Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
- Flow cytometry [1]
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Validation data
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- Product number
- 10-4030 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-IL-23R Antibody
- Antibody type
- Monoclonal
- Description
- IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A partial length recombinant protei
n (a.a 250-450) of IL-23R was used
as the immunogen for this antibody
.- Isotype
- IgG
- Antibody clone number
- ABM25G4
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of IL-23R. Anti-IL-23R antibody (Clone: ABM25G4) was used at 1 µg/ml on (1) MCF-7, (2) THP1 and (3) A431 lysates.
- Protocol
- Protocol
Supportive validation
- Submitted by
- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Cell surface flow analysis of Anti-IL-23R antibody in K562 cell line using 2 µg/10^6 Cells of Anti-IL23R antibody (Clone: ABM25G4). Green represent Isotype control and red represent Anti-IL23R antibody (10-4030 Abeomics). Goat Anti-mouse PE conjugated was used as the secondary antibody.
- Protocol
- Protocol