606701

antibody from BioLegend

Targeting: EIF2A EIF-2A

Western blot (Data presented on provider website)

Antibody Data

Product number

606701

Provider

BioLegend

Proper citation

BioLegend Cat#606701, RRID:AB_315682

Product name

Purified anti-eIF2‡

Antibody type

Polyclonal

Antigen

Recombinant (partial), C-terminal

Description

eIF2α (also known as eukaryotic translation initiation factor 2, subunit 1 alpha) is a 35 kD member of the eukaryotic translation initiation factor 2 family. This cytoplasmic protein is ubiquitously expressed and can downregulate protein synthesis when phosphorylated by PKR kinase under stress conditions (hypoxia, viral infection, ER stress). Increased expression of eIF2α has been linked to progression of thyroid carcinoma.Signaling inhibited by p58 (IPK) and PKR phosphorylation. Can attenuate the unfolded protein response and inhibits translation. This protein has been shown to interact with eIF2B α, eIF2B δ, eIF2B β subunit 2, p67, p68, and PKR. eIF2α is a target for cleavage by caspase 3, caspase 6, caspase 8, and caspase 10. The Poly6067 antibody recognizes both mouse and human eIF2α and has been shown to be useful for Western blotting.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Vial size

50 µl

Storage

Upon receipt, store frozen at -20° C.