Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MAB659-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human Activin B beta B subunit Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human Activin B beta B subunit in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human (rh) Inhibin B or rhActivin A is observed. In Western blots, approximately 20% cross-reactivity with rhInhibin B is observed and no cross-reactivity with rhActivin A or recombinant mouse Activin A is observed.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
Q53T31
- Isotype
- IgG
- Antibody clone number
- 146807
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia.
The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases.
Dussiot M, Maciel TT, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, Leboulch P, Ribeil JA, Arlet JB, Coté F, Courtois G, Ginzburg YZ, Daniel TO, Chopra R, Sung V, Hermine O, Moura IC
Nature medicine 2014 Apr;20(4):398-407
Nature medicine 2014 Apr;20(4):398-407
The neuroprotective effect of Activin A and B: implication for neurodegenerative diseases.
Kupershmidt L, Amit T, Bar-Am O, Youdim MB, Blumenfeld Z
Journal of neurochemistry 2007 Nov;103(3):962-71
Journal of neurochemistry 2007 Nov;103(3):962-71
No comments: Submit comment
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Hemoglobin Expression Induced by Activin B and Neutralization by Human Activin B Antibody. Recombinant Human Activin B beta B subunit (Catalog # 659-AB) increases hemoglobin expression in the K562 human chronic myelogenous leukemia cell line in a dose-dependent manner (orange line), as measured by the psuedoperoxidase assay. Hemoglobin expression elicited by Recombinant Human Activin B beta B subunit (7.5 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-Human Activin B beta B subunit Monoclonal Antibody (Catalog # MAB659). The ND50 is typically 0.6-3.0 µg/mL.