CABT-BL8203

antibody from Creative Diagnostics

Targeting: PRNP AltPrP, CD230, CJD, GSS, PRIP, PRP

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8203

Provider

Creative Diagnostics

Product name

Anti-PRNP Monoclonal antibody, clone 5E6

Antibody type

Monoclonal

Description

Cellular prion protein (PrPC) is a highly conserved, 33-35 kDa protease-sensitive, sialoglycoprotein of unknown function which is endogenously expressed in brain. Studies have shown this protein to be anchored to the external surface of the cell membrane by glycosyl phosphatidylinositol. A post-translationally altered, protease-resistant PrPC isoform ( PrP-Scrapie or PrPSc) of 27-30 kDa is found in association with several fatal neurodegenerative disorders collectively termed transmissible spongiform encephalopathies (TSEs). Deposition of PrPSc in the central nervous system is a reliable indication of a TSE. Prion diseases include scrapie in sheep and goats, bovine spongiform encephalopathy or ""Mad Cow disease"", and chronic wasting disease (CWD) in deer and elk. PrP is responsible for Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler-Scheinker (GSS) disease, Fatal Familial Insomnia (FFI), and Kuru in humans.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG