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Learn20566-1-AP
antibody from Proteintech Group
Targeting: DDX58
DKFZp434J1111, FLJ13599, RIG-1, RIG-I, RIG1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 20566-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20566-1-AP, RRID:AB_10700006
- Product name
- RIG-1/DDX58 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RIG-1/DDX58 antibody (Cat. #20566-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Negatively Regulates Innate Immunity Against RNA Virus by Targeting RIG-I in Macrophages.
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
STING1 is essential for an RNA-virus triggered autophagy.
The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo.
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes.
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism.
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Zou Z, Li M, Zhou Y, Li J, Pan T, Lai L, Wang Q, Zhang L, Wang Q, Song Y, Zhang Y
Frontiers in immunology 2021;12:642715
Frontiers in immunology 2021;12:642715
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Li N, Hui H, Bray B, Gonzalez GM, Zeller M, Anderson KG, Knight R, Smith D, Wang Y, Carlin AF, Rana TM
Cell reports 2021 May 11;35(6):109091
Cell reports 2021 May 11;35(6):109091
Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.
Shen Y, Tang K, Chen D, Hong M, Sun F, Wang S, Ke Y, Wu T, Sun R, Qian J, Du Y
Cell reports 2021 Jun 22;35(12):109272
Cell reports 2021 Jun 22;35(12):109272
IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.
Jiang Z, Wei F, Zhang Y, Wang T, Gao W, Yu S, Sun H, Pu J, Sun Y, Wang M, Tong Q, Gao C, Chang KC, Liu J
Nature microbiology 2021 Jul;6(7):932-945
Nature microbiology 2021 Jul;6(7):932-945
STING1 is essential for an RNA-virus triggered autophagy.
Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y
Autophagy 2021 Aug 2;:1-13
Autophagy 2021 Aug 2;:1-13
The natural compound Cirsitakaoside enhances antiviral innate responses against vesicular stomatitis virus in vitro and in vivo.
Di Q, Zhu H, Pu D, Zhao X, Li X, Ma X, Xiao W, Chen W
International immunopharmacology 2020 Sep;86:106783
International immunopharmacology 2020 Sep;86:106783
Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2.
Wang C, Li Y, Yan S, Wang H, Shao X, Xiao M, Yang B, Qin G, Kong R, Chen R, Zhang N
Nature communications 2020 Jun 22;11(1):3162
Nature communications 2020 Jun 22;11(1):3162
Butyrate Reprograms Expression of Specific Interferon-Stimulated Genes.
Chemudupati M, Kenney AD, Smith AC, Fillinger RJ, Zhang L, Zani A, Liu SL, Anderson MZ, Sharma A, Yount JS
Journal of virology 2020 Jul 30;94(16)
Journal of virology 2020 Jul 30;94(16)
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Zhou Z, Ni J, Li J, Huo C, Miao N, Yin F, Cheng Q, Xu D, Xie H, Chen P, Zheng P, Zhang Y, Zhou L, Zhang W, Yu C, Liu J, Lu L
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
FTSJ3 is an RNA 2'-O-methyltransferase recruited by HIV to avoid innate immune sensing.
Ringeard M, Marchand V, Decroly E, Motorin Y, Bennasser Y
Nature 2019 Jan;565(7740):500-504
Nature 2019 Jan;565(7740):500-504
Ribosome biogenesis restricts innate immune responses to virus infection and DNA.
Bianco C, Mohr I
eLife 2019 Dec 16;8
eLife 2019 Dec 16;8
Influenza Virus NS1 Protein-RNA Interactome Reveals Intron Targeting.
Zhang L, Wang J, Muñoz-Moreno R, Kim M, Sakthivel R, Mo W, Shao D, Anantharaman A, García-Sastre A, Conrad NK, Fontoura BMA
Journal of virology 2018 Dec 15;92(24)
Journal of virology 2018 Dec 15;92(24)
Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.
Burgess HM, Mohr I
Journal of virology 2018 Aug 1;92(15)
Journal of virology 2018 Aug 1;92(15)
Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus.
Zhang LK, Xin QL, Zhu SL, Wan WW, Wang W, Xiao G
Journal of virology 2016 Nov 15;90(22):10259-10270
Journal of virology 2016 Nov 15;90(22):10259-10270
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D
Scientific reports 2016 Jun 8;6:27597
Scientific reports 2016 Jun 8;6:27597
The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism.
Wang Y, Liu L
mBio 2016 Feb 9;7(1):e01872-15
mBio 2016 Feb 9;7(1):e01872-15
Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins.
Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P
The Journal of general virology 2015 Jan;96(Pt 1):170-182
The Journal of general virology 2015 Jan;96(Pt 1):170-182
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 20566-1-AP(DDX58 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using DDX58 antibody 20566-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
