CABT-B9290

antibody from Creative Diagnostics

Targeting: PIK3CB PIK3C1

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B9290

Provider

Creative Diagnostics

Product name

Mouse anti-Human PI3-Kinase monoclonal antibody, clone 5

Antibody type

Monoclonal

Description

PI3-kinase phosphorylates the D-3 position of the inositol ring of phosphatidylinositol (PtdIns), PtdIns(4)P and PtdIns(4, 5)P2 to produce the respective PI3-phosphorylated derivatives. PI3-kinase exists as a heterodimer of 85 kDa (p85) and 110 kDa (p110) subunits. The p85 subunit contains two SH2 domains and an SH3 domain. It associates with and serves as a substrate for activated growth factor receptor tyrosine kinases. p85 may serve as regulator of the catalytic subunit, p110, by acting as the link between PI3-kinase and the ligand-activated receptor. Two distinct forms of the p85 subunit have been described: 1) p85Ï«, which binds tightly to the catalytic subunit, and 2) p85ÉÇ, a protein whose function is presently unknown. Both isoforms bind to activated receptors and serve as tyrosine kinase substrates.

Reactivity

Human, Mouse, Rat, Canine, Chicken/Avian

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

5

Vial size

50ug, 150ug

Concentration

250 Ã×g/ml

Storage

Store undiluted at -20°C.