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- Antibody Data
- Antigen structure
- References [104]
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- Product number
- A010-13 - Provider product page
- Provider
- Badrilla Ltd
- Proper citation
- Badrilla Cat#A010-13, RRID:AB_2617048
- Product name
- Phospholamban Phospho Threonine-17 Anti-Serum
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Description
- Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca2+/CaM-dependent (Thr-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure
- Host
- Rabbit
- Antigen sequence
R9SAIRRAST(PO3H2)IEY20 conjugated t
o KLH.- Isotype
- IgG
- Vial size
- 20 µl
- Storage
- Lyophilised: 4 °C Reconstituted:-80 °C
- Handling
- Reconstitute lyophilised powder in 20 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
Submitted references Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity.
Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling.
Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.
Early apoptosis in different models of cardiac hypertrophy induced by high renin-angiotensin system activity involves CaMKII.
Accurate quantitation of phospholamban phosphorylation by immunoblot.
PICOT increases cardiac contractility by inhibiting PKCζ activity.
Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity.
The impact of rapid atrial pacing on ADMA and endothelial NOS.
Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.
Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness.
PKCβII modulation of myocyte contractile performance.
Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts.
CaMKII inhibition in heart failure, beneficial, harmful, or both.
Fatty acid synthase modulates homeostatic responses to myocardial stress.
Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice.
Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.
Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.
Changes in myofilament proteins, but not Ca²⁺ regulation, are associated with a high-fat diet-induced improvement in contractile function in heart failure.
Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats.
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.
Extracellular matrix of collagen modulates intracellular calcium handling and electrophysiological characteristics of HL-1 cardiomyocytes with activation of angiotensin II type 1 receptor.
Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality.
Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca(2+) cycling.
Aromatase deficiency confers paradoxical postischemic cardioprotection.
Myocardial transfection with naked DNA plasmid encoding hepatocyte growth factor prevents the progression of heart failure in dogs.
Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis.
Immersion before dry simulated dive reduces cardiomyocyte function and increases mortality after decompression.
Superior calcium homeostasis of extraocular muscles.
BNP controls early load-dependent regulation of SERCA through calcineurin.
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate.
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.
Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure.
CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation.
Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats.
Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.
Threonine-5 at the N-terminus can modulate sarcolipin function in cardiac myocytes.
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome.
Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium.
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models.
Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium.
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice.
Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy.
Positive inotropic effects of epigallocatechin-3-gallate (EGCG) involve activation of Na+/H+ and Na+/Ca2+ exchangers.
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.
Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling.
Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.
PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility.
Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure.
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Proteomic studies of PP2A-B56gamma1 phosphatase complexes reveal phosphorylation-regulated partners in cardiac local signaling.
Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban.
Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling.
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.
Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.
Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels.
Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure.
Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII.
CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload.
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure.
Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.
Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis.
Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum.
Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance.
Signaling pathways regulating murine cardiac CREB phosphorylation.
Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart.
Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.
L-arginine administration recovers sarcoplasmic reticulum function in ischemic reperfused hearts by preventing calpain activation.
Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression.
Overexpression of junctin causes adaptive changes in cardiac myocyte Ca(2+) signaling.
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice.
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.
Enhanced cardiac function in mice overexpressing protein phosphatase Inhibitor-2.
Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia.
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure.
Frequency-dependent acceleration of relaxation in mammalian heart: a property not relying on phospholamban and SERCA2a phosphorylation.
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats.
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice.
Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis.
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Cardiac contractile dysfunction in J2N-k cardiomyopathic hamsters is associated with impaired SR function and regulation.
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart.
Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility.
Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev VA, Lakatta EG
PloS one 2012;7(5):e37582
PloS one 2012;7(5):e37582
Heart failure-inducible gene therapy targeting protein phosphatase 1 prevents progressive left ventricular remodeling.
Miyazaki Y, Ikeda Y, Shiraishi K, Fujimoto SN, Aoyama H, Yoshimura K, Inui M, Hoshijima M, Kasahara H, Aoki H, Matsuzaki M
PloS one 2012;7(4):e35875
PloS one 2012;7(4):e35875
Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.
Ruiz-Hurtado G, Gómez-Hurtado N, Fernández-Velasco M, Calderón E, Smani T, Ordoñez A, Cachofeiro V, Boscá L, Díez J, Gómez AM, Delgado C
Cardiovascular research 2012 Oct 1;96(1):81-9
Cardiovascular research 2012 Oct 1;96(1):81-9
Early apoptosis in different models of cardiac hypertrophy induced by high renin-angiotensin system activity involves CaMKII.
Velez Rueda JO, Palomeque J, Mattiazzi A
Journal of applied physiology (Bethesda, Md. : 1985) 2012 Jun;112(12):2110-20
Journal of applied physiology (Bethesda, Md. : 1985) 2012 Jun;112(12):2110-20
Accurate quantitation of phospholamban phosphorylation by immunoblot.
Ablorh NA, Miller T, Nitu F, Gruber SJ, Karim C, Thomas DD
Analytical biochemistry 2012 Jun 1;425(1):68-75
Analytical biochemistry 2012 Jun 1;425(1):68-75
PICOT increases cardiac contractility by inhibiting PKCζ activity.
Oh JG, Jeong D, Cha H, Kim JM, Lifirsu E, Kim J, Yang DK, Park CS, Kho C, Park S, Yoo YJ, Kim do H, Kim J, Hajjar RJ, Park WJ
Journal of molecular and cellular cardiology 2012 Jul;53(1):53-63
Journal of molecular and cellular cardiology 2012 Jul;53(1):53-63
Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity.
Jiao Q, Takeshima H, Ishikawa Y, Minamisawa S
Cell calcium 2012 Jan;51(1):31-9
Cell calcium 2012 Jan;51(1):31-9
The impact of rapid atrial pacing on ADMA and endothelial NOS.
Goette A, Hammwöhner M, Bukowska A, Scalera F, Martens-Lobenhoffer J, Dobrev D, Ravens U, Weinert S, Medunjanin S, Lendeckel U, Bode-Böger SM
International journal of cardiology 2012 Jan 26;154(2):141-6
International journal of cardiology 2012 Jan 26;154(2):141-6
Functional consequences of stably expressing a mutant calsequestrin (CASQ2D307H) in the CASQ2 null background.
Kalyanasundaram A, Viatchenko-Karpinski S, Belevych AE, Lacombe VA, Hwang HS, Knollmann BC, Gyorke S, Periasamy M
American journal of physiology. Heart and circulatory physiology 2012 Jan 1;302(1):H253-61
American journal of physiology. Heart and circulatory physiology 2012 Jan 1;302(1):H253-61
Fructose diet treatment in mice induces fundamental disturbance of cardiomyocyte Ca2+ handling and myofilament responsiveness.
Mellor KM, Wendt IR, Ritchie RH, Delbridge LM
American journal of physiology. Heart and circulatory physiology 2012 Feb 15;302(4):H964-72
American journal of physiology. Heart and circulatory physiology 2012 Feb 15;302(4):H964-72
PKCβII modulation of myocyte contractile performance.
Hwang H, Robinson DA, Stevenson TK, Wu HC, Kampert SE, Pagani FD, Dyke DB, Martin JL, Sadayappan S, Day SM, Westfall MV
Journal of molecular and cellular cardiology 2012 Aug;53(2):176-86
Journal of molecular and cellular cardiology 2012 Aug;53(2):176-86
Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts.
Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6578-83
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 24;109(17):6578-83
CaMKII inhibition in heart failure, beneficial, harmful, or both.
Cheng J, Xu L, Lai D, Guilbert A, Lim HJ, Keskanokwong T, Wang Y
American journal of physiology. Heart and circulatory physiology 2012 Apr 1;302(7):H1454-65
American journal of physiology. Heart and circulatory physiology 2012 Apr 1;302(7):H1454-65
Fatty acid synthase modulates homeostatic responses to myocardial stress.
Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW 2nd, Nichols CG, Semenkovich CF
The Journal of biological chemistry 2011 Sep 2;286(35):30949-30961
The Journal of biological chemistry 2011 Sep 2;286(35):30949-30961
Sex hormone control of left ventricular structure/function: mechanistic insights using echocardiography, expression, and DNA methylation analyses in adult mice.
Sebag IA, Gillis MA, Calderone A, Kasneci A, Meilleur M, Haddad R, Noiles W, Patel B, Chalifour LE
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1706-15
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1706-15
Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N.
Gaffin RD, Chowdhury SA, Alves MS, Dias FA, Ribeiro CT, Fogaca RT, Wieczorek DF, Wolska BM
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1646-55
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1646-55
Effects of increased systolic Ca²⁺ and phospholamban phosphorylation during β-adrenergic stimulation on Ca²⁺ transient kinetics in cardiac myocytes.
Roof SR, Shannon TR, Janssen PM, Ziolo MT
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1570-8
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1570-8
Changes in myofilament proteins, but not Ca²⁺ regulation, are associated with a high-fat diet-induced improvement in contractile function in heart failure.
Cheng Y, Li W, McElfresh TA, Chen X, Berthiaume JM, Castel L, Yu X, Van Wagoner DR, Chandler MP
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1438-46
American journal of physiology. Heart and circulatory physiology 2011 Oct;301(4):H1438-46
Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress.
André L, Gouzi F, Thireau J, Meyer G, Boissiere J, Delage M, Abdellaoui A, Feillet-Coudray C, Fouret G, Cristol JP, Lacampagne A, Obert P, Reboul C, Fauconnier J, Hayot M, Richard S, Cazorla O
Basic research in cardiology 2011 Nov;106(6):1235-46
Basic research in cardiology 2011 Nov;106(6):1235-46
Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K
Circulation 2011 May 24;123(20):2192-203
Circulation 2011 May 24;123(20):2192-203
Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy.
Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR
Journal of molecular and cellular cardiology 2011 Mar;50(3):460-70
Journal of molecular and cellular cardiology 2011 Mar;50(3):460-70
Angiotensin receptor blockade improves the net balance of cardiac Ca(2+) handling-related proteins in sympathetic hyperactivity-induced heart failure.
Ferreira JC, Moreira JB, Campos JC, Pereira MG, Mattos KC, Coelho MA, Brum PC
Life sciences 2011 Mar 28;88(13-14):578-85
Life sciences 2011 Mar 28;88(13-14):578-85
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats.
Mostarda C, Moraes-Silva IC, Moreira ED, Medeiros A, Piratello AC, Consolim-Colombo FM, Caldini EG, Brum PC, Krieger EM, Irigoyen MC
Journal of cardiac failure 2011 Jun;17(6):519-25
Journal of cardiac failure 2011 Jun;17(6):519-25
SR-targeted CaMKII inhibition improves SR Ca²+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC.
Huke S, Desantiago J, Kaetzel MA, Mishra S, Brown JH, Dedman JR, Bers DM
Journal of molecular and cellular cardiology 2011 Jan;50(1):230-8
Journal of molecular and cellular cardiology 2011 Jan;50(1):230-8
Extracellular matrix of collagen modulates intracellular calcium handling and electrophysiological characteristics of HL-1 cardiomyocytes with activation of angiotensin II type 1 receptor.
Lu YY, Chen YC, Kao YH, Wu TJ, Chen SA, Chen YJ
Journal of cardiac failure 2011 Jan;17(1):82-90
Journal of cardiac failure 2011 Jan;17(1):82-90
Overexpression of CaMKIIδc in RyR2R4496C+/- knock-in mice leads to altered intracellular Ca2+ handling and increased mortality.
Dybkova N, Sedej S, Napolitano C, Neef S, Rokita AG, Hünlich M, Brown JH, Kockskämper J, Priori SG, Pieske B, Maier LS
Journal of the American College of Cardiology 2011 Jan 25;57(4):469-79
Journal of the American College of Cardiology 2011 Jan 25;57(4):469-79
Isoform-specific roles of protein phosphatase 1 catalytic subunits in sarcoplasmic reticulum-mediated Ca(2+) cycling.
Aoyama H, Ikeda Y, Miyazaki Y, Yoshimura K, Nishino S, Yamamoto T, Yano M, Inui M, Aoki H, Matsuzaki M
Cardiovascular research 2011 Jan 1;89(1):79-88
Cardiovascular research 2011 Jan 1;89(1):79-88
Aromatase deficiency confers paradoxical postischemic cardioprotection.
Bell JR, Mellor KM, Wollermann AC, Ip WT, Reichelt ME, Meachem SJ, Simpson ER, Delbridge LM
Endocrinology 2011 Dec;152(12):4937-47
Endocrinology 2011 Dec;152(12):4937-47
Myocardial transfection with naked DNA plasmid encoding hepatocyte growth factor prevents the progression of heart failure in dogs.
Rastogi S, Guerrero M, Wang M, Ilsar I, Sabbah MS, Gupta RC, Sabbah HN
American journal of physiology. Heart and circulatory physiology 2011 Apr;300(4):H1501-9
American journal of physiology. Heart and circulatory physiology 2011 Apr;300(4):H1501-9
Hyperglycemia can delay left ventricular dysfunction but not autonomic damage after myocardial infarction in rodents.
Rodrigues B, Rosa KT, Medeiros A, Schaan BD, Brum PC, De Angelis K, Irigoyen MC
Cardiovascular diabetology 2011 Apr 6;10:26
Cardiovascular diabetology 2011 Apr 6;10:26
Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis.
Bougaki M, Searles RJ, Kida K, Yu J, Buys ES, Ichinose F
Shock (Augusta, Ga.) 2010 Sep;34(3):281-90
Shock (Augusta, Ga.) 2010 Sep;34(3):281-90
Immersion before dry simulated dive reduces cardiomyocyte function and increases mortality after decompression.
Gaustad SE, Brubakk AO, Høydal M, Catalucci D, Condorelli G, Dujic Z, Marinovic J, Ljubkovic M, Møllerløkken A, Wisløff U
Journal of applied physiology (Bethesda, Md. : 1985) 2010 Sep;109(3):752-7
Journal of applied physiology (Bethesda, Md. : 1985) 2010 Sep;109(3):752-7
Superior calcium homeostasis of extraocular muscles.
Zeiger U, Mitchell CH, Khurana TS
Experimental eye research 2010 Nov;91(5):613-22
Experimental eye research 2010 Nov;91(5):613-22
BNP controls early load-dependent regulation of SERCA through calcineurin.
Toischer K, Teucher N, Unsöld B, Kuhn M, Kögler H, Hasenfuss G
Basic research in cardiology 2010 Nov;105(6):795-804
Basic research in cardiology 2010 Nov;105(6):795-804
GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.
Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T
The Journal of clinical investigation 2010 Jul;120(7):2280-91
The Journal of clinical investigation 2010 Jul;120(7):2280-91
Cardiomyocytes with disrupted CFTR function require CaMKII and Ca(2+)-activated Cl(-) channel activity to maintain contraction rate.
Sellers ZM, De Arcangelis V, Xiang Y, Best PM
The Journal of physiology 2010 Jul 1;588(Pt 13):2417-29
The Journal of physiology 2010 Jul 1;588(Pt 13):2417-29
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function.
Maillet M, Davis J, Auger-Messier M, York A, Osinska H, Piquereau J, Lorenz JN, Robbins J, Ventura-Clapier R, Molkentin JD
The Journal of biological chemistry 2010 Feb 26;285(9):6716-24
The Journal of biological chemistry 2010 Feb 26;285(9):6716-24
Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure.
Lara A, Damasceno DD, Pires R, Gros R, Gomes ER, Gavioli M, Lima RF, Guimarães D, Lima P, Bueno CR Jr, Vasconcelos A, Roman-Campos D, Menezes CA, Sirvente RA, Salemi VM, Mady C, Caron MG, Ferreira AJ, Brum PC, Resende RR, Cruz JS, Gomez MV, Prado VF, de Almeida AP, Prado MA, Guatimosim S
Molecular and cellular biology 2010 Apr;30(7):1746-56
Molecular and cellular biology 2010 Apr;30(7):1746-56
CaMKII-dependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation.
Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, Seipelt R, Schöndube FA, Hasenfuss G, Maier LS
Circulation research 2010 Apr 2;106(6):1134-44
Circulation research 2010 Apr 2;106(6):1134-44
Moderate intensity of regular exercise improves cardiac SR Ca2+ uptake activity in ovariectomized rats.
Bupha-Intr T, Laosiripisan J, Wattanapermpool J
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Oct;107(4):1105-12
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Oct;107(4):1105-12
Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17.
Catalucci D, Latronico MV, Ceci M, Rusconi F, Young HS, Gallo P, Santonastasi M, Bellacosa A, Brown JH, Condorelli G
The Journal of biological chemistry 2009 Oct 9;284(41):28180-7
The Journal of biological chemistry 2009 Oct 9;284(41):28180-7
Threonine-5 at the N-terminus can modulate sarcolipin function in cardiac myocytes.
Bhupathy P, Babu GJ, Ito M, Periasamy M
Journal of molecular and cellular cardiology 2009 Nov;47(5):723-9
Journal of molecular and cellular cardiology 2009 Nov;47(5):723-9
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH
The Journal of clinical investigation 2009 May;119(5):1230-40
The Journal of clinical investigation 2009 May;119(5):1230-40
Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation.
Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U
Journal of molecular and cellular cardiology 2009 Mar;46(3):385-94
Journal of molecular and cellular cardiology 2009 Mar;46(3):385-94
The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome.
Qi X, Yeh YH, Chartier D, Xiao L, Tsuji Y, Brundel BJ, Kodama I, Nattel S
Circulation. Arrhythmia and electrophysiology 2009 Jun;2(3):295-304
Circulation. Arrhythmia and electrophysiology 2009 Jun;2(3):295-304
Direct inotropic effects of exogenous and endogenous urotensin-II: divergent actions in failing and nonfailing human myocardium.
Quaile MP, Kubo H, Kimbrough CL, Douglas SA, Margulies KB
Circulation. Heart failure 2009 Jan;2(1):39-46
Circulation. Heart failure 2009 Jan;2(1):39-46
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II.
Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV
The Journal of biological chemistry 2009 Jan 16;284(3):1514-22
The Journal of biological chemistry 2009 Jan 16;284(3):1514-22
Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models.
Guinto PJ, Haim TE, Dowell-Martino CC, Sibinga N, Tardiff JC
American journal of physiology. Heart and circulatory physiology 2009 Aug;297(2):H614-26
American journal of physiology. Heart and circulatory physiology 2009 Aug;297(2):H614-26
Phosphorylation of phospholamban and troponin I through 5-HT4 receptors in the isolated human atrium.
Gergs U, Neumann J, Simm A, Silber RE, Remmers FO, Läer S
Naunyn-Schmiedeberg's archives of pharmacology 2009 Apr;379(4):349-59
Naunyn-Schmiedeberg's archives of pharmacology 2009 Apr;379(4):349-59
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice.
Mørk HK, Sjaastad I, Sejersted OM, Louch WE
American journal of physiology. Heart and circulatory physiology 2009 Apr;296(4):H1069-79
American journal of physiology. Heart and circulatory physiology 2009 Apr;296(4):H1069-79
Steady-state coupling of plasma membrane calcium entry to extrusion revealed by novel L-type calcium channel block.
Lester WC, Schroder EA, Burgess DE, Yozwiak D, Andres DA, Satin J
Cell calcium 2008 Oct;44(4):353-62
Cell calcium 2008 Oct;44(4):353-62
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II.
Said M, Becerra R, Palomeque J, Rinaldi G, Kaetzel MA, Diaz-Sylvester PL, Copello JA, Dedman JR, Mundiña-Weilenmann C, Vittone L, Mattiazzi A
American journal of physiology. Heart and circulatory physiology 2008 Oct;295(4):H1669-83
American journal of physiology. Heart and circulatory physiology 2008 Oct;295(4):H1669-83
Diastolic dysfunction in alveolar hypoxia: a role for interleukin-18-mediated increase in protein phosphatase 2A.
Larsen KO, Lygren B, Sjaastad I, Krobert KA, Arnkvaern K, Florholmen G, Larsen AK, Levy FO, Taskén K, Skjønsberg OH, Christensen G
Cardiovascular research 2008 Oct 1;80(1):47-54
Cardiovascular research 2008 Oct 1;80(1):47-54
Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes.
Huke S, Bers DM
Biochemical and biophysical research communications 2008 Nov 7;376(1):80-5
Biochemical and biophysical research communications 2008 Nov 7;376(1):80-5
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes.
Gao MH, Tang T, Guo T, Miyanohara A, Yajima T, Pestonjamasp K, Feramisco JR, Hammond HK
The Journal of biological chemistry 2008 Nov 28;283(48):33527-35
The Journal of biological chemistry 2008 Nov 28;283(48):33527-35
Impaired cardiac contractility in mice lacking both the AE3 Cl-/HCO3- exchanger and the NKCC1 Na+-K+-2Cl- cotransporter: effects on Ca2+ handling and protein phosphatases.
Prasad V, Bodi I, Meyer JW, Wang Y, Ashraf M, Engle SJ, Doetschman T, Sisco K, Nieman ML, Miller ML, Lorenz JN, Shull GE
The Journal of biological chemistry 2008 Nov 14;283(46):31303-14
The Journal of biological chemistry 2008 Nov 14;283(46):31303-14
Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy.
Bye A, Sørhaug S, Ceci M, Høydal MA, Stølen T, Heinrich G, Tjønna AE, Najjar SM, Nilsen OG, Catalucci D, Grimaldi S, Contu R, Steinshamn S, Condorelli G, Smith GL, Ellingsen O, Waldum H, Wisløff U
Inhalation toxicology 2008 May;20(7):635-46
Inhalation toxicology 2008 May;20(7):635-46
Positive inotropic effects of epigallocatechin-3-gallate (EGCG) involve activation of Na+/H+ and Na+/Ca2+ exchangers.
Lorenz M, Hellige N, Rieder P, Kinkel HT, Trimpert C, Staudt A, Felix SB, Baumann G, Stangl K, Stangl V
European journal of heart failure 2008 May;10(5):439-45
European journal of heart failure 2008 May;10(5):439-45
Neuronal nitric oxide synthase signaling within cardiac myocytes targets phospholamban.
Wang H, Kohr MJ, Traynham CJ, Wheeler DG, Janssen PM, Ziolo MT
American journal of physiology. Cell physiology 2008 Jun;294(6):C1566-75
American journal of physiology. Cell physiology 2008 Jun;294(6):C1566-75
Cardiomyocyte overexpression of neuronal nitric oxide synthase delays transition toward heart failure in response to pressure overload by preserving calcium cycling.
Loyer X, Gómez AM, Milliez P, Fernandez-Velasco M, Vangheluwe P, Vinet L, Charue D, Vaudin E, Zhang W, Sainte-Marie Y, Robidel E, Marty I, Mayer B, Jaisser F, Mercadier JJ, Richard S, Shah AM, Bénitah JP, Samuel JL, Heymes C
Circulation 2008 Jun 24;117(25):3187-98
Circulation 2008 Jun 24;117(25):3187-98
Exercise training delays cardiac dysfunction and prevents calcium handling abnormalities in sympathetic hyperactivity-induced heart failure mice.
Medeiros A, Rolim NP, Oliveira RS, Rosa KT, Mattos KC, Casarini DE, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC
Journal of applied physiology (Bethesda, Md. : 1985) 2008 Jan;104(1):103-9
Journal of applied physiology (Bethesda, Md. : 1985) 2008 Jan;104(1):103-9
PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility.
Cha H, Kim JM, Oh JG, Jeong MH, Park CS, Park J, Jeong HJ, Park BK, Lee YH, Jeong D, Yang DK, Bernecker OY, Kim do H, Hajjar RJ, Park WJ
Journal of molecular and cellular cardiology 2008 Dec;45(6):796-803
Journal of molecular and cellular cardiology 2008 Dec;45(6):796-803
Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure.
Bartholomeu JB, Vanzelli AS, Rolim NP, Ferreira JC, Bechara LR, Tanaka LY, Rosa KT, Alves MM, Medeiros A, Mattos KC, Coelho MA, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Ramires PR, Guatimosim S, Brum PC
Journal of molecular and cellular cardiology 2008 Aug;45(2):240-9
Journal of molecular and cellular cardiology 2008 Aug;45(2):240-9
Inhibition of protein phosphatase 1 by inhibitor-2 exacerbates progression of cardiac failure in a model with pressure overload.
Grote-Wessels S, Baba HA, Boknik P, El-Armouche A, Fabritz L, Gillmann HJ, Kucerova D, Matus M, Müller FU, Neumann J, Schmitz M, Stümpel F, Theilmeier G, Wohlschlaeger J, Schmitz W, Kirchhefer U
Cardiovascular research 2008 Aug 1;79(3):464-71
Cardiovascular research 2008 Aug 1;79(3):464-71
Proteomic studies of PP2A-B56gamma1 phosphatase complexes reveal phosphorylation-regulated partners in cardiac local signaling.
Zhou XW, Mudannayake M, Green M, Gigena MS, Wang G, Shen RF, Rogers TB
Journal of proteome research 2007 Sep;6(9):3433-42
Journal of proteome research 2007 Sep;6(9):3433-42
Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban.
Kemi OJ, Ellingsen O, Ceci M, Grimaldi S, Smith GL, Condorelli G, Wisløff U
Journal of molecular and cellular cardiology 2007 Sep;43(3):354-61
Journal of molecular and cellular cardiology 2007 Sep;43(3):354-61
Local actions of atrial natriuretic peptide counteract angiotensin II stimulated cardiac remodeling.
Kilić A, Bubikat A, Gassner B, Baba HA, Kuhn M
Endocrinology 2007 Sep;148(9):4162-9
Endocrinology 2007 Sep;148(9):4162-9
Serotonin increases L-type Ca2+ current and SR Ca2+ content through 5-HT4 receptors in failing rat ventricular cardiomyocytes.
Birkeland JA, Swift F, Tovsrud N, Enger U, Lunde PK, Qvigstad E, Levy FO, Sejersted OM, Sjaastad I
American journal of physiology. Heart and circulatory physiology 2007 Oct;293(4):H2367-76
American journal of physiology. Heart and circulatory physiology 2007 Oct;293(4):H2367-76
Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload.
Quaile MP, Rossman EI, Berretta RM, Bratinov G, Kubo H, Houser SR, Margulies KB
Journal of molecular and cellular cardiology 2007 Nov;43(5):552-63
Journal of molecular and cellular cardiology 2007 Nov;43(5):552-63
Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.
MacDonnell SM, Kubo H, Harris DM, Chen X, Berretta R, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR
American journal of physiology. Heart and circulatory physiology 2007 Nov;293(5):H3122-9
American journal of physiology. Heart and circulatory physiology 2007 Nov;293(5):H3122-9
Myocardial protection by isoflurane preconditioning preserves Ca2+ cycling proteins independent of sarcolemmal and mitochondrial KATP channels.
An J, Bosnjak ZJ, Jiang MT
Anesthesia and analgesia 2007 Nov;105(5):1207-13, table of contents
Anesthesia and analgesia 2007 Nov;105(5):1207-13, table of contents
Exercise training improves the net balance of cardiac Ca2+ handling protein expression in heart failure.
Rolim NP, Medeiros A, Rosa KT, Mattos KC, Irigoyen MC, Krieger EM, Krieger JE, Negrão CE, Brum PC
Physiological genomics 2007 May 11;29(3):246-52
Physiological genomics 2007 May 11;29(3):246-52
Reduced contractile response to alpha1-adrenergic stimulation in atria from mice with chronic cardiac calmodulin kinase II inhibition.
Grimm M, El-Armouche A, Zhang R, Anderson ME, Eschenhagen T
Journal of molecular and cellular cardiology 2007 Mar;42(3):643-52
Journal of molecular and cellular cardiology 2007 Mar;42(3):643-52
Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII.
Huke S, Bers DM
Journal of molecular and cellular cardiology 2007 Mar;42(3):590-9
Journal of molecular and cellular cardiology 2007 Mar;42(3):590-9
CaMKII inhibition protects against necrosis and apoptosis in irreversible ischemia-reperfusion injury.
Vila-Petroff M, Salas MA, Said M, Valverde CA, Sapia L, Portiansky E, Hajjar RJ, Kranias EG, Mundiña-Weilenmann C, Mattiazzi A
Cardiovascular research 2007 Mar 1;73(4):689-98
Cardiovascular research 2007 Mar 1;73(4):689-98
Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload.
Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H620-7
American journal of physiology. Heart and circulatory physiology 2007 Jul;293(1):H620-7
Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes.
Yang D, Zhu WZ, Xiao B, Brochet DX, Chen SR, Lakatta EG, Xiao RP, Cheng H
Circulation research 2007 Feb 16;100(3):399-407
Circulation research 2007 Feb 16;100(3):399-407
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Mørk HK, Sjaastad I, Sande JB, Periasamy M, Sejersted OM, Louch WE
Journal of molecular and cellular cardiology 2007 Aug;43(2):177-86
Journal of molecular and cellular cardiology 2007 Aug;43(2):177-86
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Ruan H, Mitchell S, Vainoriene M, Lou Q, Xie LH, Ren S, Goldhaber JI, Wang Y
Circulation 2007 Aug 7;116(6):596-605
Circulation 2007 Aug 7;116(6):596-605
Activation of CaMKIIdeltaC is a common intermediate of diverse death stimuli-induced heart muscle cell apoptosis.
Zhu W, Woo AY, Yang D, Cheng H, Crow MT, Xiao RP
The Journal of biological chemistry 2007 Apr 6;282(14):10833-9
The Journal of biological chemistry 2007 Apr 6;282(14):10833-9
Regulatory role of ovarian sex hormones in calcium uptake activity of cardiac sarcoplasmic reticulum.
Bupha-Intr T, Wattanapermpool J
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1101-8
American journal of physiology. Heart and circulatory physiology 2006 Sep;291(3):H1101-8
Alterations in cardiac contractile performance and sarcoplasmic reticulum function in sucrose-fed rats is associated with insulin resistance.
Vasanji Z, Cantor EJ, Juric D, Moyen M, Netticadan T
American journal of physiology. Cell physiology 2006 Oct;291(4):C772-80
American journal of physiology. Cell physiology 2006 Oct;291(4):C772-80
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Li B, Kaetzel MA, Dedman JR
Biochemical and biophysical research communications 2006 Nov 10;350(1):179-84
Biochemical and biophysical research communications 2006 Nov 10;350(1):179-84
Phospholamban phosphorylation sites enhance the recovery of intracellular Ca2+ after perfusion arrest in isolated, perfused mouse heart.
Valverde CA, Mundiña-Weilenmann C, Reyes M, Kranias EG, Escobar AL, Mattiazzi A
Cardiovascular research 2006 May 1;70(2):335-45
Cardiovascular research 2006 May 1;70(2):335-45
Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy.
Yamada M, Ikeda Y, Yano M, Yoshimura K, Nishino S, Aoyama H, Wang L, Aoki H, Matsuzaki M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jun;20(8):1197-9
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Jun;20(8):1197-9
L-arginine administration recovers sarcoplasmic reticulum function in ischemic reperfused hearts by preventing calpain activation.
Chohan PK, Singh RB, Dhalla NS, Netticadan T
Cardiovascular research 2006 Jan;69(1):152-63
Cardiovascular research 2006 Jan;69(1):152-63
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Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 17;103(3):511-8
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 17;103(3):511-8
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Kirchhefer U, Hanske G, Jones LR, Justus I, Kaestner L, Lipp P, Schmitz W, Neumann J
Cell calcium 2006 Feb;39(2):131-42
Cell calcium 2006 Feb;39(2):131-42
Alveolar hypoxia induces left ventricular diastolic dysfunction and reduces phosphorylation of phospholamban in mice.
Larsen KO, Sjaastad I, Svindland A, Krobert KA, Skjønsberg OH, Christensen G
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H507-16
American journal of physiology. Heart and circulatory physiology 2006 Aug;291(2):H507-16
Enhanced activity of the myocardial Na+/H+ exchanger NHE-1 contributes to cardiac remodeling in atrial natriuretic peptide receptor-deficient mice.
Kilic A, Velic A, De Windt LJ, Fabritz L, Voss M, Mitko D, Zwiener M, Baba HA, van Eickels M, Schlatter E, Kuhn M
Circulation 2005 Oct 11;112(15):2307-17
Circulation 2005 Oct 11;112(15):2307-17
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Kirchhefer U, Baba HA, Bokník P, Breeden KM, Mavila N, Brüchert N, Justus I, Matus M, Schmitz W, Depaoli-Roach AA, Neumann J
Cardiovascular research 2005 Oct 1;68(1):98-108
Cardiovascular research 2005 Oct 1;68(1):98-108
Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia.
Urboniene D, Dias FA, Peña JR, Walker LA, Solaro RJ, Wolska BM
Circulation research 2005 Jul 8;97(1):70-7
Circulation research 2005 Jul 8;97(1):70-7
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle.
Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR Jr, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J Jr, Chen J, Xiao RP, Cheng H, Fu XD
Cell 2005 Jan 14;120(1):59-72
Cell 2005 Jan 14;120(1):59-72
Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure.
Mishra S, Sabbah HN, Rastogi S, Imai M, Gupta RC
Heart and vessels 2005 Feb;20(1):23-32
Heart and vessels 2005 Feb;20(1):23-32
Frequency-dependent acceleration of relaxation in mammalian heart: a property not relying on phospholamban and SERCA2a phosphorylation.
Valverde CA, Mundiña-Weilenmann C, Said M, Ferrero P, Vittone L, Salas M, Palomeque J, Petroff MV, Mattiazzi A
The Journal of physiology 2005 Feb 1;562(Pt 3):801-13
The Journal of physiology 2005 Feb 1;562(Pt 3):801-13
Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure.
Ai X, Curran JW, Shannon TR, Bers DM, Pogwizd SM
Circulation research 2005 Dec 9;97(12):1314-22
Circulation research 2005 Dec 9;97(12):1314-22
Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats.
Wold LE, Dutta K, Mason MM, Ren J, Cala SE, Schwanke ML, Davidoff AJ
Journal of molecular and cellular cardiology 2005 Aug;39(2):297-307
Journal of molecular and cellular cardiology 2005 Aug;39(2):297-307
Daily administration of interleukin-18 causes myocardial dysfunction in healthy mice.
Woldbaek PR, Sande JB, Strømme TA, Lunde PK, Djurovic S, Lyberg T, Christensen G, Tønnessen T
American journal of physiology. Heart and circulatory physiology 2005 Aug;289(2):H708-14
American journal of physiology. Heart and circulatory physiology 2005 Aug;289(2):H708-14
Role of phosphorylation of Thr(17) residue of phospholamban in mechanical recovery during hypercapnic acidosis.
Mundiña-Weilenmann C, Ferrero P, Said M, Vittone L, Kranias EG, Mattiazzi A
Cardiovascular research 2005 Apr 1;66(1):114-22
Cardiovascular research 2005 Apr 1;66(1):114-22
Coordinate downregulation of CaM kinase II and phospholamban accompanies contractile phenotype transition in the hyperthyroid rabbit soleus.
Jiang M, Xu A, Jones DL, Narayanan N
American journal of physiology. Cell physiology 2004 Sep;287(3):C622-32
American journal of physiology. Cell physiology 2004 Sep;287(3):C622-32
Cardiac contractile dysfunction in J2N-k cardiomyopathic hamsters is associated with impaired SR function and regulation.
Babick AP, Cantor EJ, Babick JT, Takeda N, Dhalla NS, Netticadan T
American journal of physiology. Cell physiology 2004 Nov;287(5):C1202-8
American journal of physiology. Cell physiology 2004 Nov;287(5):C1202-8
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.
Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T
The Journal of biological chemistry 2004 May 14;279(20):21383-93
The Journal of biological chemistry 2004 May 14;279(20):21383-93
The sarcoplasmic reticulum proteins are targets for calpain action in the ischemic-reperfused heart.
Singh RB, Chohan PK, Dhalla NS, Netticadan T
Journal of molecular and cellular cardiology 2004 Jul;37(1):101-10
Journal of molecular and cellular cardiology 2004 Jul;37(1):101-10
Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility.
Zhao W, Uehara Y, Chu G, Song Q, Qian J, Young K, Kranias EG
Journal of molecular and cellular cardiology 2004 Aug;37(2):607-12
Journal of molecular and cellular cardiology 2004 Aug;37(2):607-12
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Supportive validation
- Submitted by
- Badrilla Ltd (provider)
- Main image
- Experimental details
- Western blot
- Sample type
- Canine sarcoplasmic reticulum +/- PKA treatment and rat cardiac myocytes +/- isoprenaline treatment (not boiled)
- Validation comment
- Ab stains for PLB in CaMKII treated samples, but not PKA or unphosphorylated. Staining is completely blocked by the addition of peptide
- Primary Ab dilution
- 3.513888889
- Secondary Ab dilution
- 1.430555556
- Protocol
- Protocol
