Western blot
Immunohistochemistry

Antibody data

Product number
BS7184 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Ob R polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human Ob-R.
Description
The first such recessive obesity mutation, the obese mutation (Ob), was identified in 1950. Mutation of Ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. It has been postulated that the Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The cloning and sequence analysis of the mouse Ob gene and its human homolog has recently been described. Ob encodes an adipose tissue-specific mRNA with a highly conserved 167 amino acid open reading frame. The predicted amino acid sequence is 84% identical between human and mouse and has the features of a secreted protein. A nonsense mutation in codon 105 has been found in the original congenic C57BL/6J Ob/Ob mouse strain. The Ob gene encodes the protein leptin.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
LEPR protein structure - BS7184 shown in red.