FNab04272

antibody from FineTest Biotech
Targeting: IL33 C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV
Provider product page for FNab04272
Western blot
ELISA
Immunohistochemistry

Antibody data

Product number
FNab04272 - Provider product page
Provider
FineTest Biotech
Product name
IL33 antibody
Antibody type
Monoclonal
Antigen
Recombinant protein fragment
Description
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells(PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury(PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets(PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation(PubMed:18787100).
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
interleukin 33
Epitope
IgG1
Isotype
IgG
Antibody clone number
400000000
Vial size
100¦Ìg
Concentration
Protein A+G purification
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
IL33 protein structure - FNab04272 shown in red.