Ab006917

Targeting: IL33 C9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV

Western blot

Immunohistochemistry

Antibody data

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Validation data

Product number: Ab006917 - Provider product page
Provider: Aladdin Scientific Corporation
Product name: IL-33 Mouse mAb
Antibody type: Monoclonal
Description: Mouse anti Human IL-33 Antibody, Monoclonal antibody (C11), could be used for WB, IHC and so on.Application WB: 0.01-3µg/mLIHC: 5-30µg/mLProtein FunctionCytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.
Reactivity: Human, Rat
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: AA 112-270
Antibody clone number: C11
Vial size: 10μl,20μl
Concentration: Lot by Lot
Storage: Store at 4℃ short term (1-2 weeks). Store at -20℃ long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

IL33 protein structure - Ab006917 shown in red.