Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [106]
- Comments [0]
- Validations
- Western blot [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- A010-12 - Provider product page
- Provider
- Badrilla Ltd
- Proper citation
- Badrilla Cat#A010-12, RRID:AB_2617047
- Product name
- Phospholamban Phospho Serine-16
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca2+/CaM-dependent (Thr-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure
- Reactivity
- Human, Mouse, Rat, Chicken/Avian, Hamster, Rabbit, Sheep
- Host
- Rabbit
- Antigen sequence
R9SAIRRAS(PO3H2)TIE19Y conjugated t
o KLH- Isotype
- IgG
- Vial size
- 20 µl
- Storage
- Lyophilised: 4 °C Reconstituted:-80 °C
- Handling
- Reconstitute lyophilised powder in 20 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
Submitted references Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.
Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.
Amyloid peptide regulates calcium homoeostasis and arrhythmogenesis in pulmonary vein cardiomyocytes.
Reactive oxygen species contribute to the development of arrhythmogenic Ca²⁺ waves during β-adrenergic receptor stimulation in rabbit cardiomyocytes.
Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity.
Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity.
The impact of rapid atrial pacing on ADMA and endothelial NOS.
Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.
Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.
Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts.
CaMKII inhibition in heart failure, beneficial, harmful, or both.
Influence of taurine on cardiac remodeling induced by tobacco smoke exposure.
Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.
Fatty acid synthase modulates homeostatic responses to myocardial stress.
Exposure to low mercury concentration in vivo impairs myocardial contractile function.
Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.
Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.
Role of reactive oxygen species in the regulation of cardiac contractility.
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A.
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.
Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure.
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats.
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.
Extracellular matrix of collagen modulates intracellular calcium handling and electrophysiological characteristics of HL-1 cardiomyocytes with activation of angiotensin II type 1 receptor.
Regulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activation.
Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality.
FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes.
Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca(2+) cycling.
Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase.
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle.
Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias.
Myocardial transfection with naked DNA plasmid encoding hepatocyte growth factor prevents the progression of heart failure in dogs.
Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes.
Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis.
Superior calcium homeostasis of extraocular muscles.
BNP controls early load-dependent regulation of SERCA through calcineurin.
Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA.
Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure.
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats.
Threonine-5 at the N-terminus can modulate sarcolipin function in cardiac myocytes.
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium.
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium.
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice.
Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism.
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
Positive inotropic effects of epigallocatechin-3-gallate (EGCG) involve activation of Na+/H+ and Na+/Ca2+ exchangers.
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.
Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling.
Compartmentalisation of cAMP-dependent signalling by caveolae in the adult cardiac myocyte.
Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.
Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure.
Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells.
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.
Proteomic studies of PP2A-B56gamma1 phosphatase complexes reveal phosphorylation-regulated partners in cardiac local signaling.
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.
Triadin is a critical determinant of cellular Ca cycling and contractility in the heart.
Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.
Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure.
Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII.
CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.
Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes.
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload.
Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.
Intracellular calcium handling in ventricular myocytes from mdx mice.
Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure.
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure.
Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum.
Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance.
Signaling pathways regulating murine cardiac CREB phosphorylation.
Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells.
Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart.
Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart.
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.
A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1.
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice.
Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.
Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation.
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure.
Frequency-dependent acceleration of relaxation in mammalian heart: a property not relying on phospholamban and SERCA2a phosphorylation.
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice.
Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis.
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration.
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility.
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.
Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, Lakatta EG
PloS one 2012;7(5):e37582
PloS one 2012;7(5):e37582
Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.
Ruiz-Hurtado G, Gómez-Hurtado N, Fernández-Velasco M, Calderón E, Smani T, Ordoñez A, Cachofeiro V, Boscá L, Díez J, Gómez AM, Delgado C
Cardiovascular research 2012 Oct 1;96(1):81-9
Cardiovascular research 2012 Oct 1;96(1):81-9
Amyloid peptide regulates calcium homoeostasis and arrhythmogenesis in pulmonary vein cardiomyocytes.
Tsao HM, Weerateerangkul P, Chen YC, Kao YH, Lin YK, Huang JH, Chen SA, Chen YJ
European journal of clinical investigation 2012 Jun;42(6):589-98
European journal of clinical investigation 2012 Jun;42(6):589-98
Reactive oxygen species contribute to the development of arrhythmogenic Ca²⁺ waves during β-adrenergic receptor stimulation in rabbit cardiomyocytes.
Bovo E, Lipsius SL, Zima AV
The Journal of physiology 2012 Jul 15;590(Pt 14):3291-304
The Journal of physiology 2012 Jul 15;590(Pt 14):3291-304
Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity.
Thireau J, Karam S, Fauconnier J, Roberge S, Cassan C, Cazorla O, Aimond F, Lacampagne A, Babuty D, Richard S
Cardiovascular research 2012 Jul 1;95(1):59-68
Cardiovascular research 2012 Jul 1;95(1):59-68
Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity.
Jiao Q, Takeshima H, Ishikawa Y, Minamisawa S
Cell calcium 2012 Jan;51(1):31-9
Cell calcium 2012 Jan;51(1):31-9
The impact of rapid atrial pacing on ADMA and endothelial NOS.
Goette A, Hammwöhner M, Bukowska A, Scalera F, Martens-Lobenhoffer J, Dobrev D, Ravens U, Weinert S, Medunjanin S, Lendeckel U, Bode-Böger SM
International journal of cardiology 2012 Jan 26;154(2):141-6
International journal of cardiology 2012 Jan 26;154(2):141-6
Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.
Kalyanasundaram A, Viatchenko-Karpinski S, Belevych AE, Lacombe VA, Hwang HS, Knollmann BC, Gyorke S, Periasamy M
American journal of physiology. Heart and circulatory physiology 2012 Jan 1;302(1):H253-61
American journal of physiology. Heart and circulatory physiology 2012 Jan 1;302(1):H253-61
Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte.
Macdougall DA, Agarwal SR, Stopford EA, Chu H, Collins JA, Longster AL, Colyer J, Harvey RD, Calaghan S
Journal of molecular and cellular cardiology 2012 Feb;52(2):388-400
Journal of molecular and cellular cardiology 2012 Feb;52(2):388-400
Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts.
Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6578-83
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6578-83
CaMKII inhibition in heart failure, beneficial, harmful, or both.
Cheng J, Xu L, Lai D, Guilbert A, Lim HJ, Keskanokwong T, Wang Y
American journal of physiology. Heart and circulatory physiology 2012 Apr 1;302(7):H1454-65
American journal of physiology. Heart and circulatory physiology 2012 Apr 1;302(7):H1454-65
Influence of taurine on cardiac remodeling induced by tobacco smoke exposure.
Denipote F, Ardisson LP, Azevedo PS, Minicucci MF, Lima-Leopoldo AP, Chiuso-Minicucci F, Polegato BF, Matsubara BB, Matsubara LS, Novelli E, Paiva SA, Zornoff LA
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(3-4):291-8
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2011;27(3-4):291-8
Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.
Yao L, Fan P, Jiang Z, Viatchenko-Karpinski S, Wu Y, Kornyeyev D, Hirakawa R, Budas GR, Rajamani S, Shryock JC, Belardinelli L
American journal of physiology. Cell physiology 2011 Sep;301(3):C577-86
American journal of physiology. Cell physiology 2011 Sep;301(3):C577-86
Fatty acid synthase modulates homeostatic responses to myocardial stress.
Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW 2nd, Nichols CG, Semenkovich CF
The Journal of biological chemistry 2011 Sep 2;286(35):30949-30961
The Journal of biological chemistry 2011 Sep 2;286(35):30949-30961
Exposure to low mercury concentration in vivo impairs myocardial contractile function.
Furieri LB, Fioresi M, Junior RF, Bartolomé MV, Fernandes AA, Cachofeiro V, Lahera V, Salaices M, Stefanon I, Vassallo DV
Toxicology and applied pharmacology 2011 Sep 1;255(2):193-9
Toxicology and applied pharmacology 2011 Sep 1;255(2):193-9
Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.
Roof SR, Shannon TR, Janssen PM, Ziolo MT
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1570-8
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1570-8
Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.
André L, Gouzi F, Thireau J, Meyer G, Boissiere J, Delage M, Abdellaoui A, Feillet-Coudray C, Fouret G, Cristol JP, Lacampagne A, Obert P, Reboul C, Fauconnier J, Hayot M, Richard S, Cazorla O
Basic research in cardiology 2011 Nov;106(6):1235-46
Basic research in cardiology 2011 Nov;106(6):1235-46
Role of reactive oxygen species in the regulation of cardiac contractility.
Kubin AM, Skoumal R, Tavi P, Kónyi A, Perjés A, Leskinen H, Ruskoaho H, Szokodi I
Journal of molecular and cellular cardiology 2011 May;50(5):884-93
Journal of molecular and cellular cardiology 2011 May;50(5):884-93
Full-length cardiac Na+/Ca2+ exchanger 1 protein is not phosphorylated by protein kinase A.
Wanichawan P, Louch WE, Hortemo KH, Austbø B, Lunde PK, Scott JD, Sejersted OM, Carlson CR
American journal of physiology. Cell physiology 2011 May;300(5):C989-97
American journal of physiology. Cell physiology 2011 May;300(5):C989-97
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K
Circulation 2011 May 24;123(20):2192-203
Circulation 2011 May 24;123(20):2192-203
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR
Journal of molecular and cellular cardiology 2011 Mar;50(3):460-70
Journal of molecular and cellular cardiology 2011 Mar;50(3):460-70
Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice.
van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH
Circulation 2011 Mar 8;123(9):979-88
Circulation 2011 Mar 8;123(9):979-88
Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.
Ferreira JC, Moreira JB, Campos JC, Pereira MG, Mattos KC, Coelho MA, Brum PC
Life sciences 2011 Mar 28;88(13-14):578-85
Life sciences 2011 Mar 28;88(13-14):578-85
Impaired β-adrenergic responsiveness accentuates dysfunctional excitation-contraction coupling in an ovine model of tachypacing-induced heart failure.
Briston SJ, Caldwell JL, Horn MA, Clarke JD, Richards MA, Greensmith DJ, Graham HK, Hall MC, Eisner DA, Dibb KM, Trafford AW
The Journal of physiology 2011 Mar 15;589(Pt 6):1367-82
The Journal of physiology 2011 Mar 15;589(Pt 6):1367-82
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats.
Mostarda C, Moraes-Silva IC, Moreira ED, Medeiros A, Piratello AC, Consolim-Colombo FM, Caldini EG, Brum PC, Krieger EM, Irigoyen MC
Journal of cardiac failure 2011 Jun;17(6):519-25
Journal of cardiac failure 2011 Jun;17(6):519-25
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.
Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM
Journal of molecular and cellular cardiology 2011 Jan;50(1):230-8
Journal of molecular and cellular cardiology 2011 Jan;50(1):230-8
Extracellular matrix of collagen modulates intracellular calcium handling and electrophysiological characteristics of HL-1 cardiomyocytes with activation of angiotensin II type 1 receptor.
Lu YY, Chen YC, Kao YH, Wu TJ, Chen SA, Chen YJ
Journal of cardiac failure 2011 Jan;17(1):82-90
Journal of cardiac failure 2011 Jan;17(1):82-90
Regulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activation.
Haworth RS, Cuello F, Avkiran M
Basic research in cardiology 2011 Jan;106(1):51-63
Basic research in cardiology 2011 Jan;106(1):51-63
Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality.
Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH, Kockskämper J, Priori SG, Pieske B, Maier LS
Journal of the American College of Cardiology 2011 Jan 25;57(4):469-79
Journal of the American College of Cardiology 2011 Jan 25;57(4):469-79
FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes.
Liu S, Zhang J, Xiang YK
Biochemical and biophysical research communications 2011 Jan 14;404(2):581-6
Biochemical and biophysical research communications 2011 Jan 14;404(2):581-6
Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca(2+) cycling.
Aoyama H, Ikeda Y, Miyazaki Y, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M
Cardiovascular research 2011 Jan 1;89(1):79-88
Cardiovascular research 2011 Jan 1;89(1):79-88
Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase.
El-Armouche A, Wittköpper K, Fuller W, Howie J, Shattock MJ, Pavlovic D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Dec;25(12):4467-75
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Dec;25(12):4467-75
Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle.
Sjåland C, Lunde PK, Swift F, Munkvik M, Ericsson M, Lunde M, Boye S, Christensen G, Ellingsen Ø, Sejersted OM, Andersson KB
The Journal of physiology 2011 Dec 15;589(Pt 24):6139-55
The Journal of physiology 2011 Dec 15;589(Pt 24):6139-55
Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias.
Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton KU
Circulation 2011 Dec 13;124(24):2690-701
Circulation 2011 Dec 13;124(24):2690-701
Myocardial transfection with naked DNA plasmid encoding hepatocyte growth factor prevents the progression of heart failure in dogs.
Rastogi S, Guerrero M, Wang M, Ilsar I, Sabbah MS, Gupta RC, Sabbah HN
American journal of physiology. Heart and circulatory physiology 2011 Apr;300(4):H1501-9
American journal of physiology. Heart and circulatory physiology 2011 Apr;300(4):H1501-9
Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Rodrigues B, Rosa KT, Medeiros A, Schaan BD, Brum PC, De Angelis K, Irigoyen MC
Cardiovascular diabetology 2011 Apr 6;10:26
Cardiovascular diabetology 2011 Apr 6;10:26
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes.
De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK
Molecular pharmacology 2010 Sep;78(3):340-9
Molecular pharmacology 2010 Sep;78(3):340-9
Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis.
Bougaki M, Searles RJ, Kida K, Yu J, Buys ES, Ichinose F
Shock (Augusta, Ga.) 2010 Sep;34(3):281-90
Shock (Augusta, Ga.) 2010 Sep;34(3):281-90
Superior calcium homeostasis of extraocular muscles.
Zeiger U, Mitchell CH, Khurana TS
Experimental eye research 2010 Nov;91(5):613-22
Experimental eye research 2010 Nov;91(5):613-22
BNP controls early load-dependent regulation of SERCA through calcineurin.
Toischer K, Teucher N, Unsöld B, Kuhn M, Kögler H, Hasenfuss G
Basic research in cardiology 2010 Nov;105(6):795-804
Basic research in cardiology 2010 Nov;105(6):795-804
Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA.
Stuenaes JT, Bolling A, Ingvaldsen A, Rommundstad C, Sudar E, Lin FC, Lai YC, Jensen J
British journal of pharmacology 2010 May;160(1):116-29
British journal of pharmacology 2010 May;160(1):116-29
Soybean oil increases SERCA2a expression and left ventricular contractility in rats without change in arterial blood pressure.
Ribeiro Junior RF, Fernandes AA, Meira EF, Batista PR, Siman FD, Vassallo DV, Padilha AS, Stefanon I
Lipids in health and disease 2010 May 26;9:53
Lipids in health and disease 2010 May 26;9:53
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T
The Journal of clinical investigation 2010 Jul;120(7):2280-91
The Journal of clinical investigation 2010 Jul;120(7):2280-91
Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats.
Bupha-Intr T, Laosiripisan J, Wattanapermpool J
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Oct;107(4):1105-12
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Oct;107(4):1105-12
Threonine-5 at the N-terminus can modulate sarcolipin function in cardiac myocytes.
Bhupathy P, Babu GJ, Ito M, Periasamy M
Journal of molecular and cellular cardiology 2009 Nov;47(5):723-9
Journal of molecular and cellular cardiology 2009 Nov;47(5):723-9
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH
The Journal of clinical investigation 2009 May;119(5):1230-40
The Journal of clinical investigation 2009 May;119(5):1230-40
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U
Journal of molecular and cellular cardiology 2009 Mar;46(3):385-94
Journal of molecular and cellular cardiology 2009 Mar;46(3):385-94
Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium.
Quaile MP, Kubo H, Kimbrough CL, Douglas SA, Margulies KB
Circulation. Heart failure 2009 Jan;2(1):39-46
Circulation. Heart failure 2009 Jan;2(1):39-46
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV
The Journal of biological chemistry 2009 Jan 16;284(3):1514-22
The Journal of biological chemistry 2009 Jan 16;284(3):1514-22
Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium.
Gergs U, Neumann J, Simm A, Silber RE, Remmers FO, Läer S
Naunyn-Schmiedeberg's archives of pharmacology 2009 Apr;379(4):349-59
Naunyn-Schmiedeberg's archives of pharmacology 2009 Apr;379(4):349-59
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice.
Mørk HK, Sjaastad I, Sejersted OM, Louch WE
American journal of physiology. Heart and circulatory physiology 2009 Apr;296(4):H1069-79
American journal of physiology. Heart and circulatory physiology 2009 Apr;296(4):H1069-79
Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.
Lester WC, Schroder EA, Burgess DE, Yozwiak D, Andres DA, Satin J
Cell calcium 2008 Oct;44(4):353-62
Cell calcium 2008 Oct;44(4):353-62
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Said M, Becerra R, Palomeque J, Rinaldi G, Kaetzel MA, Diaz-Sylvester PL, Copello JA, Dedman JR, Mundiña-Weilenmann C, Vittone L, Mattiazzi A
American journal of physiology. Heart and circulatory physiology 2008 Oct;295(4):H1669-83
American journal of physiology. Heart and circulatory physiology 2008 Oct;295(4):H1669-83
The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism.
Angelone T, Quintieri AM, Brar BK, Limchaiyawat PT, Tota B, Mahata SK, Cerra MC
Endocrinology 2008 Oct;149(10):4780-93
Endocrinology 2008 Oct;149(10):4780-93
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.
Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjønsberg OH, Christensen G
Cardiovascular research 2008 Oct 1;80(1):47-54
Cardiovascular research 2008 Oct 1;80(1):47-54
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.
Huke S, Bers DM
Biochemical and biophysical research communications 2008 Nov 7;376(1):80-5
Biochemical and biophysical research communications 2008 Nov 7;376(1):80-5
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK
The Journal of biological chemistry 2008 Nov 28;283(48):33527-35
The Journal of biological chemistry 2008 Nov 28;283(48):33527-35
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
Prasad V, Bodi I, Meyer JW, Wang Y, Ashraf M, Engle SJ, Doetschman T, Sisco K, Nieman ML, Miller ML, Lorenz JN, Shull GE
The Journal of biological chemistry 2008 Nov 14;283(46):31303-14
The Journal of biological chemistry 2008 Nov 14;283(46):31303-14
Positive inotropic effects of epigallocatechin-3-gallate (EGCG) involve activation of Na+/H+ and Na+/Ca2+ exchangers.
Lorenz M, Hellige N, Rieder P, Kinkel HT, Trimpert C, Staudt A, Felix SB, Baumann G, Stangl K, Stangl V
European journal of heart failure 2008 May;10(5):439-45
European journal of heart failure 2008 May;10(5):439-45
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.
Wang H, Kohr MJ, Traynham CJ, Wheeler DG, Janssen PM, Ziolo MT
American journal of physiology. Cell physiology 2008 Jun;294(6):C1566-75
American journal of physiology. Cell physiology 2008 Jun;294(6):C1566-75
Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling.
Loyer X, Gómez AM, Milliez P, Fernandez-Velasco M, Vangheluwe P, Vinet L, Charue D, Vaudin E, Zhang W, Sainte-Marie Y, Robidel E, Marty I, Mayer B, Jaisser F, Mercadier JJ, Richard S, Shah AM, Bénitah JP, Samuel JL, Heymes C
Circulation 2008 Jun 24;117(25):3187-98
Circulation 2008 Jun 24;117(25):3187-98
Compartmentalisation of cAMP-dependent signalling by caveolae in the adult cardiac myocyte.
Calaghan S, Kozera L, White E
Journal of molecular and cellular cardiology 2008 Jul;45(1):88-92
Journal of molecular and cellular cardiology 2008 Jul;45(1):88-92
Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.
Medeiros A, Rolim NP, Oliveira RS, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC
Journal of applied physiology (Bethesda, Md. : 1985) 2008 Jan;104(1):103-9
Journal of applied physiology (Bethesda, Md. : 1985) 2008 Jan;104(1):103-9
Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure.
Bartholomeu JB, Vanzelli AS, Rolim NP, Ferreira JC, Bechara LR, Tanaka LY, Rosa KT, Alves MM, Medeiros A, Mattos KC, Coelho MA, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Ramires PR, Guatimosim S, Brum PC
Journal of molecular and cellular cardiology 2008 Aug;45(2):240-9
Journal of molecular and cellular cardiology 2008 Aug;45(2):240-9
Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells.
Manni S, Mauban JH, Ward CW, Bond M
The Journal of biological chemistry 2008 Aug 29;283(35):24145-54
The Journal of biological chemistry 2008 Aug 29;283(35):24145-54
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Grote-Wessels S, Baba HA, Boknik P, El-Armouche A, Fabritz L, Gillmann HJ, Kucerova D, Matus M, Müller FU, Neumann J, Schmitz M, Stümpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U
Cardiovascular research 2008 Aug 1;79(3):464-71
Cardiovascular research 2008 Aug 1;79(3):464-71
Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases.
Vinogradova TM, Sirenko S, Lyashkov AE, Younes A, Li Y, Zhu W, Yang D, Ruknudin AM, Spurgeon H, Lakatta EG
Circulation research 2008 Apr 11;102(7):761-9
Circulation research 2008 Apr 11;102(7):761-9
Proteomic studies of PP2A-B56gamma1 phosphatase complexes reveal phosphorylation-regulated partners in cardiac local signaling.
Zhou XW, Mudannayake M, Green M, Gigena MS, Wang G, Shen RF, Rogers TB
Journal of proteome research 2007 Sep;6(9):3433-42
Journal of proteome research 2007 Sep;6(9):3433-42
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Birkeland JA, Swift F, Tovsrud N, Enger U, Lunde PK, Qvigstad E, Levy FO, Sejersted OM, Sjaastad I
American journal of physiology. Heart and circulatory physiology 2007 Oct;293(4):H2367-76
American journal of physiology. Heart and circulatory physiology 2007 Oct;293(4):H2367-76
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.
Quaile MP, Rossman EI, Berretta RM, Bratinov G, Kubo H, Houser SR, Margulies KB
Journal of molecular and cellular cardiology 2007 Nov;43(5):552-63
Journal of molecular and cellular cardiology 2007 Nov;43(5):552-63
Triadin is a critical determinant of cellular Ca cycling and contractility in the heart.
Kirchhefer U, Klimas J, Baba HA, Buchwalow IB, Fabritz L, Hüls M, Matus M, Müller FU, Schmitz W, Neumann J
American journal of physiology. Heart and circulatory physiology 2007 Nov;293(5):H3165-74
American journal of physiology. Heart and circulatory physiology 2007 Nov;293(5):H3165-74
Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.
MacDonnell SM, Kubo H, Harris DM, Chen X, Berretta R, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR
American journal of physiology. Heart and circulatory physiology 2007 Nov;293(5):H3122-9
American journal of physiology. Heart and circulatory physiology 2007 Nov;293(5):H3122-9
Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure.
Rolim NP, Medeiros A, Rosa KT, Mattos KC, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC
Physiological genomics 2007 May 11;29(3):246-52
Physiological genomics 2007 May 11;29(3):246-52
Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.
Grimm M, El-Armouche A, Zhang R, Anderson ME, Eschenhagen T
Journal of molecular and cellular cardiology 2007 Mar;42(3):643-52
Journal of molecular and cellular cardiology 2007 Mar;42(3):643-52
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII.
Huke S, Bers DM
Journal of molecular and cellular cardiology 2007 Mar;42(3):590-9
Journal of molecular and cellular cardiology 2007 Mar;42(3):590-9
CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.
Vila-Petroff M, Salas MA, Said M, Valverde CA, Sapia L, Portiansky E, Hajjar RJ, Kranias EG, Mundiña-Weilenmann C, Mattiazzi A
Cardiovascular research 2007 Mar 1;73(4):689-98
Cardiovascular research 2007 Mar 1;73(4):689-98
Phosphorylation of human inhibitor-1 at Ser67 and/or Thr75 attenuates stimulatory effects of protein kinase A signaling in cardiac myocytes.
Rodriguez P, Mitton B, Nicolaou P, Chen G, Kranias EG
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H762-9
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H762-9
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload.
Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H620-7
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H620-7
Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.
Song L, Alcalai R, Arad M, Wolf CM, Toka O, Conner DA, Berul CI, Eldar M, Seidman CE, Seidman JG
The Journal of clinical investigation 2007 Jul;117(7):1814-23
The Journal of clinical investigation 2007 Jul;117(7):1814-23
Intracellular calcium handling in ventricular myocytes from mdx mice.
Williams IA, Allen DG
American journal of physiology. Heart and circulatory physiology 2007 Feb;292(2):H846-55
American journal of physiology. Heart and circulatory physiology 2007 Feb;292(2):H846-55
Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure.
El-Armouche A, Pohlmann L, Schlossarek S, Starbatty J, Yeh YH, Nattel S, Dobrev D, Eschenhagen T, Carrier L
Journal of molecular and cellular cardiology 2007 Aug;43(2):223-9
Journal of molecular and cellular cardiology 2007 Aug;43(2):223-9
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure.
Mørk HK, Sjaastad I, Sande JB, Periasamy M, Sejersted OM, Louch WE
Journal of molecular and cellular cardiology 2007 Aug;43(2):177-86
Journal of molecular and cellular cardiology 2007 Aug;43(2):177-86
Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum.
Bupha-Intr T, Wattanapermpool J
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1101-8
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1101-8
Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance.
Vasanji Z, Cantor EJ, Juric D, Moyen M, Netticadan T
American journal of physiology. Cell physiology 2006 Oct;291(4):C772-80
American journal of physiology. Cell physiology 2006 Oct;291(4):C772-80
Signaling pathways regulating murine cardiac CREB phosphorylation.
Li B, Kaetzel MA, Dedman JR
Biochemical and biophysical research communications 2006 Nov 10;350(1):179-84
Biochemical and biophysical research communications 2006 Nov 10;350(1):179-84
Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells.
Rueda A, Song M, Toro L, Stefani E, Valdivia HH
The Journal of physiology 2006 Nov 1;576(Pt 3):887-901
The Journal of physiology 2006 Nov 1;576(Pt 3):887-901
Down regulation of the L-type Ca2+ channel, GRK2, and phosphorylated phospholamban: protective mechanisms for the denervated failing heart.
Yatani A, Shen YT, Yan L, Chen W, Kim SJ, Sano K, Irie K, Vatner SF, Vatner DE
Journal of molecular and cellular cardiology 2006 May;40(5):619-28
Journal of molecular and cellular cardiology 2006 May;40(5):619-28
Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart.
Valverde CA, Mundiña-Weilenmann C, Reyes M, Kranias EG, Escobar AL, Mattiazzi A
Cardiovascular research 2006 May 1;70(2):335-45
Cardiovascular research 2006 May 1;70(2):335-45
High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells.
Vinogradova TM, Lyashkov AE, Zhu W, Ruknudin AM, Sirenko S, Yang D, Deo S, Barlow M, Johnson S, Caffrey JL, Zhou YY, Xiao RP, Cheng H, Stern MD, Maltsev VA, Lakatta EG
Circulation research 2006 Mar 3;98(4):505-14
Circulation research 2006 Mar 3;98(4):505-14
A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1.
Snabaitis AK, D'Mello R, Dashnyam S, Avkiran M
The Journal of biological chemistry 2006 Jul 21;281(29):20252-62
The Journal of biological chemistry 2006 Jul 21;281(29):20252-62
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 17;103(3):511-8
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 17;103(3):511-8
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice.
Larsen KO, Sjaastad I, Svindland A, Krobert KA, Skjønsberg OH, Christensen G
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H507-16
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H507-16
Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes.
El-Armouche A, Bednorz A, Pamminger T, Ditz D, Didié M, Dobrev D, Eschenhagen T
Biochemical and biophysical research communications 2006 Aug 4;346(3):700-6
Biochemical and biophysical research communications 2006 Aug 4;346(3):700-6
Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation.
Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schröder E, Wait R, Begum S, Kentish JC, Eaton P
The Journal of biological chemistry 2006 Aug 4;281(31):21827-36
The Journal of biological chemistry 2006 Aug 4;281(31):21827-36
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR Jr, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J Jr, Chen J, Xiao RP, Cheng H, Fu XD
Cell 2005 Jan 14;120(1):59-72
Cell 2005 Jan 14;120(1):59-72
Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure.
Mishra S, Sabbah HN, Rastogi S, Imai M, Gupta RC
Heart and vessels 2005 Feb;20(1):23-32
Heart and vessels 2005 Feb;20(1):23-32
Frequency-dependent acceleration of relaxation in mammalian heart: a property not relying on phospholamban and SERCA2a phosphorylation.
Valverde CA, Mundiña-Weilenmann C, Said M, Ferrero P, Vittone L, Salas M, Palomeque J, Petroff MV, Mattiazzi A
The Journal of physiology 2005 Feb 1;562(Pt 3):801-13
The Journal of physiology 2005 Feb 1;562(Pt 3):801-13
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM
Circulation research 2005 Dec 9;97(12):1314-22
Circulation research 2005 Dec 9;97(12):1314-22
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice.
Woldbaek PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T
American journal of physiology. Heart and circulatory physiology 2005 Aug;289(2):H708-14
American journal of physiology. Heart and circulatory physiology 2005 Aug;289(2):H708-14
Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis.
Mundiña-Weilenmann C, Ferrero P, Said M, Vittone L, Kranias EG, Mattiazzi A
Cardiovascular research 2005 Apr 1;66(1):114-22
Cardiovascular research 2005 Apr 1;66(1):114-22
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Jiang M, Xu A, Jones DL, Narayanan N
American journal of physiology. Cell physiology 2004 Sep;287(3):C622-32
American journal of physiology. Cell physiology 2004 Sep;287(3):C622-32
Direct inhibition of type 5 adenylyl cyclase prevents myocardial apoptosis without functional deterioration.
Iwatsubo K, Minamisawa S, Tsunematsu T, Nakagome M, Toya Y, Tomlinson JE, Umemura S, Scarborough RM, Levy DE, Ishikawa Y
The Journal of biological chemistry 2004 Sep 24;279(39):40938-45
The Journal of biological chemistry 2004 Sep 24;279(39):40938-45
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T
The Journal of biological chemistry 2004 May 14;279(20):21383-93
The Journal of biological chemistry 2004 May 14;279(20):21383-93
Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility.
Zhao W, Uehara Y, Chu G, Song Q, Qian J, Young K, Kranias EG
Journal of molecular and cellular cardiology 2004 Aug;37(2):607-12
Journal of molecular and cellular cardiology 2004 Aug;37(2):607-12
Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.
Zhu WZ, Wang SQ, Chakir K, Yang D, Zhang T, Brown JH, Devic E, Kobilka BK, Cheng H, Xiao RP
The Journal of clinical investigation 2003 Mar;111(5):617-25
The Journal of clinical investigation 2003 Mar;111(5):617-25
Novel regulation of cardiac force-frequency relation by CREM (cAMP response element modulator).
Isoda T, Paolocci N, Haghighi K, Wang C, Wang Y, Georgakopoulos D, Servillo G, Della Fazia MA, Kranias EG, Depaoli-Roach AA, Sassone-Corsi P, Kass DA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Feb;17(2):144-51
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 Feb;17(2):144-51
No comments: Submit comment
Supportive validation
- Submitted by
- Badrilla Ltd (provider)
- Main image
- Experimental details
- Western blot
- Sample type
- Canine sarcoplasmic reticulum +/- PKA or CaMKII treatment (not boiled)
- Validation comment
- Ab stains for PLB monomer and multimer in PKA treated samples, but not unphosphorylated or CaMKII treated
- Primary Ab dilution
- 3.513888889
- Secondary Ab dilution
- 1.430555556
- Protocol
- Protocol
