DCABH-4187

antibody from Creative Diagnostics

Targeting: PIK3CB PIK3C1

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

DCABH-4187

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-4187, RRID:AB_2477982

Product name

Rabbit Anti-Human PIK3CB monoclonal antibody, clone TD1691

Antibody type

Monoclonal

Description

Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85Ï« and p85ÉÇ), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110Ï« and p110ÉÇ interact with p85Ï«, and p110Ï« has also been shown to interact with p85ÉÇ in vitro. p110 expression is restricted to white blood cells. It has been shown to bind p85Ï« and ÉÇ, but it apparently does not phosphorylate these subunits. p110Ñ´ seems to have the capacity to autophosphorylate. p110ÎÛ does not interact with the p85 subunits. It has been shown to be activated by Ï« and ÉÇ ÎÛ heterotrimeric G proteins.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

TD1691

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.