A010-13

antibody from Badrilla Ltd
Targeting: PLN CMD1P, PLB
Provider product page for A010-13
Western blot
Immunohistochemistry

Antibody data

Product number
A010-13 - Provider product page
Provider
Badrilla Ltd
Proper citation
Badrilla Cat#A010-13, RRID:AB_2617048
Product name
Phospholamban Phospho Threonine-17 Anti-Serum
Antibody type
Polyclonal
Antigen
Synthetic peptide
Description
Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca2+/CaM-dependent (Thr-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure
Host
Rabbit
Antigen sequence
R9SAIRRAST(PO3H2)IEY20 conjugated t
o KLH.
Isotype
IgG
Vial size
20 µl
Storage
Lyophilised: 4 °C Reconstituted:-80 °C
Handling
Reconstitute lyophilised powder in 20 µl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles
PLN protein structure - A010-13 shown in red.